Redox Metals and Catecholamines in Neurodegenerative Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 10 January 2025 | Viewed by 1205
Special Issue Editors
Interests: redox chemistry; neurodegenerative diseases; neurodegeneration
Interests: metal complexes; coordination chemistry; catalysis; neurodegeneration
Special Issue Information
Dear Colleagues,
Alteration in metal levels is detected in different pathophysiological mechanisms associated with neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and multiple sclerosis (MS). The imbalance of some essential metals, including zinc (Zn), copper (Cu), iron (Fe) and manganese (Mn), compromises structures and functions of several proteins and enzymes, promoting neurotoxicity, mitochondrial dysregulation and cell death. Another pathological mechanism usually reviewed as pivotal in neurodegeneration involves catecholamine oxidation-derived neurodamage. Catecholamines such as dopamine, epinephrine and norepinephrine are reactive molecules prone to undergo dioxygen-dependent self-oxidation and metal-catalyzed oxidation. These oxidative pathways can give rise to unspecific protein modifications, resulting in structural misfolding, inactivation and aggregation into insoluble neuro-deposits.
This Special Issue aims to provide the basis for a better understanding of the metals and catecholamine-related biochemical mechanisms that trigger these neurodisorders. We invite investigators to submit original papers focused on the topics outlined below:
- Catecholamine reactivity and interplay with redox active metals
- Catecholamine oxidative products and metals as neuronal biomarkers
- Catecholamine-mediated modification of proteins and peptides
- Neuroinflammation promoted by trace metals
- Recent advances in drug discovery based on metal and catecholamine-related pathways.
Prof. Dr. Enrico Monzani
Dr. Chiara Bacchella
Guest Editors
Manuscript Submission Information
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Keywords
- neurodegeneration
- catecholamines
- redox metals
- oxidative stress
- protein modification
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