Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.3
2.4
Journals
Medicina
Special Issues
Advances in Clinical Medicine and Dentistry
share announcement

Advances in Clinical Medicine and Dentistry

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry and Oral Health".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 1746

Special Issue Editors

Prof. Dr. Radu Iliescu

E-Mail Website
Guest Editor
Department of Pharmacology, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Interests: physiology; pharmacology; baroreflex; blood pressure; hypertension; heart rate; cardiovascular
Special Issues, Collections and Topics in MDPI journals
Dr. Ionut Luchian

E-Mail Website
Guest Editor
Department of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Interests: salivary research; ortho-perio; cytokines; biomarkers; finite element method; periodontology
Special Issues, Collections and Topics in MDPI journals
Dr. Mihaela Moscalu

E-Mail Website
Guest Editor
Department of Preventive Medicine and Interdisciplinarity, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Interests: physiology; biomarker; predictive modeling; risk classification methods; biostatistics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The involvement of biomarkers in predictive modeling and their inclusion in the risk assessment of clinical events has seen significant development in recent years. These aspects are essential for personalized medicine, allowing for tailored approaches to disease prevention, diagnosis, treatment and monitoring. Biomarkers are key to an early and accurate diagnosis, as well as risk assessment and prognosis, providing measurable indicators of individual characteristics and guiding personalized treatment strategies.

This Special Issue aims to collect papers that highlight the use of biomarkers in preventive, diagnostic, therapeutic and prognostic medicine. We also focus our attention on the involvement of biomarkers in public health and their current use in clinical practice.

Currently, there are only a limited number of predictors available, but the development and addition of predictive markers could have a significant impact. Interest in biomarkers has increased, and new methodologies have been developed to evaluate their utility. Biomarker discovery and validation are of particular interest for the advancement of personalized medicine. Analytical techniques are available to quantify the added value of biomarkers, highlighting both their strengths and limitations. While some biomarkers may be relevant to both clinical medicine and dentistry, dentistry has its own unique set of biomarkers that are relevant to oral health, diagnosis and management of dental conditions. In the future, preventive and predictive biomarkers will play a key role in healthcare.

Original articles, reviews, systematic reviews, meta-analyses and case reports are welcomed.

Prof. Dr. Radu Iliescu
Dr. Ionut Luchian
Dr. Mihaela Moscalu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • physiology
  • biomarker
  • predictive modeling
  • risk classification methods
  • salivary diagnosis
  • cytokines
  • systemic diseases
  • genetics
  • microbiology
  • pharmacology
  • biostatistics

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Related Special Issue

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 1371 KiB  
Article
Impact of Infrabony Defects Treatment on Periodontal Markers and Glycated Hemoglobin Using Platelet-Rich Fibrin, Guided Tissue Regeneration, and Access-Flap Surgery
by Ada Stefanescu, Irina-Georgeta Sufaru, Cristian Martu, Diana-Maria Anton, Gabriel Rotundu and Kamel Earar
Medicina 2024, 60(11), 1769; https://doi.org/10.3390/medicina60111769 - 29 Oct 2024
Viewed by 485
Abstract
Background and Objectives: This study evaluated the outcomes of single open-flap debridement, open-flap debridement (OFD) plus resorbable membrane placement, and OFD with resorbable membrane placement plus platelet-rich fibrin (PRF) in terms of periodontal clinical parameters and glycated hemoglobin (HbA1c) levels in 24 [...] Read more.
Background and Objectives: This study evaluated the outcomes of single open-flap debridement, open-flap debridement (OFD) plus resorbable membrane placement, and OFD with resorbable membrane placement plus platelet-rich fibrin (PRF) in terms of periodontal clinical parameters and glycated hemoglobin (HbA1c) levels in 24 adult patients with stage 3 grade C periodontitis and type II diabetes mellitus. Materials and Methods: The primary outcome measure for this study was the clinical attachment level (CAL); secondary outcomes included additional periodontal parameters, such as the plaque index (PI), bleeding on probing (BOP), probing depth (PD), as well as glycated hemoglobin (HbA1c) levels to evaluate the systemic impact of the treatments on glycemic control. The parameters were assessed before and at three and six months post-surgery. In Group A, the flap was sutured closed; in Group B, an absorbable collagen membrane was placed over the defect; and in Group C, PRF was utilized in the defect, with two additional PRF membranes used to cover the defect. The wound healing index (WHI) was recorded at 7 and 14 days after the surgery. Results: The initial findings indicated no significant differences in the periodontal parameters among the three groups. However, improvements in the PD and CAL were most notable in Group C, followed by Group B, with Group A showing the slightest improvement. At six months, there was a highly significant difference in the CAL (p < 0.001). Group C (4.92 ± 0.35) and Group B (4.99 ± 0.31) demonstrated the most significant improvements in the CAL compared to Group A (5.89 ± 0.57). At seven days post-surgery, Group C demonstrated significant healing, with 85% of the sites showing complete healing. By the 14-day mark, all sites in Group C indicated complete healing. Although the HbA1c values did not exhibit statistically significant differences among the groups at baseline, at the 6-month evaluation, all groups showed significantly lower values than baseline. However, the comparison between groups revealed significantly improved values for Group C. Conclusions: The study’s results suggest that PRF is an exceptional material for infrabony defects treatment and notably improves HbA1c levels. Full article
(This article belongs to the Special Issue Advances in Clinical Medicine and Dentistry)
►▼ Show Figures

