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Bioengineering
Special Issues
Nano-Based Drug Delivery System: Recent Developments and Future Prospects
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Nano-Based Drug Delivery System: Recent Developments and Future Prospects

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanobiotechnology and Biofabrication".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 16084

Special Issue Editors

Dr. Venkata Krishna Kowthavarapu

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Guest Editor
Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA
Interests: nanomedicin; polymer synthesis; lipid-based nanoparticles; biopharmaceutics; neurodegenerative disease; biomaterials; in-vitro product performance; PBPK modeling and simulations
Dr. Nitin Charbe

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Guest Editor
Center for Pharmacometrics & Systems Pharmacology, Department of Pharmaceutics (Lake Nona), University of Florida, Orlando, FL, USA
Interests: nanomedicine; targeted drug delivery; bioanalysis; formulation & development; physiological based pharmacokinetic modeling and simulation

Special Issue Information

Dear Colleagues,

The rise of nanotechnology has resulted in a new focus on advanced techniques of drug delivery. In recent years, there has been a surge of interest in using nanotechnology to solve the issues with gene and drug delivery. Drug and gene delivery applications have prompted the substantial study of nanosystems with a wide range of compositions and biological features. Researchers have discovered a variety of compounds with intriguing biological features, but low bioavailability (owing to issues such as poor solubility, toxicities, rapid clearance, metabolic degradation, and the inability to pass the blood–brain and intestinal barriers). Therefore, nanocarriers may be the most effective method for achieving targeted drug delivery to a specific location over a prolonged period of time and at a predetermined dosage. Nanocarriers allow for controlled and prolonged medication release at the treatment site. The drug's bioavailability, half-life, and metabolic stability are all improved by their use. Currently, a wide variety of biodegradable nanocarriers are accessible and commercially available as medication. This Special Issue's primary goal is to investigate the state of nanoparticles as drug delivery systems and elaborate their potential future scope.

Research papers, reviews, and communication reports on the keywords listed below are all welcome in this Special Issue.

Dr. Venkata Krishna Kowthavarapu
Dr. Nitin Charbe
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomedicine
  • polymeric nanoparticles
  • siRNA delivery
  • mRNA delivery
  • lipid-based drug delivery systems
  • liposomes
  • targeted drug delivery systems
  • nanotherapeutics
  • biomaterials

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Published Papers (5 papers)

