Insecticide and Antimalarial Resistance Markers
A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Vector-Borne Diseases".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 4945
Special Issue Editor
2. Department of Biochemistry, Bayero University, Kano PMB 3011, Nigeria
3. Centre for Research in Infectious Diseases (CRID), Yaoundé P.O. Box 13591, Cameroon
Interests: mosquito; vectors; Anopheles; malaria; insecticides; resistance; Plasmodium; antimalarial; genes; functional genomics; transcriptomics; transgenesis; agricultural pests; pesticides
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Malaria is one of the major diseases affecting millions of people around the world, with ~400,000 deaths globally—more than 90% of these in sub-Saharan Africa.
Malaria control relies heavily on a two-pronged approach: the combination of malaria vector control and chemotherapy against Plasmodium. However, the escalation in insecticide resistance in the malaria vectors and widespread antimalarial resistance in the Plasmodium which is reported across the world is threatening to derail malaria control, with the progress stalling in recent years. Populations of mosquitoes have become highly resistant to the ingredients (especially the pyrethroids which are the most widely used chemicals) in use for the impregnation of long-lasting insecticidal nets (LLINs) and indoor residual spraying. The failure of antimalarials has become disproportionately high, including cases of artemisinin resistance, the component of front-line treatment, the ACTs. Resistance is also confounded by the high heterogeneity in its molecular basis—for example, ACT resistance across Africa despite the absence of the major mutations in the kelch13 gene validated/known to drive/delay parasite clearance. The detection and validation of metabolic and target-site insensitivity resistance markers aid the early detection of resistance alleles, allow tracking of their evolution in the field, and facilitate evidence-based control and resistance-management strategies by stakeholders and National Malaria Control Programs. This Special Issue will showcase research efforts to detect and validate known insecticides and/or antimalarial resistance markers, as well as discovery and validation of novel markers of resistance. Suitable manuscripts will preferably cover: the distribution and resistance profiles of the major malaria vectors across different regions of the world; the distribution and resistance profiles of the various genotypes of Plasmodium across different regions of the world; insecticide resistance surveillance; antimalarial resistance surveillance; known and novel insecticide resistance markers; known and novel antimalarial resistance markers; genetic diversity and spread of resistance markers; and the operational impact of resistance markers on malaria control.
Dr. Sulaiman S Ibrahim
Guest Editor
Manuscript Submission Information
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Keywords
- Malaria
- Anopheles
- Plasmodium
- Resistance
- Markers
- Control
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