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Applied Sciences
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Advance in Cancer, Chemotherapy and Periodontal Disease
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Advance in Cancer, Chemotherapy and Periodontal Disease

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: closed (15 April 2022) | Viewed by 25805

Special Issue Editor

Dr. Ionut Luchian

E-Mail Website
Guest Editor
Department of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Interests: salivary research; ortho-perio; cytokines; biomarkers; finite element method; periodontology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Distinguished colleagues,

It is our great honor to announce that a new Special Issue is now open for submissions in the prestigious Applied Sciences journal.
The area of interference between periodontal and systemic diseases is widely debated in the scientific environment. For years, extensive research has been published about the interrelationship between the general pathology and the periodontal one but the literature still does not have enough evidence regarding the link between cancer periodontal affections. For this reason, we are launching this Special Issue as a brilliant opportunity to publish your valuable work in this field.
Chemotherapy is a main component in the therapeutic protocol of cancer, but we should not ignore the common side effects of it that can be noticed both systemically and locally.
Although the main target of chemotherapy is malignant cells, some specific tissues can be affected and among them are the oral ones. At the oral level, we can notice many changes that affect the soft tissues and have a significant influence on the prognosis and progression of periodontal disease.
In the following, you can find some proposed topics for this Special Issue (not a limited list):

  • Periodontal disease and the quality of life associated to cancer;
  • Cytotoxicity at the periodontal level associated with chemotherapy;
  • Special biochemical mechanisms in periodontal disease and cancer;
  • The link between oral cancer and periodontal affections;
  • Toxicological impact of chemotherapy at the periodontal level.

We are very much looking forward to receiving your outstanding papers and we are sure that you will contribute significantly to the scientific development in this important area!

Dr. Ionut Luchian
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontal disease
  • chemotherapy
  • cancer
  • cytotoxicity
  • toxicology
  • side effects
  • immune suppression
  • systemic diseases

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Published Papers (7 papers)

