Advances in Omics Approaches for Understanding Metabolic Disorders: Environmental and Nutritional Perspectives

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 477

Special Issue Editor


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Guest Editor
Center for Computational Toxicology and Exposure, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Interests: omics approaches; advanced toxicity screening; human health risk assessment; environmental and nutritional factors; metabolic disorders; toxicology; biomarker discovery; stem cell biology

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue of Biology, titled “Advances in Omics Approaches for Understanding Metabolic Disorders: Environmental and Nutritional Perspectives”.

Metabolic disorders, including obesity, type 2 diabetes, and cardiovascular diseases, are complex conditions influenced by various factors, such as environmental exposures and nutritional influences. Both factors independently play significant roles in disrupting metabolic pathways and increasing the risk of disease. The combination of these influences can amplify their adverse effects, offering unique insights into their interplay. This Special Issue will focus on these critical topics, either individually or in combination, to advance our understanding of metabolic dysfunction and disease mechanisms.

We aim to highlight cutting-edge research leveraging omics technologies (e.g., transcriptomics, proteomics, and metabolomics) to explore the molecular mechanisms underlying metabolic disorders. In addition, we encourage studies addressing cumulative toxicity, co-exposures, and advanced methodologies for toxicity screening, which are particularly relevant in understanding the complex interactions between these factors.

Submissions to this Special Issue are welcome on themes including, but not limited to, the following:

  • Mechanistic insights into metabolic dysfunction across key tissues and systems;
  • Omics approaches to studying disrupted metabolic pathways;
  • Environmental exposures or nutritional factors contributing to metabolic disorders;
  • Co-exposure and cumulative toxicity as amplifiers of metabolic disruption.
  • High-throughput screening and computational modeling for metabolic toxicity;
  • Integration of omics data into a systems-level understanding of metabolic diseases;
  • Advances in NAMs and in vitro models for studying metabolic dysfunction.

This Special Issue aligns with Biology’s mission to advance knowledge in biological systems, offering a platform for research at the intersection of toxicology, nutrition, and systems biology. By exploring these critical areas, this collection will provide novel insights and actionable knowledge for addressing metabolic disorders and their underlying mechanisms.

We look forward to receiving your contributions to this exciting and pertinent Special Issue.

Dr. Yue Ge
Guest Editor

Manuscript Submission Information

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Keywords

  • metabolic disorders
  • environmental exposures
  • nutritional factors
  • omics technologies
  • co-exposures
  • cumulative toxicity
  • metabolic pathways
  • human health risk assessment
  • advanced in vitro models
  • systems toxicology

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Published Papers (1 paper)

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7 pages, 185 KiB  
Commentary
Integrating New Approach Methodologies to Address Environmental Pancreatic Toxicity and Metabolic Disorders
by Yue Ge
Biology 2025, 14(1), 85; https://doi.org/10.3390/biology14010085 - 17 Jan 2025
Viewed by 388
Abstract
Advancing our understanding of pancreatic toxicity and metabolic disorders caused by environmental exposures requires innovative approaches. The pancreas, a vital organ for glucose regulation, is increasingly recognized as a target of harm from environmental chemicals and dietary factors. Traditional toxicological methods, while foundational, [...] Read more.
Advancing our understanding of pancreatic toxicity and metabolic disorders caused by environmental exposures requires innovative approaches. The pancreas, a vital organ for glucose regulation, is increasingly recognized as a target of harm from environmental chemicals and dietary factors. Traditional toxicological methods, while foundational, often fail to address the mechanistic complexities of pancreatic dysfunction, particularly under real-world conditions involving multiple exposures. New Approach Methodologies (NAMs)—including high-throughput screening (HTS), OMICS technologies, computational modeling, and advanced in vitro systems—offer transformative tools to tackle these challenges. NAMs enable the identification of mechanistic pathways, improve testing efficiency, and reduce reliance on animal testing. This commentary explores the integration of NAMs into pancreatic toxicity screening, addresses critical gaps in evaluating the cumulative risks of chemical and dietary exposures, and proposes solutions for integrating the pancreas into toxicity screening through NAMs. By highlighting recent advancements and emphasizing their adoption in environmental toxicity assessment frameworks, this work demonstrates the potential of NAMs to revolutionize environmental health research, inspire interdisciplinary collaboration, and protect public health. Full article
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