Recent Developments in Biophysical Studies of Cell Membranes: Second Edition

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biophysics".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 747

Special Issue Editor


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Guest Editor
Oak Ridge National Laboratory, Neutron Scattering Division, Oak Ridge, TN 37831, USA
Interests: membrane biophysics; model membranes; biomembranes; lipid bilayers; small-angle neutron scattering; peptide interactions with membranes
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Special Issue Information

Dear Colleagues,

Following a very successful first edition, we are pleased to announce that we are accepting submissions for a second edition of a Special Issue on “Recent Developments in Biophysical Studies of Cell Membranes”.

The composition, structure, function and physical properties of cellular membrane continue to attract the attention of researchers. It is an incredibly challenging, complex system to study, being made of a diverse array of lipids, proteins and carbohydrates that varies between different kinds of cells. This complexity gives rise to a highly heterogenous structure that is vital for its function. The creative application of biophysical techniques has produced considerable advances in our understanding of the cellular membrane. However, a great deal remains to be learned about it. In this second edition of the Special Issue, articles describing the studies of cellular membranes, as well as model membranes, performed using a variety of biophysical characterization techniques will be collected that highlight advances made in our understanding about the complexity of cellular membranes and their constituents. Review and original research manuscripts presenting the biophysical studies of cellular membranes and of model cell membranes are welcome as contributions to this Special Issue.

Dr. William T. Heller
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • membrane biophysics
  • cell membranes
  • model cell membranes

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Published Papers (1 paper)

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Research

15 pages, 4295 KiB  
Article
Local Stress in Cylindrically Curved Lipid Membrane: Insights into Local Versus Global Lateral Fluidity Models
by Konstantin V. Pinigin
Biomolecules 2024, 14(11), 1471; https://doi.org/10.3390/biom14111471 - 19 Nov 2024
Viewed by 373
Abstract
Lipid membranes, which are fundamental to cellular function, undergo various mechanical deformations. Accurate modeling of these processes necessitates a thorough understanding of membrane elasticity. The lateral shear modulus, a critical parameter describing membrane resistance to lateral stresses, remains elusive due to the membrane’s [...] Read more.
Lipid membranes, which are fundamental to cellular function, undergo various mechanical deformations. Accurate modeling of these processes necessitates a thorough understanding of membrane elasticity. The lateral shear modulus, a critical parameter describing membrane resistance to lateral stresses, remains elusive due to the membrane’s fluid nature. Two contrasting hypotheses, local fluidity and global fluidity, have been proposed. While the former suggests a zero local lateral shear modulus anywhere within lipid monolayers, the latter posits that only the integral of this modulus over the monolayer thickness vanishes. These differing models lead to distinct estimations of other elastic moduli and affect the modeling of biological processes, such as membrane fusion/fission and membrane-mediated interactions. Notably, they predict distinct local stress distributions in cylindrically curved membranes. The local fluidity model proposes isotropic local lateral stress, whereas the global fluidity model predicts anisotropy due to anisotropic local lateral stretching of lipid monolayers. Using molecular dynamics simulations, this study directly investigates these models by analyzing local stress in a cylindrically curved membrane. The results conclusively demonstrate the existence of static local lateral shear stress and anisotropy in local lateral stress within the monolayers of the cylindrical membrane, strongly supporting the global fluidity model. These findings have significant implications for the calculation of surface elastic moduli and offer novel insights into the fundamental principles governing lipid membrane elasticity. Full article
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