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Biomolecules
Special Issues
The Role of Non-Coding RNAs in Health and Disease
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The Role of Non-Coding RNAs in Health and Disease

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1058

Special Issue Editor

Dr. Narasimman Gurusamy

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, 3200 South University Drive, Fort Lauderdale, FL 33328, USA
Interests: non-coding RNA
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Non-coding RNAs have emerged as pivotal molecular regulators in numerous biological processes, fundamentally altering our understanding of the complexities within the central dogma of biology. This Special Issue, “Non-Coding RNAs in Health and Disease”, aims to explore the multifaceted roles of non-coding RNAs, encompassing microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and others, in orchestrating cellular functions, disease progression, and the maintenance of health. The collection of articles, reviews, and research papers presented in this issue delves into the latest discoveries and innovative approaches in non-coding RNA research, highlighting their significance in gene expression regulation, epigenetic modifications, and their potential as therapeutic targets and diagnostic biomarkers.

This Special Issue will provide insightful analyses on the mechanisms by which non-coding RNAs influence disease pathogenesis, including cancer, neurodegenerative disorders, cardiovascular diseases, and more, offering a comprehensive overview of the current state of knowledge in the field. Additionally, this issue will explore the therapeutic potential of non-coding RNAs, examining the challenges and opportunities in harnessing these molecules for clinical applications. By bridging fundamental research and clinical practice, this Special Issue aims to accelerate the translation of non-coding RNA research into tangible health benefits, underscoring the importance of non-coding RNAs in the intricate landscape of health and disease.

Dr. Narasimman Gurusamy
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • non-coding RNA
  • microRNA (miRNA)
  • long noncoding RNA (lncRNA)
  • circular RNA (circRNA)
  • gene expression regulation
  • epigenetic modifications

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Published Papers (1 paper)

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16 pages, 3195 KiB  
Article
Transcriptomic-Based Identification of miR-125a Novel Targets in Human Hepatocarcinoma Cells
by Ilenia De Leo, Nicola Mosca, Mariaceleste Pezzullo, Danila Valletta, Francesco Manfrevola, Vincenza Grazia Mele, Rosanna Chianese, Aniello Russo and Nicoletta Potenza
Biomolecules 2025, 15(1), 144; https://doi.org/10.3390/biom15010144 - 18 Jan 2025
Viewed by 537
Abstract
Hepatocellular carcinoma (HCC) is among the most aggressive and lethal human tumors. Many functional studies have demonstrated the role of non-coding RNAs (ncRNA), particularly microRNAs (miRNA), in the regulation of hepatocarcinogenesis driving pathways. MiR-125a-5p (miR-125a) has been consistently reported as an oncosuppressive miRNA, [...] Read more.
Hepatocellular carcinoma (HCC) is among the most aggressive and lethal human tumors. Many functional studies have demonstrated the role of non-coding RNAs (ncRNA), particularly microRNAs (miRNA), in the regulation of hepatocarcinogenesis driving pathways. MiR-125a-5p (miR-125a) has been consistently reported as an oncosuppressive miRNA, as demonstrated in vivo and in vitro. However, its HCC relevant targets and molecular mechanisms are still largely unknown. Here, a genome-wide perspective of the whole miR-125a targetome has been achieved. In particular, two different HCC cell lines were subjected to a miRNA boosting by mimic transfections, and consequently many genes were de-regulated, as observed by a transcriptomic approach. The merging of down-regulated genes with results from bioinformatic predictive tools yielded a number of candidate direct targets that were further experimentally validated by luciferase-based reporter assays. Different novel targets were found, in particular ARID3A, CCNJ, LIPA, NR6A1, and NUP210, oncogenes in various tumors and here also related to HCC through miR-125a regulation. The RNA interactions investigated in this work could pave the way to piece together the RNA regulatory networks governed by the miRNA impacting on hepatocarcinogenesis, and be exploited in the future for identifying novel biomarkers and therapeutic targets in HCC. Full article
(This article belongs to the Special Issue The Role of Non-Coding RNAs in Health and Disease)
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