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Bioengineering
Special Issues
Nanoparticles in Drug Delivery: Present and Future Trends
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Nanoparticles in Drug Delivery: Present and Future Trends

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanobiotechnology and Biofabrication".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 13022

Special Issue Editors

Prof. Dr. Carmen S. R. Freire

E-Mail Website
Guest Editor
CICECO—Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: production and application of biogenic nanofibers (bacterial cellulose and protein fibrils); nanostructured biocomposites; bio-based materials for biomedical applications (wound healing, drug delivery and 3D-bioprinting); biocomposites and functional paper materials; chemical modification of (nano)cellulose fibers and other polysaccharides and their characterization and applications; chemistry of lignocellulosic materials (cellulose, wood, cork, etc.)
Special Issues, Collections and Topics in MDPI journals
Dr. Bárbara Leite Ferreira

E-Mail Website
Guest Editor
Aveiro Institute of Materials (CICECO), Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: materials (polymers, ceramics, composites) for biomedical applications; drug delivery nanosystems; metallodrugs with antitumoral, antidiabetic, and antibacterial properties
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, the great development of bioengineering and medical biotechnology has facilitated the design and production of nanoparticles exhibiting unique physicochemical and biological properties favorable for drug delivery applications. The key advantages of nanoparticles are (I) improved bioavailability by enhancing aqueous solubility, (II) increased half-life for clearance, and (III) targeting of therapeutic agents to its specific site of action. This results in concomitant reduction in the quantity of drugs required and dosage toxicity, enabling the safe delivery of toxic therapeutic drugs and protection of non-target tissues and cells from severe side effects. The main aim of this Special Issue is to focus on present and future developments of nanoparticles as drug delivery systems. Addressed topics include but are not limited to organic (synthetic, (bio)polymer-based, and lipid nanoparticles) and inorganic nanoparticles (gold, magnetic, silica nanoparticles, etc.) for the delivery of therapeutic agents, and nanoparticles for health applications in general.

It is our pleasure to invite you to submit a manuscript to this Special Issue. Full-length papers, short communications, and reviews are all welcome. We look forward to receiving your contributions.

Prof. Dr. Carmen Freire
Dr. Bárbara Leite Ferreira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (4 papers)

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Research

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15 pages, 9187 KiB  
Article
Effect of Citrate- and Gold-Stabilized Superparamagnetic Iron Oxide Nanoparticles on Head and Neck Tumor Cell Lines during Combination Therapy with Ionizing Radiation
by Christoph Schreiber, Tim Franzen, Laura Hildebrand, René Stein, Bernhard Friedrich, Rainer Tietze, Rainer Fietkau and Luitpold V. Distel
Bioengineering 2022, 9(12), 806; https://doi.org/10.3390/bioengineering9120806 - 15 Dec 2022
Cited by 2 | Viewed by 2124
Abstract
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. They are associated with alcohol and tobacco consumption, as well as infection with human papillomaviruses (HPV). Therapeutic options include radiochemotherapy, surgery or chemotherapy. Nanoparticles are becoming more and more [...] Read more.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. They are associated with alcohol and tobacco consumption, as well as infection with human papillomaviruses (HPV). Therapeutic options include radiochemotherapy, surgery or chemotherapy. Nanoparticles are becoming more and more important in medicine. They can be used diagnostically, but also therapeutically. In order to provide therapeutic alternatives in the treatment of HNSCC, the effect of citrate-coated superparamagnetic iron oxide nanoparticles (Citrate-SPIONs) and gold-coated superparamagnetic iron oxide nanoparticles (Au-SPIONs) in combination with ionizing irradiation (IR) on two HPV positive and two HPV negative HNSCC and healthy fibroblasts and keratinocytes cell lines were tested. Effects on apoptosis and necrosis were analyzed by using flow cytometry. Cell survival studies were performed with a colony formation assay. To better understand where the SPIONs interact, light microscopy images and immunofluorescence studies were performed. The HNSCC and healthy cell lines showed different responses to the investigated SPIONs. The cytotoxic effects of SPIONs, in combination with IR, are dependent on the type of SPIONs, the dose administered and the cell type treated. They are independent of HPV status. Reasons for the different cytotoxic effect are probably the different compositions of the SPIONs and the related different interaction of the SPIONs intracellularly and paramembranously, which lead to different strong formations of double strand breaks. Full article
(This article belongs to the Special Issue Nanoparticles in Drug Delivery: Present and Future Trends)
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Review

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23 pages, 4232 KiB  
Review
Silica-Based Nanomaterials for Diabetes Mellitus Treatment
by Diogo Marinheiro, Fátima Martel, Bárbara J. M. L. Ferreira and Ana L. Daniel-da-Silva
Bioengineering 2023, 10(1), 40; https://doi.org/10.3390/bioengineering10010040 - 29 Dec 2022
Cited by 8 | Viewed by 3326
Abstract
Diabetes mellitus, a chronic metabolic disease with an alarming global prevalence, is associated with several serious health threats, including cardiovascular diseases. Current diabetes treatments have several limitations and disadvantages, creating the need for new effective formulations to combat this disease and its associated [...] Read more.
Diabetes mellitus, a chronic metabolic disease with an alarming global prevalence, is associated with several serious health threats, including cardiovascular diseases. Current diabetes treatments have several limitations and disadvantages, creating the need for new effective formulations to combat this disease and its associated complications. This motivated the development of therapeutic strategies to overcome some of these limitations, such as low therapeutic drug bioavailability or poor compliance of patients with current therapeutic methodologies. Taking advantage of silica nanoparticle characteristics such as tuneable particle and pore size, surface chemistry and biocompatibility, silica-based nanocarriers have been developed with the potential to treat diabetes and regulate blood glucose concentration. This review discusses the main topics in the field, such as oral administration of insulin, glucose-responsive devices and innovative administration routes. Full article
(This article belongs to the Special Issue Nanoparticles in Drug Delivery: Present and Future Trends)
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21 pages, 1854 KiB  
Review
Polymeric Materials as Indispensable Tools to Fight RNA Viruses: SARS-CoV-2 and Influenza A
by Ariana C. F. Santos, Fátima Martel, Carmen S. R. Freire and Bárbara J. M. L. Ferreira
Bioengineering 2022, 9(12), 816; https://doi.org/10.3390/bioengineering9120816 - 18 Dec 2022
Viewed by 1787
Abstract
Towards the end of 2019 in Wuhan, suspicions of a new dangerous virus circulating in the air began to arise. It was the start of the world pandemic coronavirus disease 2019 (COVID-19). Since then, considerable research data and review papers about this virus [...] Read more.
Towards the end of 2019 in Wuhan, suspicions of a new dangerous virus circulating in the air began to arise. It was the start of the world pandemic coronavirus disease 2019 (COVID-19). Since then, considerable research data and review papers about this virus have been published. Hundreds of researchers have shared their work in order to achieve a better comprehension of this disease, all with the common goal of overcoming this pandemic. The coronavirus is structurally similar to influenza A. Both are RNA viruses and normally associated with comparable infection symptoms. In this review, different case studies targeting polymeric materials were appraised to highlight them as an indispensable tool to fight these RNA viruses. In particular, the main focus was how polymeric materials, and their versatile features could be applied in different stages of viral disease, i.e., in protection, detection and treatment. Full article
(This article belongs to the Special Issue Nanoparticles in Drug Delivery: Present and Future Trends)
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11 pages, 3087 KiB  
Review
Recent Advances of Calcium Carbonate Nanoparticles for Biomedical Applications
by Pengxuan Zhao, Yu Tian, Jia You, Xin Hu and Yani Liu
Bioengineering 2022, 9(11), 691; https://doi.org/10.3390/bioengineering9110691 - 15 Nov 2022
Cited by 29 | Viewed by 5022
Abstract
Calcium carbonate nanoparticles have been widely used in biomedicine due to their biocompatibility and biodegradability. Recently, calcium carbonate nanoparticles are largely integrated with imaging contrast and therapeutic agents for various imaging and therapeutic approaches. In this review, we first described the advantages and [...] Read more.
Calcium carbonate nanoparticles have been widely used in biomedicine due to their biocompatibility and biodegradability. Recently, calcium carbonate nanoparticles are largely integrated with imaging contrast and therapeutic agents for various imaging and therapeutic approaches. In this review, we first described the advantages and preparation methods of calcium carbonate nanoparticles, then the state-of-the-art progress of calcium carbonate nanoparticles in diagnosis, treatment and theranostics was summarized. Finally, we discussed the challenges and recommendations for future studies of the calcium carbonate nanoparticles. Full article
(This article belongs to the Special Issue Nanoparticles in Drug Delivery: Present and Future Trends)
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