Human Gut Microbiome and Diet in Health and Diseases: 2nd Edition

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (15 December 2024) | Viewed by 1721

Special Issue Editor


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Guest Editor
Discipline of Pharmacology, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
Interests: clinical epidemiology; the human microbiome; probiotics and prebiotics and mood disorders; cellular redox potential and pro-oxidant signaling systems
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Special Issue Information

Dear Colleagues,

Following a very successful first edition, we are pleased to announce the launch of a second edition of a Special Issue on the “Human Gut Microbiome and Diet in Health and Diseases”.

Prudent dietary practices and quality are important lifestyle factors concordant with human health. The intestines are the largest interface between the internal and external environment. Subsequently, the gastrointestinal tract harbors the largest biomass and concentration of bacteria. Additionally, resident in the intestines is an extensive mucosal immune and host immuno-modulation network, as well as a nutrient metabolism site that maintains the integrity of the gut architecture and microbiome, facilitating control of pathobiont influences. The inter-relationships between dietary practices, the gut microbiome and keeping local mucosal immunity activities in equilibrium are critical signals for health maintenance and longevity.

Dr. Luis Vitetta
Guest Editor

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Keywords

  • gut microbiome
  • microbiota
  • nutrition
  • functional foods
  • mucosal immunity
  • dysbiosis

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Published Papers (1 paper)

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Research

16 pages, 3058 KiB  
Article
Gut Microbiome Dysbiosis in Patients with Pemphigus and Correlation with Pathogenic Autoantibodies
by Si-Zhe Li, Qing-Yang Wu, Yue Fan, Feng Guo, Xiao-Min Hu and Ya-Gang Zuo
Biomolecules 2024, 14(7), 880; https://doi.org/10.3390/biom14070880 - 22 Jul 2024
Cited by 1 | Viewed by 1307
Abstract
Background: Pemphigus is a group of potentially life-threatening autoimmune bullous diseases induced by pathogenic autoantibodies binding to the surface of epidermal cells. The role of the gut microbiota (GM) has been described in various autoimmune diseases. However, the impact of the GM on [...] Read more.
Background: Pemphigus is a group of potentially life-threatening autoimmune bullous diseases induced by pathogenic autoantibodies binding to the surface of epidermal cells. The role of the gut microbiota (GM) has been described in various autoimmune diseases. However, the impact of the GM on pemphigus is less understood. This study aimed to investigate whether there was alterations in the composition and function of the GM in pemphigus patients compared to healthy controls (HCs). Methods: Fecal samples were collected from 20 patients with active pemphigus (AP), 11 patients with remission pemphigus (PR), and 47 HCs. To sequence the fecal samples, 16S rRNA was applied, and bioinformatic analyses were performed. Results: We found differences in the abundance of certain bacterial taxa among the three groups. At the family level, the abundance of Prevotellaceae and Coriobacteriaceae positively correlated with pathogenic autoantibodies. At the genus level, the abundance of Klebsiella, Akkermansia, Bifidobacterium, Collinsella, Gemmiger, and Prevotella positively correlated with pathogenic autoantibodies. Meanwhile, the abundance of Veillonella and Clostridium_XlVa negatively correlated with pathogenic autoantibodies. A BugBase analysis revealed that the sum of potentially pathogenic bacteria was elevated in the AP group in comparison to the PR group. Additionally, the proportion of Gram-negative bacteria in the PR group was statistically significantly lower in comparison to the HC group. Conclusion: The differences in GM composition among the three groups, and the correlation between certain bacterial taxa and pathogenic autoantibodies of pemphigus, support a linkage between the GM and pemphigus. Full article
(This article belongs to the Special Issue Human Gut Microbiome and Diet in Health and Diseases: 2nd Edition)
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