Lung Immunity to Viral Infections
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: 20 April 2025 | Viewed by 109
Special Issue Editor
Interests: respiratory virus; innate immune response; antiviral response; adaptative immune response; host-pathogen interaction; microbiota
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lung immunity to viral infections involves a complex interaction between the immune system and the mucosal epithelia. To develop new immunotherapies or vaccines to protect against respiratory viral infections, a deeper understanding of host–pathogen interactions in the lungs is essential.
The first line of defense against viral infection includes mucus and cilia, which trap and expel viruses. This is followed by the activation of cellular components of the innate immune system, such as macrophages and dendritic cells. Various phenotypes of these cells coordinate the initial immune response by secreting cytokines and chemokines that induce inflammation. The production of interferons is also crucial in triggering an antiviral response. At this point, precise immune regulation is necessary to prevent lung tissue damage from excessive inflammation.
The adaptive immune response further orchestrates the overall immune defense, with T and B cells playing critical roles in clearing viruses and providing protection against future infections. However, respiratory viruses can evade immune detection by altering their surface proteins or impairing antiviral responses.
Understanding lung immunity to viral infections underscores the importance of maintaining overall respiratory health and highlights the impact of factors such as microbiota, smoking, and pollution on immune function against viruses. For this Special Issue, we welcome original research papers, communications, and review articles that contribute to an improved understanding of these interactions in the lungs during the immune response against viral infection.
Dr. Ana Paula Duarte De Souza
Guest Editor
Manuscript Submission Information
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Keywords
- respiratory virus
- lung immune response
- vaccines to respiratory virus
- microbiota and lung immune response
- environmental factors and lung immune responses
- virus–host interaction in the lung
- immunotherapies to prevent or treat respiratory viral infection
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