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Research

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19 pages, 1871 KiB  
Article
Systematic Screening Study for the Selection of Proper Stabilizers to Produce Physically Stable Canagliflozin Nanosuspension by Wet Milling Method
by Yagmur Pirincci Tok, Burcu Mesut, Sevgi Güngör, Ali Osman Sarıkaya, Emre Erol Aldeniz, Udaya Dude and Yıldız Özsoy
Bioengineering 2023, 10(8), 927; https://doi.org/10.3390/bioengineering10080927 - 4 Aug 2023
Cited by 4 | Viewed by 1838
Abstract
One of the crucial approaches to managing the low solubility and weak bioavailability of drugs is via nanocrystal technology. Through this technology, drug particles have an increased solubility and a faster dissolution rate due to high surface free energy, which requires an appropriate [...] Read more.
One of the crucial approaches to managing the low solubility and weak bioavailability of drugs is via nanocrystal technology. Through this technology, drug particles have an increased solubility and a faster dissolution rate due to high surface free energy, which requires an appropriate stabilizer(s) to prevent instabilities during the manufacturing process and storage of the nanosuspension. This study aimed to establish a scientific predictive system for properly selecting stabilizers or to reduce the attempts on a trial-and-error basis in the wet-milling method. In total, 42 experiments were performed to examine the effect of critical material attributes on the wettability of the drug, the saturation solubility in the stabilizer solutions or combinations thereof and the dynamic viscosity of stabilizer solutions. All data were evaluated by Minitab 19® and an optimization study was performed. The optimized formulation at a certain concentration of stabilizer combination was ground by Dyno Mill® with 0.3 mm beads for one hour. The optimized nanosuspension with a particle size of 204.5 nm was obtained in short milling time and offered 3.05- and 3.51 times better dissolution rates than the marketed drug product (Invokana® 100 mg) in pH 4.5 and pH 6.8 as non-sink conditions, respectively. The formulation was monitored for three months at room temperature and 4 °C. The parameters were 261.30 nm, 0.163, −14.1 mV and 261.50 nm, 0.216 and −17.8 mV, respectively. It was concluded that this approach might indicate the appropriate selection of stabilizers for the wet-milling process. Full article
(This article belongs to the Special Issue Nano-Based Drug Delivery System: Recent Developments and Future Prospects)
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17 pages, 4497 KiB  
Article
Echogenic Advantages of Ferrogels Filled with Magnetic Sub-Microparticles
by Olga A. Dinislamova, Antonina V. Bugayova, Tatyana F. Shklyar, Alexander P. Safronov and Felix A. Blyakhman
Bioengineering 2021, 8(10), 140; https://doi.org/10.3390/bioengineering8100140 - 11 Oct 2021
Cited by 3 | Viewed by 2578
Abstract
Ultrasonic imaging of ferrogels (FGs) filled with magnetic nanoparticles does not reflect the inner structure of FGs due to the small size of particles. To determine whether larger particle size would improve the acoustic properties of FGs, biocompatible hydrogels filled with 100–400 nm [...] Read more.
Ultrasonic imaging of ferrogels (FGs) filled with magnetic nanoparticles does not reflect the inner structure of FGs due to the small size of particles. To determine whether larger particle size would improve the acoustic properties of FGs, biocompatible hydrogels filled with 100–400 nm iron oxide magnetic sub-microparticles with weight fraction up to 23.3% were synthesized and studied. Polymeric networks of synthesized FGs were comprised of chemically cross-linked polyacrylamide with interpenetrating physical network of natural polysaccharide—Guar or Xanthan. Cylindrical samples approximately 10 mm in height and 13 mm in diameter were immersed in a water bath and examined using medical ultrasound (8.5 MHz). The acoustic properties of FGs were characterized by the intensity of reflected echo signal. It was found that the echogenicity of sub-microparticles provides visualization not only of the outer geometry of the gel sample but of its inner structure as well. In particular, the echogenicity of FGs interior depended on the concentration of magnetic particles in the FGs network. The ultrasound monitoring of the shape, dimensions, and inner structure of FGs in the applied external magnetic field is demonstrated. It is especially valuable for the application of FGs in tissue engineering and regenerative medicine. Full article
(This article belongs to the Special Issue Nano-Based Drug Delivery System: Recent Developments and Future Prospects)
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15 pages, 4832 KiB  
Article
Amphiphilic and Perfluorinated Poly(3-Hydroxyalkanoate) Nanocapsules for 19F Magnetic Resonance Imaging
by Marion Le Gal, Estelle Renard, Christelle Simon-Colin, Benoit Larrat and Valérie Langlois
Bioengineering 2021, 8(9), 121; https://doi.org/10.3390/bioengineering8090121 - 9 Sep 2021
