Oxidative Stress and Male Reproductive Health

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 924

Special Issue Editors


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Guest Editor
School of Environmental and Life Sciences, College of Engineering, Science and Environmental Science, University of Newcastle, Callaghan, NSW 2308, Australia
Interests: oxidative stress; antioxidants; reproductive biology; fertilization; demography
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
GReD Laboratory, Université Clermont Auvergne, CNRS UMR6293, INSERM U1103, Bâtiment CRBC, 28, Place Henri Dunant, 63000 Clermont-Ferrand, France
Interests: oxidative stress and male reproductive impacts; antioxidant therapy in male fertility; oxidative DNA damage

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Guest Editor
Priority Research Centre for Reproductive Science, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW 2308, Australia
Interests: semen; reproductive function; oxidative stress; livestock

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Guest Editor
Priority Research Centre for Reproductive Science, Schools of Biomedical Science & Pharmacy and Environmental & Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia
Interests: male reproduction; spermatozoa; oxidative stress; DNA damage; biochemistry

Special Issue Information

Dear Colleagues,

Oxidative stress is a key factor in the aetiology of male infertility, and is heavily involved in mediating the multiple impacts of age on male reproductive function, including prostatic disease, erectile dysfunction, and the increased incidence of de novo mutations in the offspring of ageing fathers. In vitro, oxidative stress is also known to be involved in impairing the genetic and functional integrity of spermatozoa, and to impact the success of in vitro fertilization. Given the overwhelming importance of oxidative stress as a key determinant of male reproductive health, there should be a role for antioxidant therapy in the treatment of this condition. We still have a great deal to learn in this area, particularly with respect to the particular combinations of antioxidants that should be used in vivo and in vitro, the circumstances under which they should be administered, and what precautions should be taken to avoid reductive stress.

This Special Issue will be a collection of high-quality papers describing the current status of research into oxidative stress and male reproductive health. We invite papers on all aspects of this process, from its biochemical origins to its clinical consequences, particularly if they help point the way to potential therapeutic strategies, including the judicious use of antioxidant therapy. We are also keen to learn from large and small animal models the importance of this process in defining reproductive health and evaluating the potential of antioxidant treatment in vivo and in vitro.

As the Guest Editor, I invite you to contribute to the Special Issue on “Oxidative Stress and Male Reproductive Health”. Original research reports and reviews will be published online in Antioxidants.

Prof. Dr. Robert John Aitken
Prof. Dr. Joel R. Drevet
Dr. Zamira Gibb
Dr. Geoffry De Iuliis
Guest Editors

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Keywords

  • oxidative stress
  • antioxidant therapy
  • male reproductive health
  • male fertility
  • erectile dysfunction
  • prostatic disease
  • male ageing

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Published Papers (1 paper)

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Research

22 pages, 8149 KiB  
Article
Towards the Development of Novel, Point-of-Care Assays for Monitoring Different Forms of Antioxidant Activity: The RoXstaTM System
by Robert J. Aitken, Alexandra Wilkins, Natasha Harrison, Kimia Kobarfard and Sarah Lambourne
Antioxidants 2024, 13(11), 1379; https://doi.org/10.3390/antiox13111379 - 11 Nov 2024
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Abstract
(1) Background: This study set out to develop a series of simple, novel, rapid methods for assessing different forms of antioxidant activity. (2) Methods: An ABTS platform was used to engineer: (i) an electrochemical post-activation assay to assess free radical scavenging activity; (ii) [...] Read more.
(1) Background: This study set out to develop a series of simple, novel, rapid methods for assessing different forms of antioxidant activity. (2) Methods: An ABTS platform was used to engineer: (i) an electrochemical post-activation assay to assess free radical scavenging activity; (ii) an electrochemical pre-activation strategy to assesses the suppression of free radical formation; (iii) a horseradish peroxidase-mediated oxidation system to monitor hydrogen peroxide scavenging activity and (iv) a cumene peroxide-hematin system to determine the ability of samples to scavenge the mixture of organic peroxides and peroxyl and alkoxyl radicals generated in the presence of these reagents. Each assay was assessed against a panel of candidate antioxidant compounds to determine their relative activities and specificities. In addition, human semen samples were analyzed to determine how the results of these antioxidant assays correlated with semen quality. (3) Results: All 4 assays revealed dose-dependent antioxidant activity on the part of vitamin C, N-acetyl cysteine, hypotaurine, BSA, melatonin, glutathione, resveratrol and epigallocatechin gallate. The other compounds tested either completely lacked antioxidant activity or were only active in one of the assays. Using unfractionated human semen as an exemplar of biological fluids rich in antioxidants, the outputs from the individual assays were found to reflect different aspects of semen quality. When the data from all 4 assays were combined, accurate predictions were generated reflecting the importance of oxidative stress in defining semen quality as reflected by sperm count, seminal lipid aldehyde content, sperm DNA damage and free radical generation by the sperm mitochondria. (4) Conclusions: The methodologies described in this paper constitute the basis for rapid, point-of-care assessments of oxidative stress. Full article
(This article belongs to the Special Issue Oxidative Stress and Male Reproductive Health)
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