Oxidative Stress and Hepatic Inflammation

Dear Colleagues, 

Hepatic inflammation is an important public health problem due to its being a chronic symptom, and liver disease has emerged as one of the leading causes of death and illness worldwide. The global burden of liver disease is poised to swell yet further due to health-modulating factors such as extension of life expectancy, increasingly sedentary lifestyles, and over-nutrition. 

Chronic pathologic processes include viral infection, alcoholic liver disease, non-alcoholic steatohepatitis (NASH), and autoimmune diseases. Depending on the type of underlying liver injury, several mechanisms exist to trigger immune reactions. Chronic immune reactions lead to liver fibrosis. Understanding the mechanisms of inflammation and fibrosis is critically important to developing treatments for chronic liver diseases. 

Over the past few decades, clinical and experimental studies have provided a substantial amount of evidence that oxidative stress, which is defined as an imbalance between oxygen radical production and scavenging, increases in the hepatocyte and at a systemic level during hepatic inflammation. At physiological levels, reactive oxygen species play important roles in intracellular pathways and redox signaling, but at higher levels they may induce cellular dysfunction and damage. Despite extensive investigation, however, the molecular pathways and drug development involved in hepatic-inflammation-associated oxidative stress remain incompletely understood. 

This Special Issue aims to provide a compact overview of the basic mechanisms of, and novel developments in research on, the role of oxidative stress in hepatic inflammation pathophysiology, contributing to a better understanding of the disease. We invite investigators to contribute original research and review articles that will help us to elucidate the effects of oxidative stress on hepatic inflammation. We encourage the submission of studies describing in vitro and in vivo experiments, as well as clinical studies describing the mechanisms, signaling pathways, novel targets, and therapies for hepatic inflammation. 

Dr. Seon-Heui Cha
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• hepatic inflammation
• hepatitis
• non-alcoholic fatty liver disease (NAFLD)
• non-alcoholic steatohepatitis (NASH)
• oxidative stress