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Research

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16 pages, 302 KiB  
Article
The Quantification of Salivary Flow and pH and Stomatognathic System Rehabilitation Interference in Patients with Oral Diseases, Post-Radiotherapy
by Bogdan Petru Bulancea, Laura Elisabeta Checherita, Georgeta Liliana Foia, Ovidiu Stamatin, Silvia Teslaru, Iulian Costin Lupu, Delia Gabriela Ciobanu, Eduard-Radu Cernei, Grierosu Carmen, Mariana Postolache, Eliza Maria Froicu, Liliana Gabriela Halitchi and Liana Aminov
Appl. Sci. 2022, 12(8), 3708; https://doi.org/10.3390/app12083708 - 7 Apr 2022
Cited by 2 | Viewed by 2474
Abstract
Xerostomia is a common complication post-radiotherapy in patients with oral cancer. The acute and long-term side effects can considerably reduce the patient’s quality of life. The aim of our study was to perform analysis of salivary flow and pH in patients after radiotherapy. [...] Read more.
Xerostomia is a common complication post-radiotherapy in patients with oral cancer. The acute and long-term side effects can considerably reduce the patient’s quality of life. The aim of our study was to perform analysis of salivary flow and pH in patients after radiotherapy. Methodology: Clinical and laboratory evaluations were conducted in the 2014–2019 period; out of a total 58 subjects aged between 45 and 84, 28 individuals with oral cancer were selected from St. Spiridon Hospital, Clinic of Maxillo-facial Surgery and Oncology Hospital, Iasi post-radiotherapy. Results: Significant downsized mean values of the hydrogen ion concentration (pH) in saliva (p < 0.001) were recorded in patients after radiotherapy, pH value = 4.580 (±1.051). The mean value of resting salivary flow (MRSF) was significantly lower for the group of patients with radiotherapy (MRSF) = 0.145 mL/min. In 89.29% of cases (25 post-radiotherapy cases), in order to perform oral complex rehabilitation treatment, several endodontic and periodontal treatments were performed. A total of 78.57% of the cases received complex oral rehabilitation as mobile or hybrid prostheses or fixed solutions. Conclusion: Understanding post-radiotherapy salivary biochemic modifications in patients with oral cancer could be of critical importance, in view of related oral disorder prevention. Full article
(This article belongs to the Special Issue Advance in Cancer, Chemotherapy and Periodontal Disease)
13 pages, 707 KiB  
Article
Understanding the Pattern of Oropharyngeal Cancers from North-East Romanian Patients
by Ramona Gabriela Ursu, Simona Eliza Giusca, Irene Alexandra Spiridon, Bianca Manole, Mihai Danciu, Victor Vlad Costan, Dragos Octavian Palade, Nicolae Ghetu, Paula Toader, Mădălina Alexandra Vlad, Costin Damian, Elena Porumb-Andrese, Ionut Luchian and Luminița Smaranda Iancu
Appl. Sci. 2021, 11(24), 12079; https://doi.org/10.3390/app112412079 - 18 Dec 2021
Cited by 4 | Viewed by 3315
Abstract
Background: Human papilloma virus (HPV) is acknowledged as a risk factor for oropharyngeal squamous cellular cancers (OPSCC), of which the dominant types are tonsillar (TSCC) and base of tongue cancer (BOTSCC). Objective: To assess the role of HPV in selected OPSCC cases, from [...] Read more.
Background: Human papilloma virus (HPV) is acknowledged as a risk factor for oropharyngeal squamous cellular cancers (OPSCC), of which the dominant types are tonsillar (TSCC) and base of tongue cancer (BOTSCC). Objective: To assess the role of HPV in selected OPSCC cases, from Romanian patients by sensitive and complementary molecular assays. Material and Methods: Fifty-four formalin fixed paraffin embedded (FFPE) OPSCC samples were analyzed for HPV DNA by a PCR-based bead-based multiplex-assay. Thirty-four samples were tested for HPV RNA and for overexpression of p16INK4a by immunohistochemistry. Twenty samples were evaluated by Competitive Allele-Specific Taqman PCR (CAST-PCR) for fibroblast growth factor receptor 3 protein (FGFR3) status. Results: A total of 33.3% (18/54) OPSCC samples were positive for HPV DNA. HPV16 was the most frequent type (30%, 16/54); followed by HPV18 (3.7%, 2/54); and 1 sample (1.8%) was positive for both HPV16 and 18. HPV18 E6*I was detected in a HPV18 DNA-positive oropharynx tumor. Four samples positive for HPV16 were also positive for p16INK4a. All the tested samples were negative for FGFR3. Conclusions: The increased HPV16 prevalence is in line with similar studies and is a new confirmation that HPV16 is the most prevalent type in our country; supporting the potential benefit of prophylactic vaccines. Overall, there is no concordance between DNA and any of the two other analytes that are considered being markers of HPV-driven cancers. There is a need to explore novel screening strategies that could be broadly used in the clinical routine to initiate preventive measures. Full article
(This article belongs to the Special Issue Advance in Cancer, Chemotherapy and Periodontal Disease)
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10 pages, 582 KiB  
Article
Emerging Oncogenic Viruses in Head and Neck Cancers from Romanian Patients
by Ramona Gabriela Ursu, Ionut Luchian, Nicolae Ghetu, Victor Vlad Costan, Ovidiu Stamatin, Octavian Dragos Palade, Costin Damian, Luminita Smaranda Iancu and Elena Porumb-Andrese
Appl. Sci. 2021, 11(19), 9356; https://doi.org/10.3390/app11199356 - 8 Oct 2021
Cited by 10 | Viewed by 2977
Abstract
(1) Background: Head and neck squamous cell carcinomas (HNSCCs) are some of the most frequent malignancies globally. Oncogenic viruses MCPyV, EBV and HPVs are recognized to be related to HNSCCs and skin cancers. There are no data from Romania regarding the involvement of [...] Read more.
(1) Background: Head and neck squamous cell carcinomas (HNSCCs) are some of the most frequent malignancies globally. Oncogenic viruses MCPyV, EBV and HPVs are recognized to be related to HNSCCs and skin cancers. There are no data from Romania regarding the involvement of herpes viruses and polyomaviruses in these types of cancer. We aim to evaluate the association of oncogenic viruses from Papillomaviridae, Herpesviridae, and Polyomaviridae families in HNSCCs and skin cancers. (2) Methods: A total of 26 fresh tumors (6/26 women) were tested for 67 viral agents using a multiplex PCR genotyping assay. (3) Results: A total of 23/26 (88.5%) samples were positive for one or more viruses. All the tested tumors were negative for any HPV (alpha or beta types). In total, we detected as positive samples: 16 (61.63%) EBV1, 12 (46.15%) HHV7, 8 (30.76%) MCV, 6 (23.07%) CMV and HHV6, 2 (7.69%) HHV8, 1 (3.8%) HPyV6 and EBV2. (4) Conclusions: We detected HPV-negative cases that are HPyV and HHV positive. In these fractions of HPV-negative HNSCCs cases, other oncogenic viruses may be involved, such as EBV1, MCV or CMV. Additional research is required for clarifying the natural history of these viruses in HNSCCs, as virus detection would have a decisive impact on diagnostic and decisional algorithms. Full article
(This article belongs to the Special Issue Advance in Cancer, Chemotherapy and Periodontal Disease)
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9 pages, 1599 KiB  
Article
Determining Chemotherapy Agents in Saliva through Spectrometry and Chromatography Methods Correlated with Periodontal Status in Oncology Patients
by Diana Cristala Kappenberg Niţescu, Liliana Păsărin, Silvia Mârţu, Cornelia Teodorescu, Bogdan Vasiliu, Ioana Mârţu, Ionut Luchian and Sorina Mihaela Solomon
Appl. Sci. 2021, 11(13), 5984; https://doi.org/10.3390/app11135984 - 27 Jun 2021
Cited by 3 | Viewed by 2454
Abstract
Background: The aim of this study is to quantify chemotherapy agents in the saliva of oncology patients undergoing intravenous chemotherapy treatment, and evaluate the oral and periodontal clinical modifications and possible correlations between them. Materials and Methods: The study was conducted on 29 [...] Read more.
Background: The aim of this study is to quantify chemotherapy agents in the saliva of oncology patients undergoing intravenous chemotherapy treatment, and evaluate the oral and periodontal clinical modifications and possible correlations between them. Materials and Methods: The study was conducted on 29 patients undergoing chemotherapy treatment with cisplatin, oxaliplatin or gemcitabine. Three total saliva samples were gathered from each patient in three key points regarding chemotherapy. The samples were then analyzed through methods of mass spectrometry and liquid chromatography. Results: Cisplatin and gemcitabine were only found in saliva at 30 min and 2 h after chemotherapy administration, however oxaliplatin was determined in all three samples. Clinically, the most accentuated clinical attachment loss and CPITN scores were observed on mandibular teeth, whereas the highest values for the Sillness and Loe gingival index and gingival bleeding index were in the lateral maxillary areas. We found no statistically significant correlation between the periodontal parameters and chemotherapy concentration in saliva. Conclusion: A fraction of systemically administered chemotherapy can also be found in the saliva of oncology patients and have the potential to exacerbate oral infections and cause local and systemic complications throughout the oncology treatment. Further research is required in order to fully understand how chemotherapy can influence the development of periodontal disease. Full article
(This article belongs to the Special Issue Advance in Cancer, Chemotherapy and Periodontal Disease)
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Review

