Biotechnologies Applied in Vaccine Research

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccine Adjuvants".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 7312

Special Issue Editor


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Guest Editor
Department of Nursing and Department of Medical Technology, Jenteh Junior College of Medicine, Nursing and Management, Miaoli County 35664, Taiwan
Interests: biopharmaceuticals; vaccine; biotechnology; nanotechnology; microbiology; bacteriology; virology
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Special Issue Information

Dear Colleagues,

Traditional vaccines can be classified as inactivated vaccines, live attenuated vaccines, and subunit vaccines given orally, via intramuscular (IM) injection, and via subcutaneous (SC) injection. Recently, recombinant protein vaccines, DNA vaccines, mRNA vaccines, and multiple/alternative administration route vaccines have been developed for human use to make vaccines more secure and effective. These vaccine platforms have been developed using various biotechnologies, such as adenovirus vectors, nanoparticles, mRNA, recombination DNA, and other vaccine delivery systems.

In this Special Issue, we are inviting contributions related to advances in biotechnologies applied in vaccine research. It will explore the biotechnologies applied in the development of vaccine research and platforms. We welcome original research articles and reviews. Research areas may include vaccines, biotechnology, vaccine vectors, DNA, mRNA, subunits, novel adjuvants, and delivery systems. We look forward to receiving your contributions.

Dr. Yuan-Chuan Chen
Guest Editor

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Keywords

  • vaccine
  • biotechnology
  • vector
  • nanoparticle
  • virus
  • bacteria
  • recombination DNA
  • mRNA
  • subunit
  • adjuvant
  • delivery

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Published Papers (2 papers)

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Review

20 pages, 4599 KiB  
Review
Recent Advances in Lipid Nanoparticles and Their Safety Concerns for mRNA Delivery
by Jialiang Wang, Yaopeng Ding, Kellie Chong, Meng Cui, Zeyu Cao, Chenjue Tang, Zhen Tian, Yuping Hu, Yu Zhao and Shaoyi Jiang
Vaccines 2024, 12(10), 1148; https://doi.org/10.3390/vaccines12101148 - 8 Oct 2024
Cited by 1 | Viewed by 4613
Abstract
Introduction: The advent of lipid nanoparticles (LNPs) as a delivery platform for mRNA therapeutics has revolutionized the biomedical field, particularly in treating infectious diseases, cancer, genetic disorders, and metabolic diseases. Recent Advances in Therapeutic LNPs: LNPs, composed of ionizable lipids, phospholipids, cholesterol, and [...] Read more.
Introduction: The advent of lipid nanoparticles (LNPs) as a delivery platform for mRNA therapeutics has revolutionized the biomedical field, particularly in treating infectious diseases, cancer, genetic disorders, and metabolic diseases. Recent Advances in Therapeutic LNPs: LNPs, composed of ionizable lipids, phospholipids, cholesterol, and polyethylene glycol (PEG) lipids, facilitate efficient cellular uptake and cytosolic release of mRNA while mitigating degradation by nucleases. However, as synthetic entities, LNPs face challenges that alter their therapeutic efficacy and safety concerns. Toxicity/Reactogenicity/Immunogenicity: This review provides a comprehensive overview of the latest advancements in LNP research, focusing on preclinical safety assessments encompassing toxicity, reactogenicity, and immunogenicity. Summary and Outlook: Additionally, it outlines potential strategies for addressing these challenges and offers insights into future research directions for enhancing the application of LNPs in mRNA therapeutics. Full article
(This article belongs to the Special Issue Biotechnologies Applied in Vaccine Research)
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21 pages, 975 KiB  
Review
Novel Administration Routes, Delivery Vectors, and Application of Vaccines Based on Biotechnologies: A Review
by Chung-I Rai, Tsu-Hsiang Kuo and Yuan-Chuan Chen
Vaccines 2024, 12(9), 1002; https://doi.org/10.3390/vaccines12091002 - 1 Sep 2024
Cited by 1 | Viewed by 2121
Abstract
Traditional vaccines can be classified into inactivated vaccines, live attenuated vaccines, and subunit vaccines given orally or via intramuscular (IM) injection or subcutaneous (SC) injection for the prevention of infectious diseases. Recently, recombinant protein vaccines, DNA vaccines, mRNA vaccines, and multiple/alternative administering route [...] Read more.
Traditional vaccines can be classified into inactivated vaccines, live attenuated vaccines, and subunit vaccines given orally or via intramuscular (IM) injection or subcutaneous (SC) injection for the prevention of infectious diseases. Recently, recombinant protein vaccines, DNA vaccines, mRNA vaccines, and multiple/alternative administering route vaccines (e.g., microneedle or inhalation) have been developed to make vaccines more secure, effective, tolerable, and universal for the public. In addition to preventing infectious diseases, novel vaccines have currently been developed or are being developed to prevent or cure noninfectious diseases, including cancer. These vaccine platforms have been developed using various biotechnologies such as viral vectors, nanoparticles, mRNA, recombination DNA, subunit, novel adjuvants, and other vaccine delivery systems. In this review, we will explore the development of novel vaccines applying biotechnologies, such as vaccines based on novel administration routes, vaccines based on novel vectors, including viruses and nanoparticles, vaccines applied for cancer prevention, and therapeutic vaccines. Full article
(This article belongs to the Special Issue Biotechnologies Applied in Vaccine Research)
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