Cited by 2 | Viewed by 3351
Abstract
Nanoparticles have recently emerged as valuable tools in biomedical imaging techniques. Here PEGylated and fluorinated nanocapsules based on poly(3-hydroxyalkanoate) containing a liquid core of perfluorooctyl bromide PFOB were formulated by an emulsion-evaporation process as potential 19F MRI imaging agents. Unsaturated poly(hydroxyalkanoate), PHAU, [...] Read more.
Nanoparticles have recently emerged as valuable tools in biomedical imaging techniques. Here PEGylated and fluorinated nanocapsules based on poly(3-hydroxyalkanoate) containing a liquid core of perfluorooctyl bromide PFOB were formulated by an emulsion-evaporation process as potential 19F MRI imaging agents. Unsaturated poly(hydroxyalkanoate), PHAU, was produced by marine bacteria using coprah oil and undecenoic acid as substrates. PHA-g-(F; PEG) was prepared by two successive controlled thiol-ene reactions from PHAU with firstly three fluorinated thiols having from 3 up to 17 fluorine atoms and secondly with PEG-SH. The resulting PHA-g-(F; PEG)-based PFOB nanocapsules, with a diameter close to 250–300 nm, are shown to be visible in 19F MRI with an acquisition time of 15 min. The results showed that PFOB-nanocapsules based on PHA-g-(F; PEG) have the potential to be used as novel contrast agents for 19F MRI. Full article
(This article belongs to the Special Issue Nano-Based Drug Delivery System: Recent Developments and Future Prospects)
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27 pages, 5961 KiB  
Review
Advances in siRNA Drug Delivery Strategies for Targeted TNBC Therapy
by Md Abdus Subhan and Vladimir P. Torchilin
Bioengineering 2024, 11(8), 830; https://doi.org/10.3390/bioengineering11080830 - 14 Aug 2024
Viewed by 1988
Abstract
Among breast cancers, triple-negative breast cancer (TNBC) has been recognized as the most aggressive type with a poor prognosis and low survival rate. Targeted therapy for TNBC is challenging because it lacks estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor [...] Read more.
Among breast cancers, triple-negative breast cancer (TNBC) has been recognized as the most aggressive type with a poor prognosis and low survival rate. Targeted therapy for TNBC is challenging because it lacks estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Chemotherapy, radiation therapy, and surgery are the common therapies for TNBC. Although TNBC is prone to chemotherapy, drug resistance and recurrence are commonly associated with treatment failure. Combination therapy approaches using chemotherapy, mAbs, ADC, and antibody–siRNA conjugates may be effective in TNBC. Recent advances with siRNA-based therapy approaches are promising for TNBC therapy with better prognosis and reduced mortality. This review discusses advances in nanomaterial- and nanobiomaterial-based siRNA delivery platforms for TNBC therapy exploring targeted therapy approaches for major genes, proteins, and TFs upregulated in TNBC tumors, which engage in molecular pathways associated with low TNBC prognosis. Bioengineered siRNA drugs targeting one or several genes simultaneously can downregulate desired genes, significantly reducing disease progression. Full article
(This article belongs to the Special Issue Nano-Based Drug Delivery System: Recent Developments and Future Prospects)
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23 pages, 1644 KiB  
Review
Advances in Magnetic Nanoparticles Engineering for Biomedical Applications—A Review
by Abdulkader Baki, Frank Wiekhorst and Regina Bleul
Bioengineering 2021, 8(10), 134; https://doi.org/10.3390/bioengineering8100134 - 30 Sep 2021
Cited by 33 | Viewed by 5577
Abstract
Magnetic iron oxide nanoparticles (MNPs) have been developed and applied for a broad range of biomedical applications, such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery, gene therapy and tissue repair. As one key element, reproducible synthesis routes of MNPs are capable [...] Read more.
Magnetic iron oxide nanoparticles (MNPs) have been developed and applied for a broad range of biomedical applications, such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery, gene therapy and tissue repair. As one key element, reproducible synthesis routes of MNPs are capable of controlling and adjusting structure, size, shape and magnetic properties are mandatory. In this review, we discuss advanced methods for engineering and utilizing MNPs, such as continuous synthesis approaches using microtechnologies and the biosynthesis of magnetosomes, biotechnological synthesized iron oxide nanoparticles from bacteria. We compare the technologies and resulting MNPs with conventional synthetic routes. Prominent biomedical applications of the MNPs such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery and magnetic actuation in micro/nanorobots will be presented. Full article
(This article belongs to the Special Issue Nano-Based Drug Delivery System: Recent Developments and Future Prospects)
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