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13 pages, 694 KiB  
Review
The Link between Periodontal Disease and Oral Cancer—A Certainty or a Never-Ending Dilemma?
by Zinovia Surlari, Dragoș Ioan Virvescu, Elena-Raluca Baciu, Roxana-Ionela Vasluianu and Dana Gabriela Budală
Appl. Sci. 2021, 11(24), 12100; https://doi.org/10.3390/app112412100 - 19 Dec 2021
Cited by 3 | Viewed by 4588
Abstract
Periodontal disease can have a substantial systemic influence on the body that extends beyond the oral cavity and can lead to local inflammation, bone damage, and tooth loss. A great number of studies suggest that periodontitis and oral cancer are linked, however it [...] Read more.
Periodontal disease can have a substantial systemic influence on the body that extends beyond the oral cavity and can lead to local inflammation, bone damage, and tooth loss. A great number of studies suggest that periodontitis and oral cancer are linked, however it is unclear if specific periodontal bacteria promote the development of systemic illness. The mediators of the relationship between those two pathologies are still being discovered, but the research findings indicate the existence of a correlation. Additional research, including confounding factors, is needed to strengthen this link. Full article
(This article belongs to the Special Issue Advance in Cancer, Chemotherapy and Periodontal Disease)
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19 pages, 1932 KiB  
Review
Electronic Cigarettes’ Toxicity: From Periodontal Disease to Oral Cancer
by Alexandra Jităreanu, Luminița Agoroaei, Ovidiu Dumitru Aungurencei, Ancuța Goriuc, Diana Diaconu Popa, Carmen Savin, Ioana-Cezara Caba, Simona Tătărușanu, Bianca Profire and Ioana Mârțu
Appl. Sci. 2021, 11(20), 9742; https://doi.org/10.3390/app11209742 - 19 Oct 2021
Cited by 7 | Viewed by 4886
Abstract
Electronic nicotine delivery systems first appeared on the market in 2003 and have been promoted as healthier alternatives to conventional tobacco cigarettes. The rapid evolution of technology for these products generated a wide variety of models, and electronic cigarettes have quickly gained worldwide [...] Read more.
Electronic nicotine delivery systems first appeared on the market in 2003 and have been promoted as healthier alternatives to conventional tobacco cigarettes. The rapid evolution of technology for these products generated a wide variety of models, and electronic cigarettes have quickly gained worldwide popularity. However, research regarding the effects of both short-term and long-term exposure revealed a wide variety of potential negative effects on human health, and the first system to be affected by these electronic smoking devices is the oral cavity. This review makes an up-to-date extensive presentation of the possible mechanisms that associate electronic cigarette smoking with increased prevalence and progression of oral cancer. Oxidative stress, inflammation response, and DNA damage are the main mechanisms that explain e-cigarettes’ cytotoxicity, but there are still questions to be answered. At present, tens of thousands of e-liquids are available, with distinct compositions, which makes the research even more challenging. Another aspect approached in the present paper is the effect of nicotine on chemotherapy drug resistance. Nicotine activates nicotinic acetylcholine receptors, consecutively inhibiting apoptosis, increasing tumor cells proliferation and survival, and reducing the effects of chemotherapy drugs. Full article
(This article belongs to the Special Issue Advance in Cancer, Chemotherapy and Periodontal Disease)
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Other

