Oxidative Stress in Gut Microbiota

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 1275

Special Issue Editor


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Guest Editor
Department of Pharmacology, Jiangnan University, Wuxi 214122, China
Interests: anti-inflammatory immunopharmacology; pancreatitis; gut microbiota; intestinal inflammatory diseases
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Special Issue Information

Dear Colleagues,

Oxidative stress plays a crucial role in the onset and development of many inflammatory diseases, including cardiovascular disease, digestive system diseases, and so on. Gut microbiota can produce metabolites or antioxidant substances, such as antioxidant enzymes and vitamins, to maintain oxidative balance within the intestine. These metabolites or antioxidant substances inhibit the process of oxidative stress, protecting intestinal epithelial cells from oxidative damage and maintaining the integrity and function of the intestinal mucosa. On the other hand, gut dysbiosis may produce toxic metabolites, triggering oxidative stress in the host, damaging intestinal epithelial cells, and causing inflammation in intestinal diseases or diseases in distal organs. Additionally, some intestinal bacteria can translocate through the intestinal barrier and affect other organs or tissues.

This Special Issue will deepen our understanding of the intricate interplay between the gut microbiota and oxidative stress and its role in the development of inflammatory diseases. We encourage researchers to submit original research articles, reviews, and meta-analyses focusing on various aspects of oxidative stress under the background of gut microbiota and provide potential approaches for therapeutic interventions in related inflammatory diseases. Certainly, research on the role of natural products in modulating the interplay between gut microbiota and oxidative stress in disease onset is highly encouraged. Research involving human subjects, animal models, and in vitro experiments are all within the scope of this Special Issue.

Prof. Dr. Lilong Pan
Guest Editor

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Keywords

  • oxidative stress
  • inflammatory diseases
  • antioxidants
  • antimicrobial activity
  • microbiota metabolites
  • natural products

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Published Papers (1 paper)

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Research

21 pages, 5039 KiB  
Article
Analysis of the Preventive Effect of Lonicera caerulea Pomace and Its Isolated Components on Colitis in Mice Based on Gut Microbiota and Serum Metabolomics
by Zinuo Zhou, Xinwen Huang and Baixi Zhang
Antioxidants 2024, 13(12), 1478; https://doi.org/10.3390/antiox13121478 - 30 Nov 2024
Viewed by 919
Abstract
Inflammatory bowel disease (IBD), including relapsing-remitting ulcerative colitis and Crohn’s disease, is a non-specific chronic intestinal inflammatory disease. Lonicera caerulea, which is rich in polyphenolic compounds, has been shown to exert antioxidative and anti-inflammatory effects. The research evaluates the dietary impacts of [...] Read more.
Inflammatory bowel disease (IBD), including relapsing-remitting ulcerative colitis and Crohn’s disease, is a non-specific chronic intestinal inflammatory disease. Lonicera caerulea, which is rich in polyphenolic compounds, has been shown to exert antioxidative and anti-inflammatory effects. The research evaluates the dietary impacts of Lonicera caerulea pomace, its polyphenol-rich extract, and fiber-rich residue on colitis symptoms. Colitis was induced with 2.5% DSS (dextran sulfate sodium) aqueous solution after continuous feeding of customized Lonicera caerulea feed for 2.5 weeks. The results indicate that the intake of the polyphenol-rich extract has an effect in preventing colitis in mice, but the effect is less than that by the pomace itself, and the fiber residue alone does not prevent the condition when ingested. The pomace and polyphenol-rich extract have a positive regulatory effect on the gut microbiota of mice with colitis, and the intake of Lonicera caerulea pomace significantly restores 15 metabolites in mice with colitis, significantly improving five metabolic pathways, including steroid biosynthesis, with the regulation of metabolites and metabolic pathways being significantly correlated with the gut microbiota. Full article
(This article belongs to the Special Issue Oxidative Stress in Gut Microbiota)
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