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Antioxidants
Special Issues
Lipid Peroxidation: Analysis and Applications in Biological Systems
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Lipid Peroxidation: Analysis and Applications in Biological Systems

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Aberrant Oxidation of Biomolecules".

Deadline for manuscript submissions: closed (30 September 2018) | Viewed by 28692

Special Issue Editors

Dr. Jetty Chung-Yung Lee

E-Mail Website
Guest Editor
School of Biological Sciences, The University of Hong Kong, Hong Kong, China
Interests: lipid oxidation biomarkers; antioxidant and oxidative stress in human nutrition; short chain fatty acid; fatty acid metabolites; targeted lipidomics
Special Issues, Collections and Topics in MDPI journals
Dr. Thierry Durand

E-Mail Website
Guest Editor
Directeur de Recherche CNRSInstitut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, Université de Montpellier, ENSCM, France
Interests: Total synthesis of bioactive lipids (iso-, phyto- and neuroprostanes, iso-, phyto and neurofurans, lipophenols, protectins, FAHFA); Quantification of isoprostanoids in biological fluids and vegetable matrixs, using LC-MS; Oxidative stress and disease development

Special Issue Information

Dear Colleagues,

It is globally known the interaction of free radical/reactive oxygen species (ROS) in lipid metabolism, namely polyunsaturated fatty acids are the core source of lipid peroxidation reaction in the biological systems. The metabolites released can be biomarkers of oxidative stress such as isoprostanes in mammals and phytoprostanes in plants and food or act as mediators in signalling pathways to redox responses, and even displayed some health benefits. Collectively, they are also known as oxylipins and are ubiquitous in the living system. In retrospect, antioxidants have been known for decades to regulate the release of these metabolites and prevent progression of diseases, and recently, phytochemicals tandem fatty acids including lipophenols showed potent antioxidant properties. However, proper selection of analysis for valid evaluation of antioxidant potential in desired applications is needed to understand the principle mechanisms of these oxylipins including synthesis, distribution, metabolism, and excretion in plants and mammals.

This Special Issue will publish original research papers and reviews on aspects of oxylipins derived from polyunsaturated fatty acids related to the following topics: health and diseases, metabolism, antioxidants, analytical views, chemistry and biomarkers.

  • Oxylipins
  • Isoprostanes
  • Phytoprostanes
  • Polyunsaturated fatty acids
  • Lipophenols 
  • Mass spectrometry

Dr. Jetty Chung-Yung Lee
Dr. Thierry Durand
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (6 papers)

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Editorial

Jump to: Research, Review

2 pages, 158 KiB  
Editorial
Lipid Peroxidation: Analysis and Applications in Biological Systems
by Jetty Chung-Yung Lee and Thierry Durand
Antioxidants 2019, 8(2), 40; https://doi.org/10.3390/antiox8020040 - 13 Feb 2019
Cited by 7 | Viewed by 2574
Abstract
Lipid peroxidation is an ambiguous event in all biological species [...] Full article
(This article belongs to the Special Issue Lipid Peroxidation: Analysis and Applications in Biological Systems)

