Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
10.6
6.0
Journals
Antioxidants
Special Issues
Non-Coding RNAs and Reactive Oxygen Species
share announcement

Non-Coding RNAs and Reactive Oxygen Species

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 3674

Special Issue Editor

Dr. Rosalia Battaglia

E-Mail Website
Guest Editor
Department of Biomedical and Biotechnological Sciences, Section of Biology & Genetics "G. Sichel", University of Catania, via S. Sofia 97, 95123 Catania, Italy
Interests: molecular biology; reproductive biology; oocyte maturation; embryo implantation; genetics and epigenetics of reproductive disorders; non-coding RNAs; microRNAs; gene expression; cell culture; real-time PCR; molecular genetics; RNA isolation; DNA extraction; exosomes isolation

Special Issue Information

Dear Colleagues,

The cellular transcriptome consists of a diverse array of untranslated RNAs. Non-coding RNAs (ncRNAs) have emerged as crucial regulators in various cellular processes, such as gene regulation, epigenetic modifications, and cellular signaling. Over the past few years, mounting evidence has implicated ncRNAs in modulating reactive oxygen species (ROS) dynamics within cells. ROS, comprising superoxide anion, hydrogen peroxide, and hydroxyl radicals, are natural byproducts of cellular metabolism that function as signaling molecules under normal physiological conditions. However, excessive ROS production or impaired ROS detoxification mechanisms can result in oxidative stress, leading to cellular damage and diverse diseases.

The objective of this Special Issue is to explore the intricate relationship between ncRNAs and ROS, with a particular focus on the effects of ncRNAs on mitochondrial function, ROS production, and apoptosis in human cells, shedding light on the regulatory roles of ncRNAs in cellular homeostasis and disease pathogenesis.

We look forward to receiving your contributions.

Dr. Rosalia Battaglia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • non-coding RNAs
  • ncRNAs
  • ROS
  • mitochondrial function
  • gene regulation
  • epigenetic modifications

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

18 pages, 1703 KiB  
Review
miRNAs Involvement in Modulating Signalling Pathways Involved in Ros-Mediated Oxidative Stress in Melanoma
by José Daniel Escobar Moreno, José Luis Fajardo Castiblanco, Laura Camila Riaño Rodriguez, Paula Marcela Barrios Ospina, Carlos Andrés Zabala Bello, Esther Natalia Muñoz Roa and Hernán Mauricio Rivera Escobar
Antioxidants 2024, 13(11), 1326; https://doi.org/10.3390/antiox13111326 - 30 Oct 2024
Viewed by 1011
Abstract
Reactive oxygen species (ROS) are intermediates in oxidation–reduction reactions with the capacity to modify biomolecules and temporarily or permanently alter cell behaviour through signalling pathways under physiological and pathophysiological conditions where there is an imbalance between oxidative factors and the antioxidant response of [...] Read more.
Reactive oxygen species (ROS) are intermediates in oxidation–reduction reactions with the capacity to modify biomolecules and temporarily or permanently alter cell behaviour through signalling pathways under physiological and pathophysiological conditions where there is an imbalance between oxidative factors and the antioxidant response of the organism, a phenomenon known as oxidative stress. Evidence suggests that the differential modulation of ROS-mediated oxidative stress occurs in the pathogenesis and progression of melanoma, and that this imbalance in redox homeostasis appears to be functionally linked to microRNA (miRNA o miRs)-mediated non-mutational epigenetic reprogramming involving genes and transcription factors. The relationship between ROS-mediated stress control, tumour microenvironment, and miRNA expression in melanoma is not fully understood. The aim of this review is to analyse the involvement of miRNAs in the modulation of the signalling pathways involved in ROS-mediated oxidative stress in melanoma. It is hoped that these considerations will contribute to the understanding of the mechanisms associated with a potential epigenetic network regulation, where the modulation of oxidative stress is consolidated as a common factor in melanoma, and therefore, a potential footprint poorly documented. Full article
(This article belongs to the Special Issue Non-Coding RNAs and Reactive Oxygen Species)
►▼ Show Figures

