Novel Applications and Mechanism of Proteinase Inhibitors
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Proteins".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 10139
Special Issue Editor
Interests: functions and applications of alpha 1 antitrypsin (AAT) and SERPIN; development of novel treatment for autoimmune and inflammatory diseases; gene therapy using recombinant adeno-associated viral vectors (rAAV)
Special Issue Information
Dear Colleagues,
Balanced activities of proteinases and their inhibitors are critical in many biological processes to maintain a healthy condition. Overreactive proteinases are often involved in the pathogenesis of human diseases, including autoimmune, inflammatory and infectious diseases, as well as cancer. Therefore, targeting proteinase by synthetic or native proteinase inhibitors has therapeutic potential for the treatment of human diseases. In addition to the complexity of proteinase functions, the functions and applications of proteinase inhibitors remain elusive. Recent studies identified new proteinase inhibitors and revealed new mechanisms of proteinase inhibition. This Special Issue aims to publish recent findings that advance the therapeutic applications and the functional mechanism(s) of proteinase inhibitors.
Dr. Sihong Song
Guest Editor
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Keywords
- proteinase inhibitor
- serine proteinase inhibitor (SERPIN)
- tissue damage
- autoimmune disease
- inflammatory disease
- cancer
- computationally designed drugs
- drug screening
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