Research

Jump to: Editorial, Review

18 pages, 2067 KiB  
Article
New Lipophenol Antioxidants Reduce Oxidative Damage in Retina Pigment Epithelial Cells
by Espérance Moine, Philippe Brabet, Laurent Guillou, Thierry Durand, Joseph Vercauteren and Céline Crauste
Antioxidants 2018, 7(12), 197; https://doi.org/10.3390/antiox7120197 - 19 Dec 2018
Cited by 30 | Viewed by 5102
Abstract
Age-related macular degeneration (AMD) is a multifactorial pathology and its progression is exacerbated by oxidative stress. Oxidation and photo-oxidation reactions modify lipids in retinal cells, contribute to tissue injury, and lead to the formation of toxic adducts. In particular, autofluorescent pigments such as [...] Read more.
Age-related macular degeneration (AMD) is a multifactorial pathology and its progression is exacerbated by oxidative stress. Oxidation and photo-oxidation reactions modify lipids in retinal cells, contribute to tissue injury, and lead to the formation of toxic adducts. In particular, autofluorescent pigments such as N-retinylidene-N-retinylethanolamine (A2E) accumulate as lipofuscin in retinal pigment epithelial cells, contribute to the production of additional reactive oxygen species (ROS), and lead to cell degeneration. In an effort to develop efficient antioxidants to reduce damage caused by lipid oxidation, various natural polyphenols were structurally modified to increase their lipophilicity (lipophenols). In this study, resveratrol, phloroglucinol, quercetin and catechin were selected and conjugated to various polyunsaturated fatty acids (PUFAs) using classical chemical strategies or enzymatic reactions. After screening for cytotoxicity, the capacity of the synthesized lipophenols to reduce ROS production was evaluated in ARPE-19 cells subjected to H2O2 treatment using a dichlorofluorescein diacetate probe. The positions of the PUFA on the polyphenol core appear to influence the antioxidant effect. In addition, two lipophenolic quercetin derivatives were evaluated to highlight their potency in protecting ARPE-19 cells against A2E photo-oxidation toxicity. Quercetin conjugated to linoleic or α-linolenic acid were promising lipophilic antioxidants, as they protected ARPE-19 cells from A2E-induced cell death more effectively than the parent polyphenol, quercetin. Full article
(This article belongs to the Special Issue Lipid Peroxidation: Analysis and Applications in Biological Systems)
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13 pages, 2386 KiB  
Article
Profiling of Omega-Polyunsaturated Fatty Acids and Their Oxidized Products in Salmon after Different Cooking Methods
by Kin Sum Leung, Jean-Marie Galano, Thierry Durand and Jetty Chung-Yung Lee
Antioxidants 2018, 7(8), 96; https://doi.org/10.3390/antiox7080096 - 24 Jul 2018
Cited by 44 | Viewed by 6012
Abstract
Consumption of food containing n-3 PUFAs, namely EPA and DHA, are known to benefit health and protect against chronic diseases. Both are richly found in marine-based food such as fatty fish and seafood that are commonly cooked prior to consumption. However, the elevated [...] Read more.
Consumption of food containing n-3 PUFAs, namely EPA and DHA, are known to benefit health and protect against chronic diseases. Both are richly found in marine-based food such as fatty fish and seafood that are commonly cooked prior to consumption. However, the elevated temperature during cooking potentially degrades the EPA and DHA through oxidation. To understand the changes during different cooking methods, lipid profiles of raw, boiled, pan-fried and baked salmon were determined by LC-MS/MS. Our results showed that pan-frying and baking elevated the concentration of peroxides in salmon, whereas only pan-frying increased the MDA concentration, indicating it to be the most severe procedure to cause oxidation among the cooking methods. Pan-frying augmented oxidized products of n-3 and n-6 PUFAs, while only those of n-3 PUFA were elevated in baked salmon. Notably, pan-frying and baking increased bioactive oxidized n-3 PUFA products, in particular F-4t-neuroprostanes derived from DHA. The results of this study provided a new insight into the application of heat and its effect on PUFAs and the release of its oxidized products in salmon. Full article
(This article belongs to the Special Issue Lipid Peroxidation: Analysis and Applications in Biological Systems)
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Review

