Exploring Biomarkers of Oxidative Stress in Health and Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 20 March 2025 | Viewed by 1254
Special Issue Editors
Interests: oxidative stress; cardiometabolic diseases; ageing; lipoprotein metabolism; drug metabolism; geroprotectors
Interests: effects of natural/synthetic compounds on cellular pathways; oxidative stress; cardiometabolic disease
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Special Issue Information
Dear Colleagues,
For forty decades, the concept of oxidative stress has remained an important focus of interest in biomedical research, and limiting oxidative stress intensity became a cutting-edge therapeutic goal of pharmaceutical research. This imbalance in redox homeostasis and the consequent oxidative damage accumulation in macromolecules has been considered as a cause of cellular impairment, being associated with numerous risk factors of several diseases, with age-related pathological conditions as well as with normal ageing. This continuous interest in oxidative stress is also highlighted by the development of new molecules, such as dimethyl fumarate, that act through signalling pathways modulating redox homeostasis (e.g., Nrf2) and that are used as targeted therapy against severe diseases (multiple sclerosis).
In this Special Issue, the main emphasis will be on the relevance of oxidative stress biomarkers assessed under specific physiopathological/toxicological situations such as metabolic dysregulations (dyslipidaemia, chronic hyperglycaemia, hyperinsulinaemia, hyperuricaemia), intoxications, or environmental exposure to harmful agents (cigarette smoking, pollutants, UV and ionizing irradiation). This approach is necessary since redox imbalance pathways and oxidative stress biomarkers are studied extensively and considered as new targets in prevention, diagnosis and therapy for cardiometabolic diseases (cardiovascular diseases, type 2 diabetes mellitus, metabolic syndrome and obesity), neurodegenerative disorders, cancer, inflammation, and also as candidate biomarkers in evaluating the human biological age.
We invite investigators to contribute with critical reviews and original research articles concerning the most recent advances in the study of oxidative stress biomarkers which emerged as relevant tools for the investigation and diagnosis of oxidopathies and for monitoring the efficiency of antioxidant therapies in clinical samples or experimental models.
Potential topics include, but are not limited to, the following:
- Lipid and lipoprotein oxidation markers;
- Protein oxidation and glycoxidation;
- Protein carbonylation, nitration and chlorination;
- Protein glutathionylation;
- DNA/RNA oxidative damage;
- Enzymatic and non-enzymatic antioxidant defence;
- Antioxidant status/properties;
- Redox cellular/molecular pathways.
Prof. Dr. Daniela Gradinaru
Prof. Dr. Denisa Marilena Margină
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxidative and nitrosative stress
- AGEs—advanced glycation end-products
- lipid peroxidation
- nitrotyrosine
- glutathione
- 8-oxo-2'-deoxyguanosine
- inflammation
- cardiometabolic risk
- cancer
- neurodegeneration
- nanoparticles
- xenobiotic
- antioxidant
- ageing
- advanced therapies
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