The Mechanism of Oxidative Stress Caused by PM2.5
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 7216
Special Issue Editor
Interests: environment and health; diabetes mellitus; obesity; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Numerous epidemiologic studies have demonstrated that short- and long-term exposure to airborne fine particulate matter (PM) with aerodynamic diameter ≤ 2.5 μm (PM2.5) is closely associated with adverse health effects. PM2.5 exposure can induce airway damage, cardiovascular impairments, neurodegenerative disorders, exacerbation of diabetes mellitus and reproductive damage. Although the mechanisms underlying these adverse health effects are not fully understood, PM2.5-induced oxidative stress has been considered as a key mechanism of PM2.5-mediated toxicities. For example, PM2.5 exposure may lead to induction or increased levels of intracellular reactive oxygen species (ROS) and contribute to systemic oxidative stress. PM2.5-induced oxidative stress can activate inflammatory responses. PM2.5 can impair antioxidant defense and decrease the antioxidant capacity of exposed cells. On the other hand, PM2.5-induced ROS may cause toxic effects on cells via reacting to biomacromolecules, such as lipids, proteins, and DNA, impairing their structure and function and ultimately increasing damage to the target cells and tissues.
This Special Issue aims to collect papers dealing with all aspects of the mechanisms by which PM2.5-induced oxidative stress and its constituents act in producing the observed health effects; papers describing intricate signal pathways which are involved in the cellular responses to PM2.5 will be especially welcome.
Prof. Dr. Wenjun Ding
Guest Editor
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Keywords
- PM2.5
- oxidative stress
- toxic effects
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