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Metabolites
Special Issues
Prevention, Diagnosis and Treatment of Metabolic and Hormone-Dependent Disorders
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Prevention, Diagnosis and Treatment of Metabolic and Hormone-Dependent Disorders

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Environmental Metabolomics".

Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 7315

Special Issue Editor

Dr. Elisa Cairrao

E-Mail Website
Guest Editor
1. CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal
2 FCS—UBI, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal
Interests: endocrine disruptors; human exposome; pregnancy exposome; phthalates; flame retardants; UVB-filters; bisphenols; cardiovascular endocrinology; fetoplacental vasculature; vascular smooth muscle cells; neurovascular unit; hypertensive disorders in pregnancy; hypothyroidism; calcium and potassium channels; sex hormones; patch clamp
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent evidence has associated exposure to endocrine disruptor chemicals (EDC) with metabolic and hormone-dependent disorders. One of the main concerns of the use of EDC is their ability to interfere with the endocrine system, by integrative and complex pathways of the hormones' mode of action. Different observations suggested that these environmental contaminants (bisphenol A, organochlorines, polybrominated flame retardants, perfluorinated substances, alkylphenols, phthalates, UVB-filters, pesticides, polycyclic aromatic hydrocarbons, alkylphenols) may be related with the development of cancer, diabetes, obesity, the metabolic syndrome, thyroid and fertility disorders. Furthermore, most of these compounds are ubiquitous in the environment, due to their use in everyday life products, like for example pesticides, plasticizers, solvents, and some household products including cleaning products, air fresheners, hair dyes, cosmetics, and sunscreens. Thus, it is pertinent to establish the association between human exposure to these compounds and the exponential increase in metabolic and hormone-dependent disorders, from prenatal to old age. This Special Issue intends to contribute to the clinical advancement for the prevention, diagnosis, and treatment of these pathologies associated with the lifestyle habits of modern populations.

Dr. Elisa Cairrao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endocrine-disrupting chemicals
  • cancer 
  • diabetes 
  • obesity 
  • fertility related diseases 
  • thyroid related diseases
  • clinical perspective 
  • human exposure 
  • adverse health outcomes

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Published Papers (3 papers)

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Research

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11 pages, 288 KiB  
Article
Cell Adhesion Molecules in Schizophrenia Patients with Metabolic Syndrome
by Anastasiia S. Boiko, Irina A. Mednova, Elena G. Kornetova, Arkadiy V. Semke, Nikolay A. Bokhan and Svetlana A. Ivanova
Metabolites 2023, 13(3), 376; https://doi.org/10.3390/metabo13030376 - 2 Mar 2023
Cited by 1 | Viewed by 1924
Abstract
Metabolic syndrome (MetS) is a common comorbidity of schizophrenia and significantly shortens life expectancy of the patients. Intercellular (ICAM), vascular (VCAM), and neural (NCAM) cell adhesion molecules (CAMs) mediate neuroinflammatory processes, and their soluble forms (e.g., sICAM) in plasma are present in parallel [...] Read more.
Metabolic syndrome (MetS) is a common comorbidity of schizophrenia and significantly shortens life expectancy of the patients. Intercellular (ICAM), vascular (VCAM), and neural (NCAM) cell adhesion molecules (CAMs) mediate neuroinflammatory processes, and their soluble forms (e.g., sICAM) in plasma are present in parallel with their cell-bound forms. In this study, their serum levels were examined in 211 white Siberian patients with paranoid schizophrenia (82 patients with and 129 without MetS according to the 2005 International Diabetes Federation criteria). Serum levels of CAMs were determined with Magpix and Luminex 200 (Luminex, Austin, TX, USA) using xMAP Technology. The level of sICAM-1 was significantly higher and that of sVCAM-1 significantly lower in patients with MetS compared to patients without MetS. Levels of NCAM did not differ between the groups. More pronounced Spearman’s correlations between CAMs, age, duration of schizophrenia, and body–mass index were observed among patients without MetS than among patients with MetS. Our results are consistent with MetS’s being associated with endothelial dysfunction along with other components of inflammation. Through these endothelial components of peripheral inflammatory processes, MetS might induce intracerebral neuroinflammatory changes, but further investigation is needed to confirm this. Full article
(This article belongs to the Special Issue Prevention, Diagnosis and Treatment of Metabolic and Hormone-Dependent Disorders)
13 pages, 292 KiB  
Article
The Association of Peptide Hormones with Glycemia, Dyslipidemia, and Obesity in Lebanese Individuals
by Murielle Abou-Samra, Koen Venema, Carole Ayoub Moubareck and Mirey Karavetian
Metabolites 2022, 12(11), 1051; https://doi.org/10.3390/metabo12111051 - 1 Nov 2022
Cited by 3 | Viewed by 1961
Abstract
Peptide-hormones, including pancreatic peptide-YY(PYY), glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK), insulin, and leptin function as satiety signals, while ghrelin promotes hunger. These hormones are also involved in glucose homeostasis and body-weight regulation. The aim of this cross-sectional analysis was to examine the association of [...] Read more.
Peptide-hormones, including pancreatic peptide-YY(PYY), glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK), insulin, and leptin function as satiety signals, while ghrelin promotes hunger. These hormones are also involved in glucose homeostasis and body-weight regulation. The aim of this cross-sectional analysis was to examine the association of these peptide-hormones with obesity-markers, insulin-resistance, and dyslipidemia (total-cholesterol (TC), low-density-lipoprotein-cholesterol (LDL-C), high-density-lipoprotein-cholesterol (HDL-C), triglyceride (TG)). Sixteen-obese (OB) adults and 21 normal-weight (NW) age-and gender-matched counterparts were recruited. OB-participants showed significantly higher levels of leptin, insulin, Homeostatic-Model Assessment of Insulin Resistance (HOMA-IR), and TG. NW participants had significantly higher levels of ghrelin. GLP-1 was positively correlated with insulin, HOMA-IR, and obesity-markers except percent body fat. Leptin was positively correlated with all markers (except glucose and dyslipidemia). PYY was positively correlated with BMI, insulin and HOMA-IR. Ghrelin was inversely correlated with all of the markers except glucose, TC, and LDL-C. In the regression analysis model, leptin was positively associated with obesity markers and insulin resistance. Our results indicate a significant difference in peptide hormones among OB and NW Lebanese individuals. Since there is controversial evidence regarding body-weight and peptide-hormones in the literature, this study highlights a step forward towards finding ethnic based strategies to treat obesity and its consequences. Full article
(This article belongs to the Special Issue Prevention, Diagnosis and Treatment of Metabolic and Hormone-Dependent Disorders)

Review

Jump to: Research

25 pages, 378 KiB  
Review
The Relationship between Phthalates and Diabetes: A Review
by Melissa Mariana and Elisa Cairrao
Metabolites 2023, 13(6), 746; https://doi.org/10.3390/metabo13060746 - 11 Jun 2023
Cited by 22 | Viewed by 2651
Abstract
Since the beginning of their production, in the 1930s, phthalates have been widely used in the plastics industry to provide durability and elasticity to polymers that would otherwise be rigid, or as solvents in hygiene and cosmetic products. Taking into account their wide [...] Read more.
Since the beginning of their production, in the 1930s, phthalates have been widely used in the plastics industry to provide durability and elasticity to polymers that would otherwise be rigid, or as solvents in hygiene and cosmetic products. Taking into account their wide range of applications, it is easy to understand why their use has been increasing over the years, making them ubiquitous in the environment. This way, all living organisms are easily exposed to these compounds, which have already been classified as endocrine disruptor compounds (EDC), affecting hormone homeostasis. Along with this increase in phthalate-containing products, the incidence of several metabolic diseases has also been rising, namely diabetes. That said, and considering that factors such as obesity and genetics are not enough to explain this substantial increase, it has been proposed that the exposure to environmental contaminants may also be a risk factor for diabetes. Thus, the aim of this work is to review whether there is an association between the exposure to phthalates and the development of the several forms of diabetes mellitus, during pregnancy, childhood, and adulthood. Full article
(This article belongs to the Special Issue Prevention, Diagnosis and Treatment of Metabolic and Hormone-Dependent Disorders)
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