Pathogenesis, Diagnostic Modalities, Biomechanical Markers and Multimodal Therapeutic Strategies of Equine Orthopedic Diseases

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Equids".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 1239

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Guest Editor
Department of Veterinary Sciences, University of Turin, Turin, Italy
Interests: equine sports medicine; horse locomotion; gait analysis, inertial sensors; electromyography; wearable sensors; welfare in racehorses
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Guest Editor
Private Practice, Novara, Italy
Interests: equine sports medicine; innovation in equine rehabilitation; equine kinesiology taping; posture and function; welfare in sport-horses
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Special Issue Information

Dear Colleagues,

Equine orthopedic diseases are a major cause of economic loss in the equine industry and a significant concern for horse owners and veterinarians, and can also cause significant pain, lameness, and decreased athletic performance in affected animals.

The pathogenesis of equine orthopedic diseases can vary depending on the specific condition, but often involves a combination of mechanical stress, inflammation, and genetic predisposition. Accurate diagnosis is critical for effective treatment, and a range of diagnostic modalities are available, including radiography, ultrasonography, magnetic resonance imaging, and computed tomography.

Biomechanical markers can also be useful for predicting and monitoring disease progression, and may include measures such as force plate analysis, gait analysis, and joint kinematics. In order to make the gait analysis more doable and affordable in field practice, some companies are now focusing on the creation of apps that can be used on smartphones to facilitate the collection of objective data.

Multimodal therapeutic strategies are often necessary for managing equine orthopedic diseases and may include a combination of medical and surgical interventions, rehabilitation, and alternative therapies such as acupuncture and stem cell therapy.

We invite original research and review papers that aim to provide a comprehensive overview of the pathogenesis, diagnostic modalities, biomechanical markers, and multimodal therapeutic strategies for these conditions.

Dr. Andrea Bertuglia
Dr. Sybille Molle
Guest Editors

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Keywords

  • lameness
  • gait analysis
  • orthopedic disease
  • equine rehabilitation
  • posture and function
  • equine therapy
  • multimodal approach
  • diagnostic imaging

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Published Papers (1 paper)

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Research

14 pages, 1942 KiB  
Article
Revealing the Therapeutic Potential of Muscle-Derived Mesenchymal Stem/Stromal Cells: An In Vitro Model for Equine Laminitis Based on Activated Neutrophils, Anoxia–Reoxygenation, and Myeloperoxidase
by Didier Serteyn, Nazaré Storms, Ange Mouithys-Mickalad, Charlotte Sandersen, Ariane Niesten, Julien Duysens, Hélène Graide, Justine Ceusters and Thierry Franck
Animals 2024, 14(18), 2681; https://doi.org/10.3390/ani14182681 - 14 Sep 2024
Viewed by 837
Abstract
Laminitis in horses is a crippling condition marked by the deterioration of the dermal–epidermal interface, leading to intense lameness and discomfort, often necessitating euthanasia. This study aimed to establish an in vitro model of laminitis using a continuous keratinocyte cell line exposed to [...] Read more.
Laminitis in horses is a crippling condition marked by the deterioration of the dermal–epidermal interface, leading to intense lameness and discomfort, often necessitating euthanasia. This study aimed to establish an in vitro model of laminitis using a continuous keratinocyte cell line exposed to anoxia–reoxygenation and an activated neutrophil supernatant. A significant decrease in the keratinocytes’ metabolism was noted during the reoxygenation period, indicative of cellular stress. Adding muscle-derived mesenchymal stem/stromal cells during the reoxygenation demonstrated a protective effect, restoring the keratinocytes’ metabolic activity. Moreover, the incubation of the keratinocytes with either an activated neutrophil supernatant or myeloperoxidase alone induced increased keratinocyte myeloperoxidase activity, which was modulated by stem cells. These findings underscore the potential of muscle-derived mesenchymal stem/stromal cells in mitigating inflammation and restoring keratinocyte metabolism, offering insights for future cell therapy research in laminitis treatment. Full article
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