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Antioxidants in Natural Plant Products: From Biological Activities to Applied Efficiency Evaluation

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 3516

Special Issue Editors


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Guest Editor
Independent Researcher, Valencia, Spain
Interests: plant-soil interactions; fertilisers; biostimulants; physiological and molecular responses; abiotic stress; plant production

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Guest Editor
UMR AGAP Institut, University of Montpellier, CIRAD, INRAE, Institut Agro, F-34398 Montpellier, France
Interests: citrus; plant adaptation to stress; HLB; polyploidy

Special Issue Information

Dear Colleagues,

Antioxidants are becoming increasingly important in the diet because of their many health benefits. Plants are a natural source of antioxidants, and the use of medicinal plants to maintain human health is of vital interest. The synthesis of antioxidants as a natural source of plant metabolism serves as a means of defence against biotic and abiotic agents in the environment. Environmental stressors, such as pollutants, nutrient deficiencies, water availability (drought/irrigation), temperatures, light intensity, photoperiod, radiation, etc., can increase the levels of reactive oxygen species (ROS); these lead to an imbalance in their production and scavenging, causing oxidative stress. As a defence mechanism, plants activate enzymatic and non-enzymatic systems in their metabolism to prevent damage to proteins, membranes and DNA. Reduced glutathione, vitamins (vitamins E and C), carotenoids (xanthophylls and carotenes) and polyphenols (such as phenolic compounds, particularly the flavonoid subclass, anthocyanins, lignans and stilbenes) are examples of antioxidant compounds produced by plants to scavenge ROS. Some of the most important antioxidant enzymes are glutathione, ascorbate peroxidase, superoxide dismutase and catalase. These antioxidants not only help plants adapt to environmental changes but also protect the human body against oxidative stress and related diseases, such as Alzheimer's, neurological disorders, ageing, cancer and diabetes. Plants produce more antioxidants to help them withstand environmental stress, and the quantity and quality of these antioxidants are determined by intrinsic plant characteristics and external influences. Therefore, it is crucial to increase our knowledge of natural products that increase the production capacity of plant secondary metabolites, as well as their phytoantioxidant potential, as a means to improve crop protection and production and human health due to their pharmacological and nutraceutical power.

Authors are therefore invited to submit original research articles, review articles and clinical case reports on antioxidants from plants. Antioxidant evaluation and the mechanisms of action may be addressed in silico, in vitro and/or in vivo. However, in cases where the source of antioxidants is unknown, it is essential to characterise their constituents using chemical analysis techniques.

Dr. Ricardo Gil-Ortiz
Dr. Raphaël Morillon
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants in plants
  • natural products
  • biostimulants
  • medicinal plants
  • capacity and response to antioxidants
  • antioxidant analysis
  • quality indicators
  • nutraceutical and pharmacological use
  • antioxidant metabolic reactions

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Published Papers (2 papers)

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Research

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19 pages, 1506 KiB  
Article
The Optimisation of Ultrasound-Assisted Extraction for the Polyphenols Content and Antioxidant Activity on Sanguisorba officinalis L. Aerial Parts Using Response Surface Methodology
by Anna Muzykiewicz-Szymańska, Edyta Kucharska, Robert Pełech, Anna Nowak, Karolina Jakubczyk and Łukasz Kucharski
Appl. Sci. 2024, 14(20), 9579; https://doi.org/10.3390/app14209579 - 21 Oct 2024
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Abstract
The aim of this study was to optimise ultrasound-assisted extraction (UAE) of the herb Sanguisorba officinalis L. in terms of the antioxidant activity (DPPH and FRAP method) and total polyphenol content (TPC). Optimisation was performed using the response surface methodology (RSM) with a [...] Read more.
The aim of this study was to optimise ultrasound-assisted extraction (UAE) of the herb Sanguisorba officinalis L. in terms of the antioxidant activity (DPPH and FRAP method) and total polyphenol content (TPC). Optimisation was performed using the response surface methodology (RSM) with a third-degree (33) Central Composite Design (CCD) approach. The RSM was applied to obtain the optimal combination of (1) raw material content (2.25–7.5 g raw material/100 mL of solvent), (2) ethanol concentration (20–60% v/v), and (3) extraction time (1–15 min). The optimal conditions for the extraction of polyphenols and antioxidant potential were a raw material content of 7.5 g/100 mL of solvent (solid/solvent ratio 13.3 mL/g), an ethanol concentration of 47% v/v, and an extraction time of 10 min. At these optimal extraction parameters, the maximum extraction of polyphenols and antioxidant activity obtained experimentally was found to be very close to its predicted value and was 12.9 mmol Trolox/L (DPPH method), 19.4 mmol FeSO4/L (FRAP method), and 2.1 g GA/L (TPC). The mathematical model developed was found to fit with the experimental data on the antioxidant potential and polyphenol extraction. The n-octanol/water partition coefficient of the optimised extract was used to determine their lipophilicity. Our studies have shown that the optimised extract is highly hydrophilic (log P < 0). Optimal parameters can be used for the industrial extraction of the S. officinalis herb for the needs of, among others, the pharmaceutical or cosmetic industry. Full article
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Review

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18 pages, 1292 KiB  
Review
Potential of Plant Stem Cells as Helpful Agents for Skin Disorders—A Narrative Review
by Anastasia Aliesa Hermosaningtyas, Justyna Chanaj-Kaczmarek, Małgorzata Kikowska, Justyna Gornowicz-Porowska, Anna Budzianowska and Mariola Pawlaczyk
Appl. Sci. 2024, 14(16), 7402; https://doi.org/10.3390/app14167402 - 22 Aug 2024
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Abstract
Recently, cellular senescence has been of great interest due to its pleiotropic nature and association with both physiological (e.g., aging) and pathological conditions. Excessive accumulation of reactive oxygen species (ROS) can induce inflammation, which accelerates skin aging (also premature aging) and may cause [...] Read more.
Recently, cellular senescence has been of great interest due to its pleiotropic nature and association with both physiological (e.g., aging) and pathological conditions. Excessive accumulation of reactive oxygen species (ROS) can induce inflammation, which accelerates skin aging (also premature aging) and may cause several dermatoses. It has been postulated that plant-derived antioxidants, especially plant stem cells, may prevent cell damage by preserving stemness and reducing cellular senescence by ROS targeting. Therefore, this paper aims to review and summarize recent developments and innovative techniques associated with plant-derived stem cells in relation to skin senescence. This review also presents the possible pathways involved in this process. Particular attention was paid to the potential applications of plant stem cells as senostatics/senomorphics produced by modern plant biotechnology methods. Furthermore, the advantages, limitations, and future directions of this technology are also discussed. This knowledge allows the development of personalized strategies to create a healthy balance in skin care. Plant stem cells could be a more feasible and practical approach to combating the adverse effects of skin senescence processes. Full article
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