Advances in Small Ruminant Pathology: A Focus on Prevention and Diagnosis

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Small Ruminants".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 1373

Special Issue Editors


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Guest Editor
Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canaria, Spain
Interests: ruminants; surgery; internal medicine; livestock; camels; parasitology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canaria, Spain
Interests: mycoplasmas

Special Issue Information

Dear Colleagues,

In the field of livestock production, the most significant health concerns revolve around viral and bacterial infections, as well as parasitic diseases. Hence, understanding the pathology of small ruminants holds utmost importance across various domains such as veterinary sciences and livestock management. This comprehension enables the development of appropriate disease management techniques, the formulation of vaccines, and the improvement of overall herd health and productivity.
By mitigating the effects of avoidable and manageable illnesses in livestock, the field of pathology actively fosters a healthier outlook for all animals, while concurrently enhancing the economic prospects for farmers.

We invite original research papers showcasing the latest advancements in understanding, preventing, and diagnosing diseases affecting small ruminants. Whether it is about discovering new causes of diseases, exploring innovative vaccination strategies, or uncovering how diseases interact with their hosts, we are eager to feature research that leads us toward more effective prevention measures.

Dr. Sergio Martín
Dr. Ruben Rosales
Guest Editors

Manuscript Submission Information

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Keywords

  • goat
  • sheep
  • small ruminants
  • livestock
  • diagnosis
  • prevention
  • metaphylaxis
  • prophylaxis
  • vaccines
  • protection

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Published Papers (1 paper)

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Research

18 pages, 3568 KiB  
Article
No Evidence of Neutrophil Response Modulation in Goats after Immunization against Paratuberculosis with a Heat-Inactivated Vaccine
by Miguel Criado, Marta Silva, Pedro Mendívil, Elena Molina, Valentín Pérez, Julio Benavides, Natalia Elguezabal and Daniel Gutiérrez-Expósito
Animals 2024, 14(11), 1694; https://doi.org/10.3390/ani14111694 - 5 Jun 2024
Viewed by 1085
Abstract
Neutrophils are believed to play a role in the initial stages of paratuberculosis, and it has recently been demonstrated that vaccination can modulate their function via priming or through epigenetic and metabolic reprogramming (training). Modulation of the neutrophil response against Mycobacterium avium subspecies [...] Read more.
Neutrophils are believed to play a role in the initial stages of paratuberculosis, and it has recently been demonstrated that vaccination can modulate their function via priming or through epigenetic and metabolic reprogramming (training). Modulation of the neutrophil response against Mycobacterium avium subspecies paratuberculosis (Map) through vaccination has been demonstrated in a rabbit model but not in ruminants. Therefore, in the present work, the effect of vaccination on the response of caprine neutrophils against Map was studied. Neutrophils were isolated from non-vaccinated (n = 7) and Gudair®-vaccinated goat kids (n = 7), before vaccination and 30 days post-vaccination. Then, several neutrophil functions were quantified ex vivo: cell-free and anchored neutrophil extracellular trap (NET) release, phagocytosis, and the differential expression of several cytokines and TLR2. The induction of cell-free NETosis and TLR2 expression by Map is reported for the first time. However, vaccination showed no significant effect on any of the functions studied. This suggests that the protection conferred by Gudair® vaccination is based on mechanisms that are independent of the neutrophil function modulation. Further research into the impact of alternative vaccination strategies or the paratuberculosis infection stage on ruminant neutrophil function could provide valuable insights into its role in paratuberculosis. Full article
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