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13 pages, 826 KiB  
Review
Oxidative Stress in the Newborn Period: Useful Biomarkers in the Clinical Setting
by Iván Millán, José David Piñero-Ramos, Inmaculada Lara, Anna Parra-Llorca, Isabel Torres-Cuevas and Máximo Vento
Antioxidants 2018, 7(12), 193; https://doi.org/10.3390/antiox7120193 - 14 Dec 2018
Cited by 40 | Viewed by 6084
Abstract
Aerobic metabolism is highly efficient in providing energy for multicellular organisms. However, even under physiological conditions, an incomplete reduction of oxygen produces reactive oxygen species and, subsequently, oxidative stress. Some of these chemical species are highly reactive free radicals capable of causing functional [...] Read more.
Aerobic metabolism is highly efficient in providing energy for multicellular organisms. However, even under physiological conditions, an incomplete reduction of oxygen produces reactive oxygen species and, subsequently, oxidative stress. Some of these chemical species are highly reactive free radicals capable of causing functional and structural damage to cell components (protein, lipids, or nucleotides). Oxygen is the most used drug in ill-adapted patients during the newborn period. The use of oxygen may cause oxidative stress-related diseases that increase mortality and cause morbidity with adverse long-term outcomes. Conditions such as prematurity or birth asphyxia are frequently treated with oxygen supplementation. Both pathophysiological situations of hypoxia–reoxygenation in asphyxia and hyperoxia in premature infants cause a burst of reactive oxygen species and oxidative stress. Recently developed analytical assays using mass spectrometry have allowed us to determine highly specific biomarkers with minimal samples. The detection of these metabolites will help improve the diagnosis, evolution, and response to therapy in oxidative stress-related conditions during the newborn period. Full article
(This article belongs to the Special Issue Lipid Peroxidation: Analysis and Applications in Biological Systems)
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19 pages, 1106 KiB  
Review
Structural/Functional Matches and Divergences of Phytoprostanes and Phytofurans with Bioactive Human Oxylipins
by Sonia Medina, Ángel Gil-Izquierdo, Thierry Durand, Federico Ferreres and Raúl Domínguez-Perles
Antioxidants 2018, 7(11), 165; https://doi.org/10.3390/antiox7110165 - 16 Nov 2018
Cited by 29 | Viewed by 4180
Abstract
Structure-activity relationship (SAR) constitutes a crucial topic to discover new bioactive molecules. This approach initiates with the comparison of a target candidate with a molecule or a collection of molecules and their attributed biological functions to shed some light in the details of [...] Read more.
Structure-activity relationship (SAR) constitutes a crucial topic to discover new bioactive molecules. This approach initiates with the comparison of a target candidate with a molecule or a collection of molecules and their attributed biological functions to shed some light in the details of one or more SARs and subsequently using that information to outline valuable application of the newly identified compounds. Thus, while the empiric knowledge of medicinal chemistry is critical to these tasks, the results retrieved upon dedicated experimental demonstration retrieved resorting to modern high throughput analytical approaches and techniques allow to overwhelm the constraints adduced so far to the successful accomplishment of such tasks. Therefore, the present work reviews critically the evidences reported to date on the occurrence of phytoprostanes and phytofurans in plant foods, and the information available on their bioavailability and biological activity, shedding some light on the expectation waken up due to their structural similarities with prostanoids and isoprostanes. Full article
(This article belongs to the Special Issue Lipid Peroxidation: Analysis and Applications in Biological Systems)
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13 pages, 1252 KiB  
Review
Isoprostanoids in Clinical and Experimental Neurological Disease Models
by Cinzia Signorini, Claudio De Felice, Jean-Marie Galano, Camille Oger, Silvia Leoncini, Alessio Cortelazzo, Lucia Ciccoli, Thierry Durand, Joussef Hayek and Jetty Chung-Yung Lee
Antioxidants 2018, 7(7), 88; https://doi.org/10.3390/antiox7070088 - 11 Jul 2018
Cited by 19 | Viewed by 3988
Abstract
Isoprostanoids are a large family of compounds derived from non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs). Unlike other oxidative stress biomarkers, they provide unique information on the precursor of the targeted PUFA. Although they were discovered about a quarter of century ago, the [...] Read more.
Isoprostanoids are a large family of compounds derived from non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs). Unlike other oxidative stress biomarkers, they provide unique information on the precursor of the targeted PUFA. Although they were discovered about a quarter of century ago, the knowledge on the role of key isoprostanoids in the pathogenesis of experimental and human disease models remains limited. This is mainly due to the limited availability of highly purified molecules to be used as a reference standard in the identification of biological samples. The accurate knowledge on their biological relevance is the critical step that could be translated from some mere technical/industrial advances into a reliable biological disease marker which is helpful in deciphering the oxidative stress puzzle related to neurological disorders. Recent research indicates the value of isoprostanoids in predicting the clinical presentation and evolution of the neurological diseases. This review focuses on the relevance of isoprostanoids as mediators and potential biomarkers in neurological diseases, a heterogeneous family ranging from rare brain diseases to major health conditions that could have worldwide socioeconomic impact in the health sector. The current challenge is to identify the preferential biochemical pathways that actually follow the oxidative reactions in the neurological diseases and the consequence of the specific isoprostanes in the underlying pathogenic mechanisms. Full article
(This article belongs to the Special Issue Lipid Peroxidation: Analysis and Applications in Biological Systems)
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