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Bioengineering
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Advances in Biomimetic Materials and Biomedical Devices
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Advances in Biomimetic Materials and Biomedical Devices

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 11828

Special Issue Editors

Dr. Wissam Farhat

E-Mail
Guest Editor
Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA
Interests: biomaterials; tissue engineering; 3D bioprinting; drug delivery devices
Special Issues, Collections and Topics in MDPI journals
Dr. Vincent Yeung

E-Mail Website
Guest Editor
Department of Ophthalmology, Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA
Interests: drug; exosomes; extracellular vesicles; EV cargo; nanoparticle; therapeutics

Special Issue Information

Dear Colleagues,

The term ‘biomaterials’ refers to substances that come in contact with tissues or biological fluids other than drugs that are used in therapeutic or diagnostic systems. Biomaterial science involves the collaboration of many academic disciplines, including material science, chemistry, biology, biophysics, biomechanics, pharmaceutical science, tissue engineering, and medicine, to provide therapeutic solutions for treating, repairing, or replacing diseased tissues and organs. Among their other uses, biomaterials are the root of many biomedical and pharmaceutical preparations. They are fundamental parts of drug delivery systems, from drug-eluting contact lenses to nanocarriers, and are the materials of choice in tissue engineering applications. In the last few years, massive developments have been made in the field of biomaterials, and research activities have led to improvements in the biomimetic features of designed tissue constructs and biomedical devices. This Special Issue of Bioengineering on “Advance in Applications of Biomimetic Materials and Biomedical Devices” will include original articles and reviews on the following topics:

  • 3D bioprinting of organs and tissue constructs;
  • Smart devices in the biomedical field;
  • Drug delivery systems and routes of administration;
  • 4D bioprinting for the fabrication of intelligent organs/tissues/devices;
  • Nanotechnology for drug delivery;
  • Stimuli-responsive materials and new chemistries in the biomedical area.

Dr. Wissam Farhat
Dr. Vincent Yeung
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • tissue engineering
  • nanotechnology
  • 3D and 4D bioprinting
  • smart materials
  • biomimetic
  • drug delivery systems

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Published Papers (4 papers)

