New Therapeutic Tools to Combat Aging and Cerebrovascular Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 September 2024) | Viewed by 2716
Special Issue Editor
Interests: ageing; cerebrovascular diseases; cell therapies; gene therapy; behavioral recovery; genomics; proteomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Genetic conversion is a cutting-edge technique designed to modify the genetic structure of cells to produce desired physiological outcomes. This method encompasses DNA editing, gene expression modification, and the alteration of epigenetic marks that influence gene activation levels. The primary goal is to amend or substitute genes linked to aging and diseases, or to introduce beneficial genes that enhance health and longevity.
The authors’ contributions may include the following: (1) gene replacement (introducing new genes to supplant mutated or faulty ones); (2) CRISPR/Cas9 gene-editing technology; (3) epigenetic modifications; (4) manipulating DNA to modulate gene expression, which may include rejuvenating cells by resetting their “age”.
Applications aimed at reversing aging may also include (5) telomere extension to rejuvenate cells and potentially extend lifespan; (6) senescent cell clearance by eliminating old, dysfunctional cells to decrease inflammation and foster tissue regeneration; (7) sirtuin to boost cell function and promote longevity.
Additionally, genetic conversion can address vascular-related conditions by (8) fixing gene mutations that impair vascular integrity and function, affecting blood pressure and arterial health; (9) neuroprotection by introducing genes that produce protective factors to safeguard the brain against stroke and other cerebrovascular damages.
Researchers specializing in aging and cerebrovascular diseases are encouraged to contribute findings that explore these innovative strategies.
Prof. Dr. Aurel Popa-Wagner
Guest Editor
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Keywords
- cerebrovascular diseases
- stroke
- ischemic stroke
- ischemic stroke
- central nervous system (CNS)
- neurological disorders
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