Circular RNA Biology and Roles in Diseases
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 1885
Special Issue Editors
Interests: circRNAs; RNA biology; cardiovascular disease
Special Issue Information
Dear Colleagues,
Circular RNAs (circRNAs) are a class of endogenous, non-coding RNA molecules that contain single-stranded transcripts that can covalently construct circular closed structures. circRNAs are extensively expressed in the human body in tissue-disease and developmental-stage-specific manners and play a vital role in the pathogenesis and progression of human diseases. circRNAs can act as microRNA (miRNA) sponges, interact with RNA-binding proteins (RBPs), regulate gene transcription, and even directly regulate gene expression through coding proteins. The emergence of biological functions of circRNAs has brought a new perspective to our understanding of cellular physiology and disease pathogenesis. However, the mechanisms of circRNA biogenesis are still quite unclear, and further studies are needed on the regulation and functions of these molecules in healthy tissues and diseases.
The aim of this Special Issue is to provide an important overview of the relationship between the biology of circRNAs and diseases. With the rapid advancement of circRNA studies and RNA-related technologies, our knowledge of the relationship between circRNA and diseases is constantly evolving. Although there are still many unanswered questions regarding the biology of circular RNAs and the mechanisms governing their gene regulation, significant advances have been made in this field that have increased our knowledge of circRNAs.
This Special Issue aims to discuss the critical roles of circRNAs in the progression of different diseases, highlighting the underlying mechanisms of circRNAs. Additionally, the focus is on the biogenesis of circRNAs and uncovering central aspects of circRNA biogenesis and biology.
We look forward to receiving your contributions.
Dr. Nan Wu
Dr. Sema Misir
Guest Editors
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Keywords
- RNA biology
- diseases
- circRNAs
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