Antioxidant Capacity of Natural Compounds from Vegetable Matrices

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 895

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Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy
Interests: food; chemicals; sustainability; synthesis; peptides
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Dear Colleagues,

Antioxidants are molecules that act against free radicals in our body, which are compounds that can cause harm if their levels become too high. They are linked to multiple illnesses, including diabetes, heart disease, and cancer. Our body possesses a rich arsenal of antioxidant defenses to keep free radicals in check; however, in some situations, this is not enough. Thus, antioxidants can be found in fruits, vegetables and other plant-based foods. Several vitamins, such as vitamin E and C, are effective antioxidants. Antioxidant preservatives also play a crucial role in food production by increasing shelf life. Dietary intake of antioxidants is essential for optimal health, but an excessive intake of isolated antioxidants can have toxic effects and may even promote rather than prevent oxidative damage, a phenomenon termed the “antioxidant paradox”. Eating plenty of antioxidant-rich vegetables is preferential, as studies indicate that they reduce oxidative damage to a greater extent than supplements; thus, vegetable and fruit compounds work synergistically. The best strategy to ensure adequate antioxidant intake is to follow a diet rich in various vegetables and fruits, alongside other healthy habits. We will welcome and consider for publication in this journal any type of contribution, both research articles and reviews, based on this topic and all aspects related to it.

Dr. Azzurra Stefanucci
Guest Editor

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Keywords

  • antioxidants
  • plants
  • vegetable
  • health
  • protein
  • phytochemicals

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Published Papers (1 paper)

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Research

23 pages, 6533 KiB  
Article
Inhibition of Accumulation of Neutral Lipids and Their Hydroperoxide Species in Hepatocytes by Bioactive Allium sativum Extract
by Dya Fita Dibwe, Saki Oba, Satomi Monde and Shu-Ping Hui
Antioxidants 2024, 13(11), 1310; https://doi.org/10.3390/antiox13111310 - 28 Oct 2024
Viewed by 544
Abstract
Our ongoing research suggests that extracts from plant-based foods inhibit the accumulation of lipid droplets (LDs) and oxidized lipid droplets (oxLDs) in liver cells. These findings suggest their potential use in the alleviation of metabolic dysfunction-associated fatty liver disease (MAFLD) and its most [...] Read more.
Our ongoing research suggests that extracts from plant-based foods inhibit the accumulation of lipid droplets (LDs) and oxidized lipid droplets (oxLDs) in liver cells. These findings suggest their potential use in the alleviation of metabolic dysfunction-associated fatty liver disease (MAFLD) and its most severe manifestation, metabolic dysfunction-associated steatohepatitis (MASH). Allium extracts (ALs: AL1–AL9) were used to assess their ability to reduce lipid droplet accumulation (LDA) and oxidized lipid droplet accumulation (oxLDA) by inhibiting neutral lipid accumulation and oxidation in LD. Among the tested Allium extracts, AL1, AL3, and AL6 demonstrated substantial inhibitory effects on the LDA. Furthermore, AL1 extract showed real-time inhibition of LDA in HepG2 cells in DMEM supplemented with oleic acid (OA) within 12 h of treatment. Our lipidomic approach was used to quantify the accumulation and inhibition of intracellular triacylglycerol (TAG) and oxidized TAG hydroperoxide [TG (OOH) n = 3] species in hepatocytes under OA and linoleic acid loading conditions. These results suggest that Allium-based foods inhibit LD accumulation by decreasing intracellular lipids and lipid hydroperoxides in the hepatocytes. The metabolomic analysis of AL1—the bioactive LDAI extract—using both LC-MS/MS and 1D-NMR [1H, 13C, and Dept (135 and 90)] approaches revealed that AL1 contains mainly carbohydrates and glucoside metabolites, including iridoid glucosides, as well as minor amino acids, organosulfur compounds, and organic acids such as the antioxidant ascorbic acid (KA2 = S13), and their derivatives, suggesting that AL1 could be a potential resource for the development of functional foods and in drug discovery targeting MAFLD/MASH and other related diseases. Full article
(This article belongs to the Special Issue Antioxidant Capacity of Natural Compounds from Vegetable Matrices)
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