Properties and Functions of Endometrial Stromal Cells

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Reproduction".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1265

Special Issue Editors


E-Mail Website
Guest Editor
School of Pharmaceutical Science, Ohu University, Fukushima 963-8611, Japan
Interests: placentation; implantation; endogenous retrovirus; gene expression; transfection; cell culture; gene regulation; PCR; DNA; cloning

E-Mail Website
Guest Editor
Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Interests: phosphorylation; signaling; endocrinology; proteins; p53; cell differentiation; apoptosis; protein kinases; signaling pathways; reproductive endocrinology

Special Issue Information

Dear Colleagues,

The endometrium is the reproductive tissue lining the uterus and undergoes extensive cyclic growth, regeneration, differentiation, and shedding throughout the menstrual cycle in response to steroid hormones. Endometrium abnormalities may be associated with repeated embryonic implantation failure, recurrent spontaneous abortions, and other physiological features contributing to female infertility. We hope that this Special Issue, titled "Properties and Functions of Endometrial Stromal Cells", will serve as a stepping stone to propose solutions for the abnormalities resulting from endometrial dysfunction in humans. This Special Issue welcomes your contributions in the form of original articles, reviews, or perspective articles on any aspect of recent advances in reproduction.

Dr. Toshihiro Sakurai
Dr. Mikihiro Yoshie
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometrium
  • endometriosis
  • molecular reproduction
  • implantation
  • decidualization
  • placentation
  • inflammation
  • reproductive endocrinology
  • assisted reproductive technology
  • molecular reproductive biology

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

11 pages, 1974 KiB  
Article
Decidualized Endometrial Stromal Cells Promote Mitochondrial Beta-Oxidation to Produce the Octanoic Acid Required for Implantation
by Yumi Mizuno, Shunsuke Tamaru, Hideno Tochigi, Tomomi Sato, Miyuko Kishi, Akira Ohtake, Osamu Ishihara and Takeshi Kajihara
Biomolecules 2024, 14(8), 1014; https://doi.org/10.3390/biom14081014 - 16 Aug 2024
Viewed by 944
Abstract
Decidualization denotes the morphological and biological differentiating process of human endometrial stromal cells (HESCs). Fatty acid pathways are critical for endometrial decidualization. However, the participation of fatty acids as an energy source and their role in endometrial decidualization have received little attention. To [...] Read more.
Decidualization denotes the morphological and biological differentiating process of human endometrial stromal cells (HESCs). Fatty acid pathways are critical for endometrial decidualization. However, the participation of fatty acids as an energy source and their role in endometrial decidualization have received little attention. To identify fatty acids and clarify their role in decidualization, we comprehensively evaluated free fatty acid profiles using liquid chromatography/Fourier transform mass spectrometry (LC/FT-MS). LC/FT-MS analysis detected 26 kinds of fatty acids in the culture medium of decidualized or un-decidualized HESCs. Only the production of octanoic acid, which is an essential energy source for embryonic development, was increased upon decidualization. The expressions of genes related to octanoic acid metabolism including ACADL, ACADM, and ACADS; genes encoding proteins catalyzing the first step of mitochondrial fatty acid beta-oxidation; and ACSL5 and ACSM5; genes encoding fatty acid synthesis proteins were significantly altered upon decidualization. These results suggest that decidualization promotes lipid metabolism, implying that decidualized HESCs require energy metabolism of the mitochondria in embryo implantation. Full article
(This article belongs to the Special Issue Properties and Functions of Endometrial Stromal Cells)
Show Figures

Figure 1

Back to TopTop