Recent Advances in Brain Vascular Diseases Management and Therapy 2.0
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2711
Special Issue Editor
Interests: aged animals models of cerebral ischemia; behavioral analysis; recording of EEG and various physiological parameters by telemetric measurements; MRI for small animals; immunohistochemical procedures; proteomics; genomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Brain plasticity allows for the continuous remodeling of the brain’s structure and function during aging and disease. Aging is accompanied by changes in blood vessel structure, leading to a decrease in blood flow to the peripheral organs. In the central nervous system, cerebral vascular aging can lead to a loss of the integrity of the blood-brain barrier, eventually resulting in cognitive and sensorimotor decline. One of the major of types of cognitive dysfunction due to chronic cerebral hypoperfusion is vascular cognitive impairment and degenerative processes that lead to dementia. Thus, some patients suffering from Alzheimer’s disease present with symptoms manifested by cortical and/or subcortical clinical symptoms that are related to the atheromatous vascular degeneration of the brain’s arteries.
Thus, comprehensive approaches need to be developed that address the multiple, interrelated mechanisms of brain aging. Attention is drawn to the importance of the maintenance of cerebromicrovascular health; the restoration of neuroendocrine balance; and the pressing need for funding more innovative research into the interactions between neuronal, neuroendocrine, inflammatory, and microvascular mechanisms in cognitive impairment and Alzheimer’s disease.
Old age in both humans and animals is associated with an enhanced susceptibility to stroke; aged animals recover poorly from brain injuries compared to young rodents. Stroke increases the risk of cognitive impairment and dementia and may contribute to the progression of Alzheimer's disease. Despite the initial hope that cell-based therapies may stimulate restorative processes in the ischemic brain, it is now recognized that aging processes may promote an unfavorable environment for such treatments.
During the past several years, there has been increasing interest in the role of human cerebrovasculature and the blood-brain barrier (BBB) as etiological factors contributing to the development of seizures and chronic epilepsy. Recently, much emphasis has been placed on dysregulated angiogenesis, BBB permeability, and epilepsy.
This Special Issue of Biomedicines will provide up-to-date information on different aspects of brain aging from the latest developments in the field of neurodegenerative disorders to cerebral microvascular mechanisms of cognitive decline. New avenues for research targeting cellular senescence, epigenetics, and endocrine mechanisms of brain aging are also discussed. Based on the current literature, it is clear that understanding brain aging and reducing the risk of neurological disease with age requires searching for mechanisms and treatment options beyond age-related changes in neuronal function. This Special Issue will also cover recent advances in brain vasculature in signaling pathways that can potentially protect cells, as well as treatment options for the maintenance of cerebromicrovascular functioning to prevent diseases associated with brain vasculature remodeling in response to aging and associated diseases and present new treatment options.
Prof. Dr. Aurel Popa-Wagner
Guest Editor
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Keywords
- aging
- vasculature
- cognition
- dementia
- stroke
- hemorrhagic stroke
- comorbidities
- epilepsy
- Alzheimer’s disease
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