Immunomics: From Molecular Studies to Preclinical Trials

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Bioinformatics and Systems Biology".

Deadline for manuscript submissions: closed (15 May 2024) | Viewed by 961

Special Issue Editors


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Guest Editor
Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria
Interests: plastic surgery; microsurgery; immunology

E-Mail Website
Guest Editor
Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria
Interests: genetics; genomics; epigenetics; chromatin; metabolomics; proteomics; immunology

Special Issue Information

Dear Colleagues,

Integrating cutting-edge research data into clinical decisions can lead to the identification of complex and unique molecular features.

The use of genomic and proteomic technologies to study immune system regulation and response to pathogens allows scientists a visualization of biological networks and gene and/or protein interactions to help better understand how the immune system functions and how it is regulated.

The focus of this Special Issue of Biomolecules will be on the most recent advances related to the exploitation of genome/proteome and metabolome-wide studies and matched targeted therapy/immunotherapy deployment in patients. Recent advances in the development, refinement, and discovery of individual genes and molecules, high-throughput, high-resolution omics technologies combined with sophisticated computational modeling and machine-learning approaches in clinical trials will be addressed.

Discussion on using human patient samples, the synchronization of the scientific process in the clinical routine and presentation of novel approaches to complement standard immunological methods with new insights into immune-system dynamics, along with the integration of OMICS analyses in precision medicine, will be encouraged in this context.

Finally, an overview of recent rapid biotechnological breakthroughs; genomic profiling; and transcriptomic, immunomic, and proteomic interrogations that have led to the identification of complex and unique molecular features and therapy optimization in this field will be included.

Research and review articles presenting novelties or overviews, respectively, are welcome.

Dr. Dolores Wolfram
Dr. Ines Schoberleitner
Guest Editors

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Keywords

  • immunomics
  • immunology
  • inflammation
  • genomics
  • transcriptomics
  • proteomics
  • metabolomics
  • immunome
  • immunoprofile
  • immunophenotype
  • vaccines
  • vaccine design
  • vaccine development regulatory networks
  • antigen discovery
  • complex pathogens

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Published Papers (1 paper)

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Review

34 pages, 3595 KiB  
Review
Unraveling the Immune Web: Advances in SMI Capsular Fibrosis from Molecular Insights to Preclinical Breakthroughs
by Ines Schoberleitner, Klaus Faserl, Michaela Lackner, Débora C. Coraça-Huber, Angela Augustin, Anja Imsirovic, Stephan Sigl and Dolores Wolfram
Biomolecules 2024, 14(11), 1433; https://doi.org/10.3390/biom14111433 - 11 Nov 2024
Viewed by 518
Abstract
Breast implant surgery has evolved significantly, yet challenges such as capsular contracture remain a persistent concern. This review presents an in-depth analysis of recent advancements in understanding the immune mechanisms and clinical implications associated with silicone mammary implants (SMIs). The article systematically examines [...] Read more.
Breast implant surgery has evolved significantly, yet challenges such as capsular contracture remain a persistent concern. This review presents an in-depth analysis of recent advancements in understanding the immune mechanisms and clinical implications associated with silicone mammary implants (SMIs). The article systematically examines the complex interplay between immune responses and capsular fibrosis, emphasizing the pathophysiological mechanisms of inflammation in the etiology of this fibrotic response. It discusses innovations in biomaterial science, including the development of novel anti-biofilm coatings and immunomodulatory surfaces designed to enhance implant integration and minimize complications. Emphasis is placed on personalized risk assessment strategies, leveraging molecular insights to tailor interventions and improve patient outcomes. Emerging therapeutic targets, advancements in surgical techniques, and the refinement of post-operative care are also explored. Despite notable progress, challenges such as the variability in immune responses, the long-term efficacy of new interventions, and ethical considerations remain. Future research directions are identified, focusing on personalized medicine, advanced biomaterials, and bridging preclinical findings with clinical applications. As we advance from bench to bedside, this review illuminates the path forward, where interdisciplinary collaboration and continued inquiry weave together to enhance the art and science of breast implant surgery, transforming patient care into a realm of precision and excellence. Full article
(This article belongs to the Special Issue Immunomics: From Molecular Studies to Preclinical Trials)
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