Dietary Phytochemicals - Mediated Cellular Signalling, Epigenetics/Epigenomics and Cancer Chemoprevention
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 2807
Special Issue Editors
Interests: anti-cancer drugs; signaling pathways; microRNAs; prognostic/diagnostic biomarkers; biochemical activities of natural product
Interests: cancer biology; cancer cells; cancer animal models; cancer research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The goal of cancer chemotherapy is to prevent or slow the growth of tumors using various biological or natural agents. Gene expression is regulated by epigenetic mechanisms throughout normal development, and their abnormal regulation may result in the development of human disorders such as cancer. In vitro and animal studies have shown that certain natural phytochemicals and dietary compounds may modulate signaling pathways involved in cell proliferation and apoptosis in transformed cells, strengthen the host immune system, and cause malignant cells to become more sensitive to cytotoxic agents. Epidemiological and preclinical data suggest that these compounds also have chemopreventive properties. Clinical research on a variety of dietary phytochemicals has produced mixed findings. Natural phytochemicals can significantly influence chromatin remodeling processes and proteins that control the mammalian epigenome. Most phytochemicals can be found in fruits, seeds, vegetables, and food supplements. These substances have potent anti-carcinogen properties. Numerous dietary substances demonstrate strong antitumor properties by reversing epigenetic changes linked to oncogene activation and tumor suppressor gene inactivation.
The Special Issue will focus on the actual knowledge about the role of dietary phytochemicals in the restoration of aberrant epigenetic alterations and modulation of signaling pathways in cancer cells.
Dr. Shashank Kumar
Prof. Dr. Sanjay Gupta
Guest Editors
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Keywords
- anticancer mode of action
- signaling pathway modulation
- preclinical models and dietary phytochemicals
- cancer hallmarks and dietary phytochemicals
- epigenetics/epigenomics and dietary phytochemicals
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