Advances in Animal Oncology: Diagnostic Innovations, Therapeutic Approaches, and One Health Perspectives

A special issue of Animals (ISSN 2076-2615).

Deadline for manuscript submissions: 30 April 2025 | Viewed by 538

Special Issue Editors


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Guest Editor
Unit of Pathology, Department of Veterinary Medicine, University of Naples Federico II, Naples, Italy
Interests: veterinary pathology; onco-epidemiology; animal cancer registry; comparative oncology; veterinary forensic pathology; medicine
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137 Napoli, Italia
Interests: veterinary pathology; onco-epidemiology; animal cancer registry; comparative oncology

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Guest Editor
1. CECAV-Veterinary and Animal Research Center, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal
2. Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 5000-801 Vila Real, Portugal
3. Veterinary Sciences Department, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal
Interests: pathology; veterinary forensics; oncology; wildlife conservation; animal cancer registry; immunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is a disease that affects almost all animal species. The way neoplasms are considered has changed over time in the scientific community. The tumor cell is no longer the protagonist in the biological behavior of the neoplasm but is part of a complex ecosystem in which several players can influence or even dictate the prognosis of the animal. The number of animals diagnosed with cancer has increased, partly because of improved diagnostic methods and, consequently, early detection of tumors. Furthermore, there has been an increase in research into new diagnostic methods and molecular targets that can be converted into new therapies after clinical trials.

The study of cancer in animals has attracted the attention of the scientific community and is already regarded under a One Health perspective. Animal-based studies are also key to the evolution of precision medicine, an approach to disease prevention and treatment that focuses on the individual and considers individual differences in genes, environment, and lifestyle.

Original manuscripts on every aspect of neoplasia and cancer in animals are invited to this Special Issue. Topics of particular interest include new diagnostic methods, therapeutic tools, therapeutic drugs, animal tumor comparative approaches, rare tumors, palliative care, and other topics.

Prof. Dr. Orlando Paciello
Dr. Evaristo Di Napoli
Dr. Isabel Pires
Dr. Filipe da Costa Silva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • diagnosis
  • therapeutic
  • precision medicine
  • One Health

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Published Papers (1 paper)

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Research

14 pages, 9919 KiB  
Article
Immunohistochemical Investigation of Cyclooxygenase-2 Expression in Rabbit Uterine Adenocarcinoma and the Potential Use of COX-2 Inhibitors in Cancer Therapy
by Emanuela Vaccaro, Luigi Navas, Martina Ercolano, Giuseppe Piegari, Evaristo Di Napoli, Serenella Papparella, Donato Inverso, Barbara Brunetti, Orlando Paciello and Valeria Russo
Animals 2024, 14(22), 3169; https://doi.org/10.3390/ani14223169 - 6 Nov 2024
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Abstract
Cyclooxygenase-2 (COX-2) is overexpressed in many human and animal cancers. Selective COX-2 inhibitors have shown antitumoral effects in tumors with a high expression of COX-2. This study evaluates (1) the expression of COX-2 in rabbit uterine adenocarcinomas, (2) the correlation between immunophenotypic expression [...] Read more.
Cyclooxygenase-2 (COX-2) is overexpressed in many human and animal cancers. Selective COX-2 inhibitors have shown antitumoral effects in tumors with a high expression of COX-2. This study evaluates (1) the expression of COX-2 in rabbit uterine adenocarcinomas, (2) the correlation between immunophenotypic expression and histopathological changes, and (3) the post-surgery response to therapy with COX-2 inhibitors. Forty rabbit uteri were divided into three groups: neoplastic, hyperplastic, and normal endometrium. A histological and immunohistochemical score was applied to investigate the tumor’s grade and the COX-2 expression. By histological evaluation, 30 cases of endometrial adenocarcinoma, 5 cases of endometrial hyperplasia and 5 normal endometria were found. Of the six cases of endometrial adenocarcinoma with follow-up available, four received a post-surgical treatment with meloxicam and two were treated by surgery alone. The survival time of the animals treated with meloxicam was longer than that observed in the untreated animals. A statistically significant difference in COX-2 IHS was observed between non-neoplastic endometrium and adenocarcinoma. The progressive increase in COX-2 expression from normal epithelium to carcinoma suggests that upregulation of COX-2 expression may play a role in tumor initiation and progression. Our findings suggest the possible use of COX-2 inhibitors in treating uterine adenocarcinoma in rabbits. Further study will be needed to confirm this hypothesis. Full article
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