Innovations in Vaccine Technology

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Attenuated/Inactivated/Live and Vectored Vaccines".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1574

Special Issue Editor


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Guest Editor
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia
Interests: peptides; subunit vaccines; vaccine development; infectious diseases
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Special Issue Information

Dear Colleagues,

Advances in vaccine technology have improved our ability to prevent infectious diseases,  revolutionizing global public health. Scientists have pursued safe and more effective immunization strategies from traditional approaches such as attenuated or inactivated vaccines to modern techniques such as mRNA and viral vector vaccines. These innovations have increased our capacity to respond to emerging threats such as pandemics. In addition, innovations in vaccine delivery systems, adjuvants and formulation techniques have further improved vaccine efficacy, safety and accessibility. Moreover, the integration of computational modeling, artificial intelligence and bioinformatics has made it easier to design and optimize novel vaccine candidates.

This Special Issue focuses on groundbreaking research and discoveries in the field of vaccine technology. We are inviting researchers, clinicians and stakeholders to contribute their insights and findings that drive forward the frontier of immunization and improve health.

Dr. Rachel Stephenson
Guest Editor

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Keywords

  • inactivated vaccines
  • live-attenuated vaccines
  • messenger RNA (mRNA) vaccines
  • subunit, recombinant, polysaccharide and conjugate vaccines
  • toxoid vaccines
  • viral vector vaccines
  • personalized vaccines
  • antigen design
  • reverse vaccinology
  • lipid nanoparticles
  • cell-based vaccine production
  • virus-like particles

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Published Papers (1 paper)

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Research

13 pages, 1403 KiB  
Article
Analytical Performance of a Multiplexed Microarray Assay for Rapid Identification and Quantification of a Multivalent mRNA Vaccine
by Megan N. Gerold, Evan Toth, Rebecca H. Blair, Rachel Y. Gao, Durgesh V. Nadkarni, Sutapa Barua, Joshua Woods, Kathy L. Rowlen and Erica D. Dawson
Vaccines 2024, 12(10), 1144; https://doi.org/10.3390/vaccines12101144 - 5 Oct 2024
Viewed by 1074
Abstract
mRNA vaccines were highly effective in response to the COVID-19 pandemic, making them an attractive platform to address cancers and other infectious diseases. Many new mRNA vaccines in development are multivalent, which represents a difficulty for the standard assays commonly used to characterize [...] Read more.
mRNA vaccines were highly effective in response to the COVID-19 pandemic, making them an attractive platform to address cancers and other infectious diseases. Many new mRNA vaccines in development are multivalent, which represents a difficulty for the standard assays commonly used to characterize the critical quality attributes of monovalent formulations. Here, we present a multiplexed analytical tool with nucleic acid microarray technology using the VaxArray platform that measures the identity and quantity of mono- and multivalent mixtures of naked mRNA and mRNA encapsulated in lipid nanoparticle formulations in under 2 h without any additional preparation steps, such as extraction or RT-PCR. Using a quadrivalent mixture of encapsulated mRNA constructs that encode for four unique proteins in a vaccine formulation, the VaxArray mRNA assay was demonstrated to be highly specific for each mRNA with sensitivity < 1 µg/mL. The quantification of individual mRNAs within the lipid nanoparticle mixture resulted in a precision of ≤10% RSD and an accuracy of 100 ± 9%. Full article
(This article belongs to the Special Issue Innovations in Vaccine Technology)
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