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Biomedicines
Special Issues
Pollutants and Human Health: Focus on Molecular-Level Research
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Pollutants and Human Health: Focus on Molecular-Level Research

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1370

Special Issue Editor

Dr. Elisa Cairrao

E-Mail Website
Guest Editor
1. CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal
2 FCS—UBI, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal
Interests: endocrine disruptors; human exposome; pregnancy exposome; phthalates; flame retardants; UVB-filters; bisphenols; cardiovascular endocrinology; fetoplacental vasculature; vascular smooth muscle cells; neurovascular unit; hypertensive disorders in pregnancy; hypothyroidism; calcium and potassium channels; sex hormones; patch clamp
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The harmful impact of exposure to environmental toxicants is a subject of widespread concern due to human toxicological effects. The problem of environmental pollution is becoming a hot topic since these hazardous pollutants are present in the environment, and people can become exposed to them. Worryingly, many emerging organic pollutants are considered endocrine-disrupting chemicals and pose harmful effects in cardiovascular, endocrine, reproductive, and neurologic human systems. However, the molecular and cellular mechanisms that underly these effects are not yet fully clarified.

In this sense, this Special Issue intends to provide updated insights into the molecular pathways associated with pollutant-induced effects on human health. Therefore, we invite you to submit reviews and research papers on this issue. In vitro, in vivo, ex vivo, and in silico studies that help to explain the potential impacts of emerging contaminants on human health are welcome.

Dr. Elisa Cairrao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • environmental exposure
  • emerging pollutants
  • human and ecosystem health
  • environmental risk assessment
  • adverse outcome pathways
  • human risk assessment
  • endocrine-disrupting chemicals
  • cardiovascular endocrinology
  • neurovascular endocrinology
  • reproductive toxicology

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Published Papers (1 paper)

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Review

18 pages, 1786 KiB  
Review
Association between the Exposure to Phthalates and the Risk of Endometriosis: An Updated Review
by Bárbara Ribeiro, Melissa Mariana, Margarida Lorigo, Denise Oliani, Ana Cristina Ramalhinho and Elisa Cairrao
Biomedicines 2024, 12(8), 1932; https://doi.org/10.3390/biomedicines12081932 - 22 Aug 2024
Viewed by 1149
Abstract
Endometriosis is a chronic gynecological disease, primarily associated with pelvic pain and infertility, that affects approximately 10% of the women of reproductive age. Estrogen plays a central role in endometriosis, and there is growing evidence that endocrine disruptors, such as phthalates, may contribute [...] Read more.
Endometriosis is a chronic gynecological disease, primarily associated with pelvic pain and infertility, that affects approximately 10% of the women of reproductive age. Estrogen plays a central role in endometriosis, and there is growing evidence that endocrine disruptors, such as phthalates, may contribute to its development. This review aimed to determine whether there is a causal relationship between phthalate exposure and the development of endometriosis, as well as the possible effects of phthalates on fertility, by analyzing epidemiological data. After a literature search with a combination of specific terms on this topic, we found that although there are limitations to the current studies, there is a clear association between phthalate exposure and endometriosis. Phthalates can interfere with the cellular processes of the endometrium; specifically, they can bind to PPAR and ER-α and activate TGF-β, promoting different signaling cascades that regulate the expression of specific target genes. This may lead to inflammation, invasion, cytokine alteration, increased oxidative stress, and impaired cell viability and proliferation, culminating in endometriosis. Nevertheless, future research is important to curb the progression and development of endometriosis, and strategies for prevention, diagnosis, and treatment are a priority. In this regard, public policies and recommendations to reduce exposure to phthalates and other endocrine disruptors should be promptly implemented. Full article
(This article belongs to the Special Issue Pollutants and Human Health: Focus on Molecular-Level Research)
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