Figure 1

10 pages, 294 KiB  
Article
The Influence of Dental Status and Blood Parameters Characterizing Endogenous Intoxication on the Timing of Childbirth
by Maria Hakobyan, Gayane Manrikyan, Marina Markaryan, Izabella Vardanyan and Mikayel Manrikyan
Medicina 2024, 60(7), 1176; https://doi.org/10.3390/medicina60071176 - 19 Jul 2024
Viewed by 836
Abstract
Background and Objectives: Epidemiological and microbiological–immunological studies have led to the conclusion that periodontal disease may be a risk factor for preterm birth. The aim of this study was to investigate and identify the relationship of some hematological cellular biomarkers characterizing the [...] Read more.
Background and Objectives: Epidemiological and microbiological–immunological studies have led to the conclusion that periodontal disease may be a risk factor for preterm birth. The aim of this study was to investigate and identify the relationship of some hematological cellular biomarkers characterizing the chronic oral focus of infection with pregnancy outcomes and their impact on those outcomes. Materials and Methods: Clinical and laboratory tests were conducted on 100 pregnant women, grouped by full-term or preterm births, with the assessment of the following markers: DMF, CPI and PIRI, PHP, microbiological examination of periodontal pockets and amniotic fluid, WBS count, WBCSI, LGI, and NMR. A statistical analysis was carried out with SPSS Statistics version 19.0. Results: Women with preterm labor had higher-grade caries (CSL > 0.3), while women with full-term childbirth had moderate caries (CSL < 0.3). A satisfactory level of oral hygiene efficiency was found in 50% (group 1) and 38.1% (group 2) of the expectant mothers. The periodontal status by the PIRI showed tissue lesions in 20.7% (group 1) and 92.9% (group 2) of the women. The WBCSI was 2.27 ± 0.82 and 2.15 ± 0.68, the NMR was 9.29 ± 5.119 and 11.62 ± 7.78, and the LGI was 3.54 ± 1.1 and 3.73 ± 0.81 in groups 1 and 2, respectively. Comparative analysis of bacterial contamination of the amniotic fluid revealed the predominance of Fusobacterium nucleatum (64.3%), Tannerella forsythia (57.1%), Prevotella intermedia (50%), Porphyromonas gingivalis (57.1%), Staphylococcus aureus (45.2%), and Candida albicans (50%) in women with premature birth. Conclusions: In women with preterm birth, the values of the indices characterizing a chronic oral focus of infection evoke more significant correlations with the timing of delivery, which indicates the significant role of an oral focus of infection. The presence of microbial invasion of amniotic fluid may indicate the role of periodontopathogenic bacteria in pregnant women diagnosed with a risk of preterm birth. Full article
(This article belongs to the Special Issue Advances in Clinical Medicine and Dentistry)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop