Research Advancements in Oral Biology

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 451

Special Issue Editors


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Guest Editor
Department of Pharmacology in Dentistry, Faculty of Dental Medicine, University of Belgrade, Dr Subotica 1, 11 000 Belgrade, Serbia
Interests: oral diseases; oral cavity organ homeostasis; COVID-19; diabetes mellitus; application of artificial intelligence in medicine and dentistry
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Guest Editor
Laboratory for Radiobiology and Molecular Genetics, Department of Health and Environment, “VINČA” Institute of Nuclear Sciences-National Institute of the Republic of Serbia, University of Belgrade, 11351 Belgrade, Serbia
Interests: microRNA; oral; molecular genetics; cancer; bioinformatics

Special Issue Information

Dear Colleagues,

Oral biology has undergone enormous advancements in recent years, mainly driven by innovations in biotechnology, molecular biology, and artificial intelligence, which have not only expanded our understanding of oral diseases but also upgraded our therapeutic approaches such as tissue engineering and regenerative medicine. Advances in genomics and proteomics have provided insights into the mechanisms underlying oral diseases as well as the discovery of specific biomarkers, especially within salivary diagnostics, with the aims of improving oral disease detection and providing personalized treatments. The integration of artificial intelligence (AI) paves the way to more accurate and precise oral biology research and medical practice via the analysis of complex datasets and biomarkers, enabling earlier disease detection that is faster and more precise, as well as the prediction of oral disease progression or the likelihood of their treatment success.

This Special Issue aims to provide a comprehensive overview of the latest research trends and clinical innovations in oral biology, thereby encouraging articles which will focus on the innovations in genomics, proteomics, and metabolomics, tissue engineering for restoring and regenerating oral tissues, AI’s application in accelerating research and medical practice, as well as drug discovery in oral biology. Interdisciplinary research aimed at promoting discussions and fostering oral–systemic health research and collaborative practice is preferred. In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: genomics; proteomics; salivary diagnostics; artificial intelligence engagement; personalized medicine.

We look forward to receiving your contributions.

Prof. Dr. Jelena R. Roganović
Dr. Nina Petrović
Guest Editors

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Keywords

  • oral biology
  • oral tissue regeneration
  • artificial intelligence (AI) in dentistry
  • genomics and proteomics in dentistry
  • dental research
  • salivary diagnostics

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Published Papers (1 paper)

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Review

29 pages, 774 KiB  
Review
Murine Models in Oral Research: A Narrative Review of Experimental Approaches and Cardiovascular Implications
by Asmaa Elhaieg, Ahmed Farag, Ahmed S. Mandour, Miki Hirose, Ahmed Elfadadny and Ryou Tanaka
Biology 2025, 14(2), 127; https://doi.org/10.3390/biology14020127 - 26 Jan 2025
Viewed by 290
Abstract
Oral research using murine models spans a broad spectrum of studies, including investigations into oral infections such as periodontitis and peri-implantitis, wound healing, periodontal responses to orthodontic treatment, and occlusal overload. This review aims to provide a comprehensive overview of murine models employed [...] Read more.
Oral research using murine models spans a broad spectrum of studies, including investigations into oral infections such as periodontitis and peri-implantitis, wound healing, periodontal responses to orthodontic treatment, and occlusal overload. This review aims to provide a comprehensive overview of murine models employed in oral research, with a particular focus on their relevance in studying systemic implications, including cardiovascular diseases (CVDs). The objectives of this review are twofold: first, to highlight the diversity of experimental methods utilized in murine oral research, such as ligature placement, bacterial inoculation, surgical interventions, and mechanical manipulations; second, to explore how these models enhance our understanding of oral–systemic interactions. The findings demonstrate that murine models have significantly contributed to uncovering how oral conditions influence systemic health. Models of oral infections reveal pathways linking systemic inflammation, endothelial dysfunction, and atherogenesis, while studies on wound healing and mechanical stress offer valuable insights into periodontal tissue responses and regeneration under various conditions. These diverse findings underscore the versatility of murine models in addressing key questions across oral health research. By replicating human disease mechanisms, murine models serve as powerful tools for investigating the interplay between oral health and systemic diseases, including cardiovascular dysfunction. The insights gained from these models guide the development of integrated therapeutic approaches aimed at mitigating systemic inflammation and promoting periodontal regeneration. Full article
(This article belongs to the Special Issue Research Advancements in Oral Biology)
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