The Role of Natural Antioxidants in Fruits and Vegetables in Human Health

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1124

Special Issue Editor


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Guest Editor
Institute of Sciences of Food Production, National Research Council, 07100 Sassari, Italy
Interests: biodiversity; biosensors; essential oils sensors cell and molecular biology
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Special Issue Information

Dear Colleagues,

Fruits and vegetables are well known for their rich contents of natural antioxidants, which play a crucial role in health promotion by neutralizing free radicals and reducing oxidative stress. This Special Issue focuses on exploring the antioxidant potential of natural bioactive compounds specifically derived from fruits and vegetables, with an emphasis on their ability to combat oxidative stress and inflammation—two key drivers of chronic diseases such as cancer, cardiovascular disease, and neurodegenerative disorders.

We request cutting-edge research that investigates the molecular mechanisms, bioavailability, and therapeutic applications of natural antioxidants derived from fruits and vegetables. Topics of interest include the identification of novel antioxidant compounds, mechanisms of action, and their preventive and therapeutic potential. Studies encompassing a wide range of methodologies, such as in vitro and in vivo models, as well as clinical trials, are welcome. This Special Issue will highlight how natural antioxidants from fruits and vegetables can be harnessed to support human health and combat chronic disease.

Key areas of interest include, but are not limited to, the following:

  • Novel natural antioxidant compounds from fruits and vegetables;
  • Mechanisms of action in oxidative stress and inflammation mitigation;
  • Synergistic effects of multiple bioactive compounds;
  • Bioavailability and metabolism of fruit and vegetable antioxidants;
  • Preclinical and clinical evidence of antioxidant efficacy;
  • Role of natural antioxidants from fruits and vegetables in disease prevention and therapy.

Dr. Antonio Barberis
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • anti-inflammation
  • oxidative stress
  • fruits
  • vegetables
  • oxidation reactions
  • functional foods

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Published Papers (2 papers)

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Research

25 pages, 1261 KiB  
Article
Energy Intake-Dependent Genetic Associations with Obesity Risk: BDNF Val66Met Polymorphism and Interactions with Dietary Bioactive Compounds
by Ting Zhang and Sunmin Park
Antioxidants 2025, 14(2), 170; https://doi.org/10.3390/antiox14020170 - 30 Jan 2025
Viewed by 359
Abstract
Obesity represents a complex interplay between genetics, nutrition, and lifestyle. This study aimed to elucidate the intricate relationship between genetic variants, energy intake, and bioactive compounds in influencing obesity risk, particularly in low energy intake, to reveal how dietary intake modulates molecular-level interactions. [...] Read more.
Obesity represents a complex interplay between genetics, nutrition, and lifestyle. This study aimed to elucidate the intricate relationship between genetic variants, energy intake, and bioactive compounds in influencing obesity risk, particularly in low energy intake, to reveal how dietary intake modulates molecular-level interactions. We analyzed 53,117 participants stratified by obesity status and energy intake levels. Genome-wide association studies explored the genetic variants associated with obesity risk in low-energy- and high-energy-intake subgroups. Advanced computational approaches, including molecular docking, k-means clustering, and uniform manifold approximation and projection (UMAP), were employed to analyze interactions between missense variants and natural compounds. Ten genetic variants were significantly associated with obesity, particularly in participants with low energy intake. The most prominent variants included brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265). Molecular docking identified 152 bioactive compounds with strong binding affinity to BDNF Val66Met, including 107 compounds binding to both wild and mutant types. Citrus fruits and green vegetables showed selective binding to the mutant type. Antioxidant nutrient intake (anthocyanins, isoflavonoids, vitamins C and E, selenium) was higher in lean versus obese individuals in the high-energy-intake group. Alcohol consumption and selenium intake modulated polygenic risk scores’ influence on obesity risk in high-energy-intake individuals. Notably, citrus fruit intake correlated with lower BMI across all BDNF rs6265 genotypes. In conclusion, energy intake-specific genetic associations with obesity and identifies potential bioactive compounds for targeted interventions. The findings suggest that antioxidant nutrient intake, particularly from citrus fruits, may help manage obesity risk, especially in individuals with specific genetic variants. Full article
25 pages, 3762 KiB  
Article
Naringin vs. Citrus x paradisi L. Peel Extract: An In Vivo Journey into Oxidative Stress Modulation
by  Jolita Stabrauskiene, Ilona Sadauskiene, Arunas Liekis, Zoja Mikniene and Jurga Bernatoniene
Antioxidants 2025, 14(2), 157; https://doi.org/10.3390/antiox14020157 - 28 Jan 2025
Viewed by 388
Abstract
Citrus fruits, mainly grapefruit (Citrus x Paradisi L.), are rich in bioactive compounds with potential antioxidant properties. This study investigated the antioxidant effects of naringin (NR) and ethanolic Citrus x paradisi L peel (E) in reducing aluminum chloride (AlCl3)-induced oxidative [...] Read more.
Citrus fruits, mainly grapefruit (Citrus x Paradisi L.), are rich in bioactive compounds with potential antioxidant properties. This study investigated the antioxidant effects of naringin (NR) and ethanolic Citrus x paradisi L peel (E) in reducing aluminum chloride (AlCl3)-induced oxidative stress in mice. Quantitative analysis using HPLC identified optimal extraction conditions, combination ultrasound and reflux extraction (UH50), resulting in high concentrations of naringin (49.13 mg/g) and naringenin (63.99 µg/g). Mice were treated with NR and E to evaluate their effects on key markers of oxidative stress: reduced glutathione (GSH), malondialdehyde (MDA), and catalase (CAT). The E effectively reduced MDA levels in blood, brain, and liver tissues, with a more substantial effect on controlling lipid peroxidation. In contrast, NR was more effective in restoring GSH levels and CAT activity, suggesting a broader enhancement of antioxidant defense. These findings provide information about specific mechanisms of NR and E and their therapeutic potential in managing oxidative stress and developing products with synergistic efficacy. Full article
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