The Role of Redox Modulation by Natural Agents under Steady State or Inflammatory Conditions
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 5826
Special Issue Editors
Interests: anti-inflammatory immunopharmacology; pancreatitis; gut microbiota; intestinal inflammatory diseases
Special Issues, Collections and Topics in MDPI journals
Interests: inflammation; acute pancreatitis; sepsis; burn injury; arthritis; hydrogen sulfide; substance P; chemokines; leukocytes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Reactive oxygen species (ROS) generated under physiological conditions are essential to maintain cell homeostasis. However, excessive ROS generation can result in oxidative stress and activate redox-sensitive signaling pathways, thereby provoking the onset and progression of various inflammation-related diseases, i.e., cardiovascular disease, diabetes, neurodegenerative diseases, etc.
Recent findings suggest the crucial role of natural agents, especially intestinal flora metabolites, endogenous active substances, and natural compounds with definite structure, in the regulation of various inflammation-related diseases by modulating oxidative stress. Meanwhile, recent evidence has highlighted specific natural agents as a potential therapeutic strategy for modulating oxidative stress and treating inflammation-related diseases. Meanwhile, despite extensive research efforts, the detailed mechanisms of natural agents on maintaining redox homeostasis or mediating inflammation-related diseases remain to be fully understood.
In this Special Issue of Antioxidants (MDPI), we welcome investigators to contribute original research articles reporting data from both experimental and clinical studies, as well as review articles that provide a better understanding of modulatory effects and underlying mechanisms of natural agents on oxidative stress-mediated inflammation and related disease development. It should be noted that for studies involving natural extracts, an accurate chemical and quantitative characterization (using analytical methodologies, such as HPLC, MS, LC–MS, HPLC–MS, and NMR) of active compounds in the extracts is required. In addition, basic and mechanistic research on redox modulation by natural agents under steady state is also welcome.
Dr. Lilong Pan
Prof. Dr. Madhav Bhatia
Guest Editors
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Keywords
- redox homeostasis
- cell homeostasis
- physiological conditions
- reactive oxygen species
- ROS
- oxidative stress
- inflammation
- diseases
- cardiovascular disease
- diabetes
- neurodegenerative diseases
- mechanisms of natural agents
- natural compounds
- intestinal flora metabolites
- endogenous active substances
- potential therapeutic strategy
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