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Applied Sciences
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Polymer Scaffolds for Tissue Engineering Applications
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Polymer Scaffolds for Tissue Engineering Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: closed (20 July 2022) | Viewed by 7061

Special Issue Editors

Dr. Katarzyna Klimek

E-Mail Website1 Website2
Guest Editor
Chair and Department of Biochemistry and Biotechnology, Medical University of Lublin, Chodzki 1 Street, 20-059 Lublin, Poland
Interests: cell culture; cell–biomaterial interactions; biocompatibility; hydrogels; polymers; tissue engineering; regenerative medicine; scaffolds
Special Issues, Collections and Topics in MDPI journals
Dr. Timothy E. L. Douglas

E-Mail Website
Guest Editor
Engineering Department, Lancaster University, Gillow Avenue, Lancaster LA1 4YW, UK
Interests: hydrogels; implant coatings; composites; biopolymers; languages in science
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tissue engineering is a multidisciplinary field, allowing for the supply of appropriate and alternative solutions for autografts, allografts, as well as xenografts. One tissue engineering approach includes the use of natural polymers and synthetic ones. Polymer-based scaffolds are utilized for the repair and regeneration of many organs, such as skin, liver, pancreas, cartilage, or bone.

The main aim of this Special Issue is to underline the recent progress in the field of tissue engineering, with particular emphasis on polymer scaffolds. All articles (original research papers and reviews) are welcome in this Special Issue. Submitted manuscripts should be primarily (but not only) concerned with the development of new wound dressings, skin substitutes, bone scaffolds, cartilage scaffolds, as well as drug carriers. Papers presenting a complex description (involving inter alia fabrication methods and biological, mechanical, and physicochemical characterization) of novel polymer-based biomaterials for tissue engineering applications are mainly promoted.

Dr. Katarzyna Klimek
Dr. Timothy E.L. Douglas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Composites
  • Skin dressings
  • Hydrogels
  • Bone and cartilage scaffolds
  • Natural and synthetic polymers
  • Tissue engineering
  • Drug carriers

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Published Papers (2 papers)

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Research

13 pages, 3711 KiB  
Article
Studying the Effect of Chondroitin Sulfate on the Physicochemical Properties of Novel Gelatin/Chitosan Biopolymer-Based Cryogels
by Gulshakhar Kudaibergen, Madina Zhunussova, Ellina A. Mun, Anar Arinova and Vyacheslav Ogay
Appl. Sci. 2021, 11(21), 10056; https://doi.org/10.3390/app112110056 - 27 Oct 2021
Cited by 5 | Viewed by 2480
Abstract
The application of biopolymers in tissue engineering is of a great interest due to of their inherent properties such as cell adhesion, biodegradation, bioavailability, and viscoelasticity. In this study, we synthesized cryogels based on biopolymers of gelatin, chitosan, and chondroitin sulfate by cryopolymerization [...] Read more.
The application of biopolymers in tissue engineering is of a great interest due to of their inherent properties such as cell adhesion, biodegradation, bioavailability, and viscoelasticity. In this study, we synthesized cryogels based on biopolymers of gelatin, chitosan, and chondroitin sulfate by cryopolymerization and studied the effect of chondroitin sulfate on changing the physicochemical properties of cryogels such as pore size, pore volume, density, gel fraction, and biodegradation. A macroporous surface of the synthesized polymers has been investigated by SEM. The glass transition temperatures of the crosslinked cryogels, determined by the DSC method, were higher compared to that of the non-crosslinked cryogel used as a reference. The results of the MTT test showed that aqueous extracts of the prepared cryogels had no toxic effect on rat adipose-derived mesenchymal stem cells. The research in this area is of great importance and provides new insights into novel, effective methods for obtaining biopolymers that can be used as carriers of cells. Full article
(This article belongs to the Special Issue Polymer Scaffolds for Tissue Engineering Applications)
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17 pages, 3324 KiB  
Article
Revealing the True Morphological Structure of Macroporous Soft Hydrogels for Tissue Engineering
by Bohumila Podhorská, Miroslav Vetrík, Eva Chylíková-Krumbholcová, Lucie Kománková, Niloufar Rashedi Banafshehvaragh, Miroslav Šlouf, Miroslava Dušková-Smrčková and Olga Janoušková
Appl. Sci. 2020, 10(19), 6672; https://doi.org/10.3390/app10196672 - 24 Sep 2020
Cited by 18 | Viewed by 3787
Abstract
(1) Background: Macroporous hydrogel scaffolds based on poly [N-(2-hydroxypropyl) methacrylamide] are one of the widely studied biocompatible materials for tissue reparation and regeneration. This study investigated the morphological changes during hydrogel characterization which can significantly influence their future application. (2) Methods: Three types [...] Read more.
(1) Background: Macroporous hydrogel scaffolds based on poly [N-(2-hydroxypropyl) methacrylamide] are one of the widely studied biocompatible materials for tissue reparation and regeneration. This study investigated the morphological changes during hydrogel characterization which can significantly influence their future application. (2) Methods: Three types of macroporous soft hydrogels differing in pore size were prepared. The macroporosity was achieved by the addition of sacrificial template particles of sodium chloride of various sizes (0–30, 30–50, and 50–90 µm) to the polymerizing mixture. The 3D structure of the hydrogels was then investigated by scanning electron microscopy (SEM) and laser scanning confocal microscopy (LSCM). The SEM was performed with specimens rapidly frozen to various temperatures, while non-frozen gels were visualized with LSCM. (3 and 4) Results and Conclusion: In comparison to LSCM, the SEM images revealed a significant alteration in the mean pore size and appearance of newly formed multiple connections between the pores, depending on the freezing conditions. Additionally, after freezing for SEM, the gel matrix between the pores and the fine pores collapsed. LSCM visualization aided the understanding of the dynamics of pore generation using sodium chloride, providing the direct observation of hydrogel scaffolds with the growing cells. Moreover, the reconstructed confocal z-stacks were a promising tool to quantify the swollen hydrogel volume reconstruction which is not possible with SEM. Full article
(This article belongs to the Special Issue Polymer Scaffolds for Tissue Engineering Applications)
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