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Biomolecules
Special Issues
Fungal Metabolism—Enzymes and Bioactive Compounds II
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Fungal Metabolism—Enzymes and Bioactive Compounds II

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 10597

Special Issue Editors

Prof. Dr. Grzegorz Janusz

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Guest Editor
Department of Biochemistry and Biotechnology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19 Street, 20-033 Lublin, Poland
Interests: wood degradation; fungal enzymes; fungal genetics; light influence on microorganisms metabolism; biotechnology
Special Issues, Collections and Topics in MDPI journals
Dr. Anna Pawlik

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Guest Editor
Department of Biochemistry and Biotechnology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Lublin, Poland
Interests: laccase; wood degradation; microbiology; genomics; phylogenetics; fungal enzymes; light; enzymes in biotechnology; bioremediation
Special Issues, Collections and Topics in MDPI journals
Dr. Daniel Kracher

E-Mail Website
Guest Editor
Institute of Molecular Biotechnology, Graz University of Technology, 8010 Graz, Austria
Interests: biomass degradation; second-generation biofuels; cellulases; redox enzymes; biocatalysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of a second edition of a Special Issue on the “Fungal Metabolism—Enzymes and Bioactive Compounds”.

In recent years, the rapid development of different biotechnological areas has had a tremendous impact on our society. A growing number of research papers not only allows scientists to better understand the biology of microorganisms, but also to elucidate new solutions that are important for human health, nutrition, environment, and other activities. So-called “microbial cell factories” were already in use thousands of years ago for alcoholic fermentation or as a source of antibiotics without knowing their real nature and composition. At present, we better understand how to use whole microbial cells, how to isolate bioactive compounds, including enzymes, or even how to manipulate their genes to improve efficiency. The proposed Special Issue embraces all fungal products with importance in the field of biotechnology and shall highlight possible areas of future development. At the same time, any research or review paper contributing significantly to a better understanding of fungal metabolism, especially by “-omics” techniques, is highly welcome.

We look forward to receiving your contribution to give greater value to the present project.

Prof. Dr. Grzegorz Janusz
Dr. Anna Pawlik
Dr. Daniel Kracher
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • enzymes
  • fungi
  • bioactive compounds
  • medicinal mushrooms
  • endopolysaccharides
  • biotechnology

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Related Special Issue

Published Papers (2 papers)

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Review

68 pages, 13251 KiB  
Review
A Review of Ganoderma Triterpenoids and Their Bioactivities
by Mahesh C. A. Galappaththi, Nimesha M. Patabendige, Bhagya M. Premarathne, Kalani K. Hapuarachchi, Saowaluck Tibpromma, Dong-Qin Dai, Nakarin Suwannarach, Sylvie Rapior and Samantha C. Karunarathna
Biomolecules 2023, 13(1), 24; https://doi.org/10.3390/biom13010024 - 22 Dec 2022
Cited by 65 | Viewed by 6999
Abstract
For centuries, Ganoderma has been used as a traditional medicine in Asian countries to prevent and treat various diseases. Numerous publications are stating that Ganoderma species have a variety of beneficial medicinal properties, and investigations on different metabolic regulations of Ganoderma species, extracts [...] Read more.
For centuries, Ganoderma has been used as a traditional medicine in Asian countries to prevent and treat various diseases. Numerous publications are stating that Ganoderma species have a variety of beneficial medicinal properties, and investigations on different metabolic regulations of Ganoderma species, extracts or isolated compounds have been performed both in vitro and in vivo. However, it has frequently been questioned whether Ganoderma is simply a dietary supplement for health or just a useful “medication” for restorative purposes. More than 600 chemical compounds including alkaloids, meroterpenoids, nucleobases, nucleosides, polysaccharides, proteins, steroids and triterpenes were extracted and identified from Ganoderma, with triterpenes serving as the primary components. In recent years, Ganoderma triterpenes and other small molecular constituents have aroused the interest of chemists and pharmacologists. Meanwhile, considering the significance of the triterpene constituents in the development of new drugs, this review describes 495 compounds from 25 Ganoderma species published between 1984 and 2022, commenting on their source, biosynthetic pathway, identification, biological activities and biosynthesis, together with applications of advanced analytical techniques to the characterization of Ganoderma triterpenoids. Full article
(This article belongs to the Special Issue Fungal Metabolism—Enzymes and Bioactive Compounds II)
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26 pages, 2182 KiB  
Review
Current Challenges for Biological Treatment of Pharmaceutical-Based Contaminants with Oxidoreductase Enzymes: Immobilization Processes, Real Aqueous Matrices and Hybrid Techniques
by Helena Sá, Michele Michelin, Teresa Tavares and Bruna Silva
Biomolecules 2022, 12(10), 1489; https://doi.org/10.3390/biom12101489 - 15 Oct 2022
Cited by 14 | Viewed by 2734
Abstract
The worldwide access to pharmaceuticals and their continuous release into the environment have raised a serious global concern. Pharmaceuticals remain active even at low concentrations, therefore their occurrence in waterbodies may lead to successive deterioration of water quality with adverse impacts on the [...] Read more.
The worldwide access to pharmaceuticals and their continuous release into the environment have raised a serious global concern. Pharmaceuticals remain active even at low concentrations, therefore their occurrence in waterbodies may lead to successive deterioration of water quality with adverse impacts on the ecosystem and human health. To address this challenge, there is currently an evolving trend toward the search for effective methods to ensure efficient purification of both drinking water and wastewater. Biocatalytic transformation of pharmaceuticals using oxidoreductase enzymes, such as peroxidase and laccase, is a promising environmentally friendly solution for water treatment, where fungal species have been used as preferred producers due to their ligninolytic enzymatic systems. Enzyme-catalyzed degradation can transform micropollutants into more bioavailable or even innocuous products. Enzyme immobilization on a carrier generally increases its stability and catalytic performance, allowing its reuse, being a promising approach to ensure applicability to an industrial scale process. Moreover, coupling biocatalytic processes to other treatment technologies have been revealed to be an effective approach to achieve the complete removal of pharmaceuticals. This review updates the state-of-the-art of the application of oxidoreductases enzymes, namely laccase, to degrade pharmaceuticals from spiked water and real wastewater. Moreover, the advances concerning the techniques used for enzyme immobilization, the operation in bioreactors, the use of redox mediators, the application of hybrid techniques, as well as the discussion of transformation mechanisms and ending toxicity, are addressed. Full article
(This article belongs to the Special Issue Fungal Metabolism—Enzymes and Bioactive Compounds II)
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