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Antioxidants
Special Issues
Antioxidants as Anti-Aging Interventions
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Antioxidants as Anti-Aging Interventions

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 3529

Special Issue Editors

Dr. Dimitris Kletsas

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Guest Editor
Laboratory of Cell Proliferation & Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research “Demokritos”, 15341 Aghia Paraskevi, Greece
Interests: molecular-cellular ageing; age-related diseases; carcinogenesis
Special Issues, Collections and Topics in MDPI journals
Dr. Marianna Kapetanou

E-Mail Website
Guest Editor
Hellenic Pasteur Institute, 127 Vasilissis Sofias Avenue, 11521 Athens, Greece
Interests: molecular ageing; proteostasis; Ssem cell biology; natural bioactive compounds; anti-ageing interventions
Dr. Aleksandra Mladenovic

E-Mail Website
Guest Editor
Department of Neurobiology, Institute for Biological Research “Sinisa Stankovic”—National Institute of Republic of Serbia, University of Belgrade, Bul.D. Stefana 142, 11000 Belgrade, Serbia
Interests: neurodegenerative diseases; brain ageing; frailty; environmental interventions to postpone ageing

Special Issue Information

Dear Colleagues,

Ageing is currently defined as a dynamic process that involves the gradual and global accumulation of biological dysfunctions, resulting in the failure of homeostasis, increased sensitivity to all major chronic diseases, including neurodegeneration and cardiovascular disease, frailty, and eventually death. In recent years, scientific researchers have attempted to develop theories that explain the ageing process and define its molecular basis. Continuous, unrepaired oxidative damage has been implicated in several hallmarks of ageing, including loss of proteostasis, telomere shortening, DNA damage accumulation, and cellular senescence. This close relationship between oxidative damage and the ageing process has been established in various model systems, while the improvement of anti-oxidant defenses and dietary antioxidants are capable of extending the (healthy) lifespan of model organisms and alleviating the pathology of age-related diseases. A deep understanding of the molecular pathways involved in redox balance and the identification of the optimal conditions for antioxidant modulation will be crucial for successful clinical applications.

We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together the current research concerning the role of redox status manipulation to alleviate ageing and the relevant disease states. This research can include both in vitro and in vivo studies related to any of the following topics: antioxidants, nutraceuticals, diet, regulation of redox homeostasis, proteostasis, cellular stress, ageing and age-related disease, neuroscience, cell signaling and metabolism, bioenergetics, hormesis.

We look forward to your contributions.

Dr. Dimitris Kletsas
Dr. Marianna Kapetanou
Dr. Aleksandra Mladenovic
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ageing
  • antioxidants
  • homeostasis
  • nutraceuticals
  • diet
  • disease

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Published Papers (2 papers)

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14 pages, 2818 KiB  
Article
α-Terpineol Induces Shelterin Components TRF1 and TRF2 to Mitigate Senescence and Telomere Integrity Loss via A Telomerase-Independent Pathway
by Marianna Kapetanou, Sophia Athanasopoulou, Andreas Goutas, Dimitra Makatsori, Varvara Trachana and Efstathios Gonos
Antioxidants 2024, 13(10), 1258; https://doi.org/10.3390/antiox13101258 - 17 Oct 2024
Viewed by 717
Abstract
Cellular senescence is a hallmark of aging characterized by irreversible growth arrest and functional decline. Progressive telomeric DNA shortening in dividing somatic cells, programmed during development, leads to critically short telomeres that trigger replicative senescence and thereby contribute to aging. Therefore, protecting telomeres [...] Read more.
Cellular senescence is a hallmark of aging characterized by irreversible growth arrest and functional decline. Progressive telomeric DNA shortening in dividing somatic cells, programmed during development, leads to critically short telomeres that trigger replicative senescence and thereby contribute to aging. Therefore, protecting telomeres from DNA damage is essential in order to avoid entry into senescence and organismal aging. In several organisms, including mammals, telomeres are protected by a protein complex named shelterin that prevents DNA damage at the chromosome ends through the specific function of its subunits. Here, we reveal that the nuclear protein levels of shelterin components TRF1 and TRF2 decline in fibroblasts reaching senescence. Notably, we identify α-terpineol as an activator that effectively enhances TRF1 and TRF2 levels in a telomerase-independent manner, counteracting the senescence-associated decline in these crucial proteins. Moreover, α-terpineol ameliorates the cells’ response to oxidative DNA damage, particularly at the telomeric regions, thus preserving telomere length and delaying senescence. More importantly, our findings reveal the significance of the PI3K/AKT pathway in the regulation of shelterin components responsible for preserving telomere integrity. In conclusion, this study deepens our understanding of the molecular pathways involved in senescence-associated telomere dysfunction and highlights the potential of shelterin components to serve as targets of therapeutic interventions, aimed at promoting healthy aging and combating age-related diseases. Full article
(This article belongs to the Special Issue Antioxidants as Anti-Aging Interventions)
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15 pages, 3881 KiB  
Article
Pomegranate Extract Administration Reverses Loss of Motor Coordination and Prevents Oxidative Stress in Cerebellum of Aging Mice
by David Verdú, Alicia Valls, Ana Díaz, Aitor Carretero, Mar Dromant, Julia Kuligowski, Eva Serna and José Viña
Antioxidants 2023, 12(11), 1991; https://doi.org/10.3390/antiox12111991 - 11 Nov 2023
Cited by 1 | Viewed by 2179
Abstract
The cerebellum is responsible for complex motor functions, like maintaining balance and stance, coordination of voluntary movements, motor learning, and cognitive tasks. During aging, most of these functions deteriorate, which results in falls and accidents. The aim of this work was to elucidate [...] Read more.
The cerebellum is responsible for complex motor functions, like maintaining balance and stance, coordination of voluntary movements, motor learning, and cognitive tasks. During aging, most of these functions deteriorate, which results in falls and accidents. The aim of this work was to elucidate the effect of a standardized pomegranate extract during four months of supplementation in elderly mice to prevent frailty and improve the oxidative state. Male C57Bl/6J eighteen-month-old mice were evaluated for frailty using the “Valencia Score” at pre-supplementation and post-supplementation periods. We analyzed lipid peroxidation in the cerebellum and brain cortex and the glutathione redox status in peripheral blood. In addition, a set of aging-related genes in cerebellum and apoptosis biomarkers was measured via real-time polymerase chain reaction (RT-PCR). Our results showed that pomegranate extract supplementation improved the motor skills of C57Bl/6J aged mice in motor coordination, neuromuscular function, and monthly weight loss, but no changes in grip strength and endurance were found. Furthermore, pomegranate extract reversed the increase in malondialdehyde due to aging in the cerebellum and increased the reduced glutathione/oxidized glutathione (GSH/GSSG) ratio in the blood. Finally, aging and apoptosis biomarkers improved in aged mice supplemented with pomegranate extract in the cerebellum but not in the cerebral cortex. Full article
(This article belongs to the Special Issue Antioxidants as Anti-Aging Interventions)
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