The Hypopigmentation Mechanism of Tyrosinase Inhibitory Peptides Derived from Food Proteins: An Overview
Round 1
Reviewer 1 Report
The manuscript of molecules-1684166 reviewed the hypopigmentation mechanism of tyrosinase inhibititory peptides derived from food proteins. The manuscript fits into the research area that Molecules deals with and meets the general standards for publication. Then, I think the paper can be acceptable for publication in Molecules after a minor revision.
(1) It is suggested that the author add the content of peptide preparation to make the article more complete.
(2) The author made a detailed review of the existing research, and suggested that the author could put forward the existing problems and prospects for the future more clearly on this basis.
Author Response
Dear reviewer,
Thanks for your comments. The point-to-point response to your every comment is shown. Thank you again and hope you a nice day!
Sincerely,
Xiao Hu
The manuscript of molecules-1684166 reviewed the hypopigmentation mechanism of tyrosinase inhibitory peptides derived from food proteins. The manuscript fits into the research area that Molecules deals with and meets the general standards for publication. Then, I think the paper can be acceptable for publication in Molecules after a minor revision.
- It is suggested that the author add the content of peptide preparation to make the article more complete.
Response: Thanks for your comments. We have added a section named “3. The preparation of anti-tyrosinase peptides from food protein” (Line 142-199) and several summary sentances at the terminal of article (Line 525-528) to elaborate the preparation methods of TIPs, aiming to make the paper more complete.
The author made a detailed review of the existing research, and suggested that the author could put forward the existing problems and prospects for the future more clearly on this basis.
Response: Thanks for your comments. We have added some sentences to elaborate the existing problems and prospects for the future (Line 539-550 and Line 557-562) to make paper more clearly.
Reviewer 2 Report
Review Report
The review entitled “The hypopigmentation mechanism of tyrosinase inhibititory peptides derived from food proteins: An overview” authored by Yuqiong Song et al presents emerging bioinformatic technologies used in developing new tyrosinase inhibitors as well as main mechanisms for tyrosinase food-origin peptide-induced inhibition. Tyrosinase activity and its control is an issue that concerns many scientific fields such as chemistry, biology and medicine since it is related with Skin hyperpigmentation.
The review paper is clear, comprehensive and unique. Information is presented by the authors in a well-structured manner and informative tables and figures and up to date cite references have been used.
The conclusions are based on the experimental evidence. Authors present the knowledge in a well-organized way, indicating various sources of food-origin tyrosinase inhibitors and specific possible mechanisms for tyrosinase inhibition. the authors critically explain the meaning of the so far knowledge, helping in this way other researchers to go further
The review may be accepted in its present Form
Comments for author File: 
Comments.pdf
Author Response
Dear reviewer,
Thanks for your comments. The point-to-point response to your every comment is shown. Thank you again and hope you a nice day!
Sincerely,
Xiao Hu
Reviewer #2:
The review entitled “The hypopigmentation mechanism of tyrosinase inhibititory peptides derived from food proteins: An overview” authored by Yuqiong Song et al presents emerging bioinformatic technologies used in developing new tyrosinase inhibitors as well as main mechanisms for tyrosinase food-origin peptide-induced inhibition. Tyrosinase activity and its control is an issue that concerns many scientific fields such as chemistry, biology and medicine since it is related with Skin hyperpigmentation.
The review paper is clear, comprehensive and unique. Information is presented by the authors in a well-structured manner and informative tables and figures and up to date cite references have been used.
The conclusions are based on the experimental evidence. Authors present the knowledge in a well-organized way, indicating various sources of food-origin tyrosinase inhibitors and specific possible mechanisms for tyrosinase inhibition. the authors critically explain the meaning of the so far knowledge, helping in this way other researchers to go further.
The review may be accepted in its present Form.
Response: Thanks for your comments.
