Complementary Strategies in Drug Delivery: From Particle Engineering to System Optimization

Topic Information

Dear Colleagues,

This theme aims to explore the diverse world of drug delivery systems, emphasising the integration of various techniques and approaches to enhance drug efficacy, stability, and patient compliance. It will cover a range of topics, including but not limited to, the following:

• Advancements in Spray Drying: Focusing on novel techniques using two- and multiple-fluid spray drying to improve drug solubility and bioavailability, particularly for poorly soluble drugs;
• Innovations in Inhalation Drug Delivery: Highlighting the latest developments in pulmonary drug delivery systems, with a special focus on patient compliance and the role of particle engineering in enhancing drug efficacy;
• Crystal Engineering in Pharmaceuticals: Discussing the impact of crystal engineering on drug properties, such as solubility, stability, and bioavailability, and its role in overcoming formulation challenges;
• Emerging Trends in Oral Drug Delivery: Exploring new technologies and approaches in oral drug delivery, including targeted delivery systems and strategies to overcome biological barriers for improved drug absorption;
• Cross-Disciplinary Approaches: Encouraging submissions that demonstrate the intersection of these areas, such as the use of crystal engineering in inhalation drug delivery or the application of two- and three-fluid spray drying techniques in oral drug formulations.

Prof. Dr. Barbara R. Conway
Dr. Hisham Al-Obaidi
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Bioengineering bioengineering	3.8	4.0	2014	15.6 Days	CHF 2700	Submit
Molecules molecules	4.2	7.4	1996	15.1 Days	CHF 2700	Submit
Pharmaceuticals pharmaceuticals	4.3	6.1	2004	12.8 Days	CHF 2900	Submit
Pharmaceutics pharmaceutics	4.9	7.9	2009	14.9 Days	CHF 2900	Submit
Processes processes	2.8	5.1	2013	14.4 Days	CHF 2400	Submit
Scientia Pharmaceutica scipharm	2.3	4.6	1930	31.4 Days	CHF 1000	Submit

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Published Papers (2 papers)

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Journals

All Bioengineering Molecules Pharmaceuticals Pharmaceutics Processes Sci. Pharm.

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25 pages, 4244 KiB  

Open AccessArticle

Back to Nature: Development and Optimization of Bioinspired Nanocarriers for Potential Breast Cancer Treatment

by Sally Safwat, Rania M. Hathout, Rania A. H. Ishak and Nahed D. Mortada

Sci. Pharm. 2024, 92(3), 50; https://doi.org/10.3390/scipharm92030050 - 2 Sep 2024

Viewed by 1258

Abstract

This study focuses on the preparation and optimization of caffeic acid (CA)-loaded casein nanoparticles (CS NPs) via the Box–Behnken design (BBD) for potential applications in cancer treatment. CS NPs were loaded with CA as a promising anti-cancer molecule. Non-hazardous green materials were exploited [...] Read more.

This study focuses on the preparation and optimization of caffeic acid (CA)-loaded casein nanoparticles (CS NPs) via the Box–Behnken design (BBD) for potential applications in cancer treatment. CS NPs were loaded with CA as a promising anti-cancer molecule. Non-hazardous green materials were exploited for nanoparticle fabrication. The BBD was used, followed by a desirability function to select the optimum formulation. The BBD was adopted as it avoids the runs implemented in extreme conditions, hence making it suitable for proteins. CS NPs were characterized regarding particle size (PS), size distribution (PDI), zeta potential (ZP), drug entrapment, morphology using TEM, differential scanning calorimetry, molecular docking, in vitro release, and cytotoxicity studies. PS, PDI, and ZP had significant responses, while EE% was insignificant. The suggested models were quadratic with high fitting. Optimized NPs showed PS = 110.31 ± 1.02 nm, PDI = 0.331 ± 0.029, ZP = −23.94 ± 1.64 mV, and EE% = 95.4 ± 2.56%. Molecular modeling indicated hydrophobic and electrostatic interactions between CA and CS, accounting for the high EE%. Almost spherical particles were realized with a sustained CA release pattern. Optimized NPs effectively suppressed the growth of MCF-7 cell lines by scoring the lowest IC50 = 78.45 ± 1.7 µg/mL. A novel combination of bioinspired-derived materials was developed for use in breast cancer treatment. Full article

(This article belongs to the Topic Complementary Strategies in Drug Delivery: From Particle Engineering to System Optimization)

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20 pages, 2334 KiB  

Open AccessArticle

Phosal^® Curcumin-Loaded Nanoemulsions: Effect of Surfactant Concentration on Critical Physicochemical Properties

by Joanna Czerniel, Aleksandra Gostyńska, Tomasz Przybylski and Maciej Stawny

Sci. Pharm. 2024, 92(3), 48; https://doi.org/10.3390/scipharm92030048 - 30 Aug 2024

Viewed by 903

Abstract

Curcumin is a well-known and widely used substance of natural origin. It has also been found to be helpful in the treatment of liver diseases. Unfortunately, curcumin has very low bioavailability and a sensitivity to external agents. Improving these parameters is the subject [...] Read more.

Curcumin is a well-known and widely used substance of natural origin. It has also been found to be helpful in the treatment of liver diseases. Unfortunately, curcumin has very low bioavailability and a sensitivity to external agents. Improving these parameters is the subject of many studies. One way to overcome these problems may be to use Phosal^® Curcumin as a source of curcumin and encapsulate this dispersion into a nanoemulsion using different types and concentrations of surfactants and co-surfactants, thus manipulating the physicochemical parameters of the nanoemulsion. The present study aimed to develop curcumin-loaded nanoemulsions for intravenous administration and to investigate the effect of Kolliphor HS15 concentration on their critical quality attributes. Methods: Phosal^® Curcumin-loaded nanoemulsions with different concentrations of Kolliphor HS15 were prepared by high-pressure homogenization. The effect of Kolliphor HS15 on emulsion physicochemical properties such as mean droplet diameter (MDD), polydispersity index (PDI), zeta potential (ZP), osmolality (OSM), and pH, as well as encapsulation efficiency (EE) and retention rate (RR) of curcumin, were determined. Mid-term stability studies and short-term stress tests were conducted to evaluate the impact of Kolliphor HS15 on the critical quality attributes of the curcumin-loaded nanoemulsions stored under various conditions. Results: Five nanoemulsions with increasing Kolliphor HS15 concentrations were developed. Their MDD ranged from 85.2 ± 2.0 to 154.5 ± 5.1 nm, with a PDI from 0.18 ± 0.04 to 0.10 ± 0.01 and ZP from −15.6 ± 0.7 to −27.6 ± 3.4 mV. Depending on the concentration of Kolliphor HS15, the EE ranged from 58.42 ± 1.27 to 44.98 ± 0.97%. Conclusions: The studied parameters of the developed nanoemulsions meet the requirements for formulations for intravenous administration. Using the appropriate concentration of Kolliphor HS15 allows for a formulation that presents a protective effect against both curcumin and emulsion degradation. Full article

(This article belongs to the Topic Complementary Strategies in Drug Delivery: From Particle Engineering to System Optimization)

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