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9 pages, 1295 KiB  
Systematic Review
The Presence of Periodontitis in Patients with Von Willebrand Disease: A Systematic Review
by Alexandru Mester, Leonardo Mancini, Enrico Marchetti, Mihaela Baciut, Simion Bran, Ondine Lucaciu, Grigore Baciut, Ciprian Tomuleasa, Sergiu Pasca, Andra Piciu, Andrada Voina-Tonea, Horia Opris, Daiana Antoaneta Prodan and Florin Onisor
Appl. Sci. 2021, 11(14), 6408; https://doi.org/10.3390/app11146408 - 12 Jul 2021
Viewed by 3793
Abstract
The aim of this systematic review and meta-analysis was to analyze the available evidence on the assessment of periodontal disease in patients with von Willebrand disease (VWD). An electronic search in three databases (PubMed, Web of Science, and Scopus) was conducted by three [...] Read more.
The aim of this systematic review and meta-analysis was to analyze the available evidence on the assessment of periodontal disease in patients with von Willebrand disease (VWD). An electronic search in three databases (PubMed, Web of Science, and Scopus) was conducted by three independent reviewers to identify cross-sectional, cohort, and clinical trial studies. Studies considered eligible for this review were evaluated according to the quality and risk assessment tool proposed by the CLARITY Group at McMaster University. In order to analyze the possible correlation of VWD patients and periodontitis and their susceptibility to bleeding during the periodontal screening phase, periodontal parameters evaluated were probing pocket depth (PPD), bleeding on probing (BOP), gingival bleeding index (GBI), and periodontal inflamed surface area (PISA). After a screening of 562 articles, three articles were selected for the qualitative analysis. Within the limitation of our review, VWD patients are not more susceptible to periodontitis as compared with non-VWD patients. Nevertheless, bleeding on probing and gingival index needs to be carefully taken into consideration during periodontal screening of VWD due to the possible presence of false positives. Full article
(This article belongs to the Special Issue Advance in Cancer, Chemotherapy and Periodontal Disease)
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