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Biology
Special Issues
Pathogenic Mechanisms of Hypertension and Neurodegenerative Disorders
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Pathogenic Mechanisms of Hypertension and Neurodegenerative Disorders

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 1050

Special Issue Editors

Prof. Dr. Yansheng Du

E-Mail Website
Guest Editor
Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Interests: neuronal injury disorders; neurodegeneration; neuroinflammation; pathogenic mechanisms; hypertension; adipose stem cells
Dr. Mingming Chen

E-Mail Website
Guest Editor
Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
Interests: neurodegeneration; induced pluripotent stem cells; hypertension; astrogliosis

Special Issue Information

Dear Colleagues,

Hypertension is estimated to affect 1.28 billion people globally (one-third of adults) and caused 10.8 million deaths in 2019 (ranking number of two in risk factors). The brain is a direct target of hypertension, and hypertension-induced brain damage may manifest as stroke, cerebrovascular abnormalities, encephalopathy, and dementia, including vascular dementia and Alzheimer’s disease. Studies on these two research areas highlight both the importance of hypertension in neurodegenerative disorders as well as some unanswered questions and controversies regarding hypertension in the context of neurodegenerative diseases. A deeper mechanistic understanding of the underlying pathogenic mechanisms as well as the exact relationship between hypertension and neurodegenerative disorders by using cutting-edge methods could facilitate the development of innovative therapies for hypertension-mediated neurodegenerative disorders.

This Special Issue welcomes both basic and translational research or review articles focusing on the pathogenic mechanisms underlying hypertension or neurodegenerative disorders. Potential topics include, but are not limited to, animal models, basic molecular and cellular signaling mechanisms, biomarkers, and novel therapeutic interventions targeting hypertension, cerebrovascular pathology, or neurodegenerative disorders.

Prof. Dr. Yansheng Du
Dr. Mingming Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurodegenerative diseases
  • hypertension
  • stroke
  • dementia
  • cerebral vasculature
  • hypoperfusion
  • inflammation
  • microglia
  • astrocytes
  • neurons

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Published Papers (1 paper)

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Research

12 pages, 1382 KiB  
Article
The Effects of Aldosterone on Hypertension-Associated Kidney Injury in a Tg-hAS Mouse Model
by Huiying Gu, Zhe Chen, Nicole Du, Sisi Yang, Yongqi Yu and Yansheng Du
Biology 2024, 13(12), 1084; https://doi.org/10.3390/biology13121084 - 22 Dec 2024
Viewed by 597
Abstract
Hypertension remains a global health challenge due to its high prevalence and association with premature morbidity and mortality. Aldosterone, a mineralocorticoid hormone, and its receptor, the mineralocorticoid receptor (MR), are highly implicated in hypertension pathogenesis. Aldosterone synthase is the sole enzyme responsible for [...] Read more.
Hypertension remains a global health challenge due to its high prevalence and association with premature morbidity and mortality. Aldosterone, a mineralocorticoid hormone, and its receptor, the mineralocorticoid receptor (MR), are highly implicated in hypertension pathogenesis. Aldosterone synthase is the sole enzyme responsible for producing aldosterone in humans. We established transgenic mice carrying the human aldosterone synthase gene (cyp11B2) and showed dramatically increased levels of aldosterone in female hemizygotes. High-salt diets persistently increased blood pressure in these mice, and salt-induced hypertension was significantly ameliorated by reducing aldosterone levels via an aldosterone synthase inhibitor or blocking MR via an MR inhibitor. Since both hypertension and hyperaldosteronism specifically induce chronic kidney disease, in this model, we demonstrated that chronic high-salt diets induced hypertension in this mouse line and resulted in kidney inflammation and injury. Both the aldosterone synthase inhibitor and the MR antagonist markedly blocked high-salt-diet-mediated kidney injury. Thus, this transgenic mouse line can be used to study the pathogenic mechanisms underlying aldosterone and its receptor and to screen therapeutic compounds for aldosterone-mediated hypertension and related complications, such as kidney disease, in humans. Full article
(This article belongs to the Special Issue Pathogenic Mechanisms of Hypertension and Neurodegenerative Disorders)
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