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Biosensors
Special Issues
Advanced Nanozyme for Biosensors
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Advanced Nanozyme for Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 2057

Special Issue Editor

Prof. Dr. Zhen Zhang

E-Mail Website
Guest Editor
School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China
Interests: monoclonal antibody and nano-antibody of new pollutants; rapid analysis; immunoassays; biosensors and electrochemistry; signal amplification; cell imaging based on DNA functional materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural enzymes with remarkable efficiency and good substrate specificity can catalyze biochemical reactions in various biological processes, but enzymes are hampered in biosensing applications due to their fragility under terrible conditions. Fortunately, the emergence of nanozymes with enzyme-like activity provides a possibility for exploring the candidates of natural enzymes. Nowadays, diverse nanozymes based on oxidase, peroxidase, superoxide dismutase, and laccase have been widely developed, which exhibit advantages such as a low cost, high stability, high activity, and ease of storage, showing enormous potential in biosensing applications. Therefore, the present Special Issue mainly focuses on the advanced nanozyme for biosensors, particularly in the areas of the fabrication of novel nanozymes, the strategy of enhancing the nanozyme activity, and their biosensing applications in environment monitoring, food safety, medical diagnosis, etc. We sincerely invite authors to submit manuscripts to further promote the basic study of nanozymes and expand their applications in various fields.

Prof. Dr. Zhen Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanozyme
  • biosensing
  • environment monitoring
  • food safety
  • medical diagnosis

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Published Papers (2 papers)

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Research

13 pages, 4866 KiB  
Article
Construction of Metal–Organic Framework as a Novel Platform for Ratiometric Determination of Cyanide
by Zongbao Sun, Zhiwei Wu, Yiran Zong, Chen Li, Wang Guo, Yiqing Guo and Xiaobo Zou
Biosensors 2024, 14(6), 276; https://doi.org/10.3390/bios14060276 - 27 May 2024
Viewed by 836
Abstract
Metal–organic frameworks (MOFs) are frequently utilized as sensing materials. Unfortunately, the low conductivity of MOFs hinder their further application in electrochemical determination. To overcome this limitation, a novel modification strategy for MOFs was proposed, establishing an electrochemical determination method for cyanides in Baijiu. [...] Read more.
Metal–organic frameworks (MOFs) are frequently utilized as sensing materials. Unfortunately, the low conductivity of MOFs hinder their further application in electrochemical determination. To overcome this limitation, a novel modification strategy for MOFs was proposed, establishing an electrochemical determination method for cyanides in Baijiu. Co and Ni were synergistically used as the metal active centers, with meso−Tetra(4−carboxyphenyl)porphine (TCPP) and Ferrocenecarboxylic acid (Fc−COOH) serving as the main ligands, synthesizing Ni/Co−MOF−TCPP−Fc through a hydrothermal method. The prepared MOF exhibited improved conductivity and stable ratio signals, enabling rapid and sensitive determination of cyanides. The screen−printed carbon electrodes (SPCE) were suitable for in situ and real−time determination of cyanide by electrochemical sensors due to their portability, low cost, and ease of mass production. A logarithmic linear response in the range of 0.196~44 ng/mL was demonstrated by this method, and the limit of detection (LOD) was 0.052 ng/mL. Compared with other methods, the sensor was constructed by a one−step synthesis method, which greatly simplifies the analysis process, and the determination time required was only 4 min. During natural cyanide determinations, recommended readouts match well with GC−MS with less than 5.9% relative error. Moreover, this electrochemical sensor presented a promising method for assessing the safety of cyanides in Baijiu. Full article
(This article belongs to the Special Issue Advanced Nanozyme for Biosensors)
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11 pages, 7827 KiB  
Communication
Morphology Control of Zr-Based Luminescent Metal-Organic Frameworks for Aflatoxin B1 Detection
by Fang Zhu, Qiuxue Chai, Dinghui Xiong, Nuanfei Zhu, Jialong Zhou, Ruoxi Wu and Zhen Zhang
Biosensors 2024, 14(6), 273; https://doi.org/10.3390/bios14060273 - 27 May 2024
Viewed by 891
Abstract
Metal–organic frameworks (MOFs) have gained significant prominence as sensing materials owing to their unique properties. However, understanding the correlation between the morphology, properties, and sensing performance in these MOF-based sensors remains a challenge, limiting their applications and potential for improvement. In this study, [...] Read more.
Metal–organic frameworks (MOFs) have gained significant prominence as sensing materials owing to their unique properties. However, understanding the correlation between the morphology, properties, and sensing performance in these MOF-based sensors remains a challenge, limiting their applications and potential for improvement. In this study, Zr-MOF was chosen as an ideal model to explore the impact of the MOF morphology on the sensing performance, given its remarkable stability and structural variability. Three luminescent MOFs (namely rod-like Zr-LMOF, prismoid-like Zr-LMOF, and ellipsoid-like Zr-LMOF) were synthesized by adjusting the quantities of the benzoic acid and the reaction time. More importantly, the sensing performance of these Zr-LMOFs in response to aflatoxin B1 (AFB1) was thoroughly examined. Notably, the ellipsoid-like Zr-LMOF exhibited significantly higher sensitivity compared to other Zr-LMOFs, attributed to its large specific surface area and pore volume. Additionally, an in-depth investigation into the detection mechanism of AFB1 by Zr-LMOFs was conducted. Building upon these insights, a ratiometric fluorescence sensor was developed by coordinating Eu3+ with ellipsoid-like Zr-LMOF, achieving a remarkably lower detection limit of 2.82 nM for AFB1. This study contributes to an improved comprehension of the relationship between the MOF morphology and the sensing characteristics while presenting an effective approach for AFB1 detection. Full article
(This article belongs to the Special Issue Advanced Nanozyme for Biosensors)
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