Figure 1

18 pages, 3787 KiB  
Review
Building a Human Ovarian Antioxidant ceRNA Network “OvAnOx”: A Bioinformatic Perspective for Research on Redox-Related Ovarian Functions and Dysfunctions
by Carla Tatone, Giovanna Di Emidio, Rosalia Battaglia and Cinzia Di Pietro
Antioxidants 2024, 13(9), 1101; https://doi.org/10.3390/antiox13091101 - 12 Sep 2024
Viewed by 760
Abstract
The ovary is a major determinant of female reproductive health. Ovarian functions are mainly related to the primordial follicle pool, which is gradually lost with aging. Ovarian aging and reproductive dysfunctions share oxidative stress as a common underlying mechanism. ROS signaling is essential [...] Read more.
The ovary is a major determinant of female reproductive health. Ovarian functions are mainly related to the primordial follicle pool, which is gradually lost with aging. Ovarian aging and reproductive dysfunctions share oxidative stress as a common underlying mechanism. ROS signaling is essential for normal ovarian processes, yet it can contribute to various ovarian disorders when disrupted. Therefore, balance in the redox system is crucial for proper ovarian functions. In the present study, by focusing on mRNAs and ncRNAs described in the ovary and taking into account only validated ncRNA interactions, we built an ovarian antioxidant ceRNA network, named OvAnOx ceRNA, composed of 5 mRNAs (SOD1, SOD2, CAT, PRDX3, GR), 10 miRNAs and 5 lncRNAs (XIST, FGD5-AS1, MALAT1, NEAT1, SNHG1). Our bioinformatic analysis indicated that the components of OvAnOx ceRNA not only contribute to antioxidant defense but are also involved in other ovarian functions. Indeed, antioxidant enzymes encoded by mRNAs of OvAnOx ceRNA operate within a regulatory network that impacts ovarian reserve, follicular dynamics, and oocyte maturation in normal and pathological conditions. The OvAnOx ceRNA network represents a promising tool to unravel the complex dialog between redox potential and ovarian signaling pathways involved in reproductive health, aging, and diseases. Full article
(This article belongs to the Special Issue Non-Coding RNAs and Reactive Oxygen Species)
►▼ Show Figures

Figure 1

31 pages, 776 KiB  
Review
Cardiovascular Disease and miRNAs: Possible Oxidative Stress-Regulating Roles of miRNAs
by Seahyoung Lee
Antioxidants 2024, 13(6), 656; https://doi.org/10.3390/antiox13060656 - 27 May 2024
Cited by 1 | Viewed by 1425
Abstract
MicroRNAs (miRNAs) have been highlighted as key players in numerous diseases, and accumulating evidence indicates that pathological expressions of miRNAs contribute to both the development and progression of cardiovascular diseases (CVD), as well. Another important factor affecting the development and progression of CVD [...] Read more.
MicroRNAs (miRNAs) have been highlighted as key players in numerous diseases, and accumulating evidence indicates that pathological expressions of miRNAs contribute to both the development and progression of cardiovascular diseases (CVD), as well. Another important factor affecting the development and progression of CVD is reactive oxygen species (ROS), as well as the oxidative stress they may impose on the cells. Considering miRNAs are involved in virtually every biological process, it is not unreasonable to assume that miRNAs also play critical roles in the regulation of oxidative stress. This narrative review aims to provide mechanistic insights on possible oxidative stress-regulating roles of miRNAs in cardiovascular diseases based on differentially expressed miRNAs reported in various cardiovascular diseases and their empirically validated targets that have been implicated in the regulation of oxidative stress. Full article
(This article belongs to the Special Issue Non-Coding RNAs and Reactive Oxygen Species)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop