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Biomimetics
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Biomimetic Approaches in Healthcare—Innovations Inspired by Nature: 2nd Edition
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Biomimetic Approaches in Healthcare—Innovations Inspired by Nature: 2nd Edition

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Development of Biomimetic Methodology".

Deadline for manuscript submissions: 30 May 2025 | Viewed by 740

Special Issue Editors

Prof. Dr. Vicente Javier Clemente-Suárez

E-Mail Website
Guest Editor
Faculty of Sports Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain
Interests: child stress; physiology; psychology; nutrition; health; disease; environment
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ana Isabel Beltrán-Velasco

E-Mail Website
Guest Editor
Psychology Department, Faculty of Life and Nature Sciences, Nebrija University, 28015 Madrid, Spain
Interests: behavioural psychology; psychological testing; psychological assessment; public health; neurodegenerative disease; psychological health; pathological mechanisms and therapeutic opportunities
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, entitled "Biomimetic Approaches in Healthcare—Innovations Inspired by Nature", explores the innovative intersection of healthcare and nature-inspired solutions. This collection of research articles delves into the emerging field of biomimetics, where scientists and healthcare professionals draw inspiration from the natural world to develop groundbreaking healthcare technologies and strategies. By mimicking biological processes, structures, and systems found in the environment, researchers aim to create more effective and sustainable solutions for healthcare challenges. This Special Issue features contributions that showcase how biomimetic approaches are revolutionizing medical diagnostics, treatment modalities, and healthcare practices. From bio-inspired materials for regenerative medicine to nature-inspired algorithms for healthcare data analysis, this Special Issue highlights the diverse applications of biomimetics in improving healthcare outcomes.

Prof. Dr. Vicente Javier Clemente-Suárez
Prof. Dr. Ana Isabel Beltrán-Velasco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomimetics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomimetics
  • healthcare innovations
  • nature-inspired solutions
  • medical diagnostics
  • regenerative medicine
  • bio-inspired materials
  • healthcare data analysis
  • natural algorithms
  • biologically inspired technology
  • sustainable healthcare

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Published Papers (1 paper)

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Research

28 pages, 7444 KiB  
Article
Exploring the Potential of Biomimetic Peptides in Targeting Fibrillar and Filamentous Alpha-Synuclein—An In Silico and Experimental Approach to Parkinson’s Disease
by Sophia A. Frantzeskos, Mary A. Biggs and Ipsita A. Banerjee
Biomimetics 2024, 9(11), 705; https://doi.org/10.3390/biomimetics9110705 - 18 Nov 2024
Viewed by 619
Abstract
Alpha-synuclein (ASyn) is a protein that is known to play a critical role in Parkinson’s disease (PD) due to its propensity for misfolding and aggregation. Furthermore, this process leads to oxidative stress and the formation of free radicals that cause neuronal damage. In [...] Read more.
Alpha-synuclein (ASyn) is a protein that is known to play a critical role in Parkinson’s disease (PD) due to its propensity for misfolding and aggregation. Furthermore, this process leads to oxidative stress and the formation of free radicals that cause neuronal damage. In this study, we have utilized a biomimetic approach to design new peptides derived from marine natural resources. The peptides were designed using a peptide scrambling approach where antioxidant moieties were combined with fibrillary inhibition motifs in order to design peptides that would have a dual targeting effect on ASyn misfolding. Of the 20 designed peptides, 12 were selected for examining binding interactions through molecular docking and molecular dynamics approaches, which revealed that the peptides were binding to the pre-NAC and NAC (non-amyloid component) domain residues such as Tyr39, Asn65, Gly86, and Ala85, among others. Because ASyn filaments derived from Lewy body dementia (LBD) have a different secondary structure compared to pathogenic ASyn fibrils, both forms were tested computationally. Five of those peptides were utilized for laboratory validation based on those results. The binding interactions with fibrils were confirmed using surface plasmon resonance studies, where EQALMPWIWYWKDPNGS, PYYYWKDPNGS, and PYYYWKELAQM showed higher binding. Secondary structural analyses revealed their ability to induce conformational changes in ASyn fibrils. Additionally, PYYYWKDPNGS and PYYYWKELAQM also demonstrated antioxidant properties. This study provides insight into the binding interactions of varying forms of ASyn implicated in PD. The peptides may be further investigated for mitigating fibrillation at the cellular level and may have the potential to target ASyn. Full article
(This article belongs to the Special Issue Biomimetic Approaches in Healthcare—Innovations Inspired by Nature: 2nd Edition)
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