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Research

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24 pages, 5730 KiB  
Article
Mesoporous Bioactive Glass-Incorporated Injectable Strontium-Containing Calcium Phosphate Cement Enhanced Osteoconductivity in a Critical-Sized Metaphyseal Defect in Osteoporotic Rats
by Seemun Ray, Ulrich Thormann, Inga Kramer, Ursula Sommer, Matthäus Budak, Matthias Schumacher, Anne Bernhardt, Anja Lode, Christine Kern, Marcus Rohnke, Christian Heiss, Katrin S. Lips, Michael Gelinsky and Volker Alt
Bioengineering 2023, 10(10), 1203; https://doi.org/10.3390/bioengineering10101203 - 16 Oct 2023
Viewed by 1828
Abstract
In this study, the in vitro and in vivo bone formation behavior of mesoporous bioactive glass (MBG) particles incorporated in a pasty strontium-containing calcium phosphate bone cement (pS100G10) was studied in a metaphyseal fracture-defect model in ovariectomized rats and compared to a plain [...] Read more.
In this study, the in vitro and in vivo bone formation behavior of mesoporous bioactive glass (MBG) particles incorporated in a pasty strontium-containing calcium phosphate bone cement (pS100G10) was studied in a metaphyseal fracture-defect model in ovariectomized rats and compared to a plain pasty strontium-containing calcium phosphate bone cement (pS100) and control (empty defect) group, respectively. In vitro testing showed good cytocompatibility on human preosteoblasts and ongoing dissolution of the MBG component. Neither the released strontium nor the BMG particles from the pS100G10 had a negative influence on cell viability. Forty-five female Sprague–Dawley rats were randomly assigned to three different treatment groups: (1) pS100 (n = 15), (2) pS100G10 (n = 15), and (3) empty defect (n = 15). Twelve weeks after bilateral ovariectomy and multi-deficient diet, a 4 mm wedge-shaped fracture-defect was created at the metaphyseal area of the left femur in all animals. The originated fracture-defect was substituted with pS100 or pS100G10 or left empty. After six weeks, histomorphometrical analysis revealed a statistically significant higher bone volume/tissue volume ratio in the pS100G10 group compared to the pS100 (p = 0.03) and empty defect groups (p = 0.0001), indicating enhanced osteoconductivity with the incorporation of MBG. Immunohistochemistry revealed a significant decrease in the RANKL/OPG ratio for pS100 (p = 0.004) and pS100G10 (p = 0.003) compared to the empty defect group. pS100G10 showed a statistically higher expression of BMP-2. In addition, a statistically significant higher gene expression of alkaline phosphatase, osteoprotegerin, collagen1a1, collagen10a1 with a simultaneous decrease in RANKL, and carbonic anhydrase was seen in the pS100 and pS100G10 groups compared to the empty defect group. Mass spectrometric imaging by time-of-flight secondary ion mass spectrometry (ToF-SIMS) showed the release of Sr2+ ions from both pS100 and pS100G10, with a gradient into the interface region. ToF-SIMS imaging also revealed that resorption of the MBG particles allowed for new bone formation in cement pores. In summary, the current work shows better bone formation of the injectable pasty strontium-containing calcium phosphate bone cement with incorporated mesoporous bioactive glass compared to the bioactive-free bone cement and empty defects and can be considered for clinical application for osteopenic fracture defects in the future. Full article
(This article belongs to the Special Issue Advances in Biomimetic Materials and Biomedical Devices)
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17 pages, 8215 KiB  
Article
Multifunctional Sodium Hyaluronate/Chitosan Foam Used as an Absorbable Hemostatic Material
by Ran Chen, Fanglin Du and Qipeng Yuan
Bioengineering 2023, 10(7), 868; https://doi.org/10.3390/bioengineering10070868 - 21 Jul 2023
Cited by 2 | Viewed by 1566
Abstract
Absorbable hemostatic materials have great potential in clinical hemostasis. However, their single coagulation mechanism, long degradation cycles, and limited functionality mean that they have restricted applications. Here, we prepared a sodium hyaluronate/carboxymethyl chitosan absorbable hemostatic foam (SHCF) by combining high-molecular-weight polysaccharide sodium hyaluronate [...] Read more.
Absorbable hemostatic materials have great potential in clinical hemostasis. However, their single coagulation mechanism, long degradation cycles, and limited functionality mean that they have restricted applications. Here, we prepared a sodium hyaluronate/carboxymethyl chitosan absorbable hemostatic foam (SHCF) by combining high-molecular-weight polysaccharide sodium hyaluronate with carboxymethyl chitosan via hydrogen bonding. SHCFs have rapid liquid absorption performance and can enrich blood cells. They transform into a gel when it they come into contact with blood, and are more easily degraded in this state. Meanwhile, SHCFs have multiple coagulation effects and promote hemostasis. In a rabbit liver bleeding model, SHCFs reduced the hemostatic time by 85% and blood loss by 80%. In three severe and complex bleeding models of porcine liver injury, uterine wall injury, and bone injury, bleeding was well-controlled and anti-tissue adhesion effects were observed. In addition, degradation metabolism studies show that SHCFs are 93% degraded within one day and almost completely metabolized within three weeks. The absorbable hemostatic foam developed in this study is multifunctional; with rapid hemostasis, anti-adhesion, and rapid degradation properties, it has great clinical potential for in vivo hemostasis. Full article
(This article belongs to the Special Issue Advances in Biomimetic Materials and Biomedical Devices)
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16 pages, 2813 KiB  
Article
Doxorubicin-Loaded Extracellular Vesicles Enhance Tumor Cell Death in Retinoblastoma
by Wissam Farhat, Vincent Yeung, Francesca Kahale, Mohit Parekh, John Cortinas, Lin Chen, Amy E. Ross and Joseph B. Ciolino
Bioengineering 2022, 9(11), 671; https://doi.org/10.3390/bioengineering9110671 - 10 Nov 2022
Cited by 14 | Viewed by 3057
Abstract
Chemotherapy is often used to treat retinoblastoma; however, this treatment method has severe systemic adverse effects and inadequate therapeutic effectiveness. Extracellular vesicles (EVs) are important biological information carriers that mediate local and systemic cell-to-cell communication under healthy and pathological settings. These endogenous vesicles [...] Read more.
Chemotherapy is often used to treat retinoblastoma; however, this treatment method has severe systemic adverse effects and inadequate therapeutic effectiveness. Extracellular vesicles (EVs) are important biological information carriers that mediate local and systemic cell-to-cell communication under healthy and pathological settings. These endogenous vesicles have been identified as important drug delivery vehicles for a variety of therapeutic payloads, including doxorubicin (Dox), with significant benefits over traditional techniques. In this work, EVs were employed as natural drug delivery nanoparticles to load Dox for targeted delivery to retinoblastoma human cell lines (Y-79). Two sub-types of EVs were produced from distinct breast cancer cell lines (4T1 and SKBR3) that express a marker that selectively interacts with retinoblastoma cells and were loaded with Dox, utilizing the cells’ endogenous loading machinery. In vitro, we observed that delivering Dox with both EVs increased cytotoxicity while dramatically lowering the dosage of the drug. Dox-loaded EVs, on the other hand, inhibited cancer cell growth by activating caspase-3/7. Direct interaction of EV membrane moieties with retinoblastoma cell surface receptors resulted in an effective drug delivery to cancer cells. Our findings emphasize the intriguing potential of EVs as optimum methods for delivering Dox to retinoblastoma. Full article
(This article belongs to the Special Issue Advances in Biomimetic Materials and Biomedical Devices)
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Review

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28 pages, 1162 KiB  
Review
Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease
by Adelle E. Hamilton and Ryan J. Gilbert
Bioengineering 2023, 10(2), 262; https://doi.org/10.3390/bioengineering10020262 - 16 Feb 2023
Cited by 10 | Viewed by 4513
Abstract
Curcumin, a bioactive phenol derived from turmeric, is an antioxidant, anti-inflammatory, and antibacterial molecule. Although curcumin exhibits beneficial effects in its innate form, it is highly hydrophobic, which leads to poor water solubility and, consequently, low bioavailability. The lack of bioavailability limits curcumin’s [...] Read more.
Curcumin, a bioactive phenol derived from turmeric, is an antioxidant, anti-inflammatory, and antibacterial molecule. Although curcumin exhibits beneficial effects in its innate form, it is highly hydrophobic, which leads to poor water solubility and, consequently, low bioavailability. The lack of bioavailability limits curcumin’s effectiveness as a treatment and restricts its use in clinical applications. Furthermore, to achieve beneficial, clinically relevant results, high doses of curcumin are required for systemic administration. Many researchers have utilized biomaterial carriers, including electrospun fibers, nanoparticles, hydrogels, and composite scaffolds, to overcome curcumin’s principle therapeutic limitation of low bioavailability. By using biomaterials to deliver curcumin directly to injury sites, researchers have harnessed the beneficial natural properties of curcumin while providing scaffolding to support tissue regeneration. This review will provide an in-depth overview of the literature that utilizes biomaterial delivery of curcumin for tissue regeneration in injury and disease models. Full article
(This article belongs to the Special Issue Advances in Biomimetic Materials and Biomedical Devices)
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