Interactions between Dietary Flavonoids and Gut Microbiota: Functional Outcomes
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (31 December 2014) | Viewed by 26654
Special Issue Editors
Interests: dietary antioxidants; chronic disease prevention
Special Issues, Collections and Topics in MDPI journals
2. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA
Interests: antioxidants; oxidative stress; polyphenols; flavonoids; glucoregulation; inflammation; tree nuts; berries; whole grains
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues.
Flavonoids are secondary plant metabolites and are ubiquitous in plant foods. After consumption, flavonoids influence numerous metabolic and signaling pathways involved in the initiation and/or progression of chronic diseases. The human gut is densely populated with commensal and symbiotic microbiota, with the majority of the constituent microbes being bacteria. Gut microbiota have been implicated in developmental, immunological, and nutritional function of the host and, thus, appear to have a profound impact on human health beyond the fermentation of non-digestible food compounds. The microbiota composition of healthy people differs from that of patients with obesity, diabetes mellitus, and other chronic diseases. Ingested flavonoids are mostly transferred to the lower gut where they are subject to gut microbiota-mediated metabolism. Elucidating the metabolic fate of dietary flavonoids in the lower gut and related interactions between flavonoids and microbiota will contribute to our understanding of their impact on human health and the application of this knowledge to revising dietary guidelines and developing novel functional foods. The aim of this special issue is to cover and expand upon the following issues:
- Interactions between flavonoids and gut microbiota and their impact on health; in particular through research approaches employing high-throughput metagenomic, metatranscriptomic, and metabolomic methods
- The use and strengths, and limitations of various experimental approaches, including in vitro gut models, human microbiota-associated animal studies, and human intervention trials in helping to unravel the mechanisms and consequences of interactions between flavonoids and gut microbiota
- To elucidate the impact of individual genetic, inflammatory, pathophysiological, and/or dietary factors on the interaction between flavonoids and gut microbiota
Prof. Dr. Jeffrey B. Blumberg
Dr. C.-Y. Oliver Chen
Guest Editors
Manuscript Submission Information
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Keywords
- flavonoids
- gut microbiota
- metagenomic
- metabolomic
- chronic disease
- inflammation
- antioxidation
- intestinal integrity
- immunity
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