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Biosensors
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Nano Biosensor and Its Application for In Vivo/Vitro Diagnosis
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Nano Biosensor and Its Application for In Vivo/Vitro Diagnosis

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 9834

Special Issue Editor

Dr. Zhuangqiang Gao

E-Mail Website
Guest Editor
Marshall Laboratory of Biomedical Engineering, Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Health Science Centre, Shenzhen University, Shenzhen 518060, China
Interests: chemical and biological sensors; optical sensors; metal nanomaterials; catalysis; plasmonics; microfluidics; disease diagnosis; environmental monitoring
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nano-biosensors are a unique type of sensor that integrates the specific interactions of biomolecules and the superior properties of nanostructures into a sensor. The specific interactions of biomolecules, including nucleic acid hybridization, aptamer-target recognition, antibody–antigen binding, enzyme–substrate catalytic reactions, etc., ensure the high selectivity for detection and allow for the construction of various powerful signal generation/amplification principles for sensitive detection. On the other hand, the superior properties of nanostructures, such as electrical, magnetic, catalytic, optical, plasmonic, and photothermal activities, enable them to serve as versatile and efficient signal transducers and thus construct diverse signal generation/amplification strategies for highly effective detection as well. As a result, the synergistic combination of the interactions of biomolecules and the properties of nanostructures into an integrated sensor allows for detecting and sensing with higher analytical performance. Such emerging nano-biosensors show significant advantages over conventional analytical methods, which make them attractive for the in vivo/vitro analysis of biomarkers toward applications in in vivo/vitro diagnosis.

In view of this emerging field, it is my pleasure to invite you to contribute to this Special Issue by submitting an original research article or comprehensive review related to nano-biosensors and their applications in in vivo/vitro diagnosis. Topics in this Special Issue include, but are not limited to, the following:

  1. The design, synthesis/fabrication, and characterization of novel nanostructures (e.g., nanomaterials and nanodevices) with interesting properties that have promising potentials in biosensing;
  2. The design and development of innovative biosensors with high analytical performance using nanostructures;
  3. New sensing principles for nano-biosensors;
  4. Demonstration of new, promising diagnostic biomarkers using nano-biosensors;
  5. Emerging applications of nano-biosensors in in vivo/vitro diagnosis.

Dr. Zhuangqiang Gao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • nanostructures
  • nanomaterials
  • nanodevices
  • biosensors
  • biomarkers
  • in vivo/vitro diagnosis

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Published Papers (3 papers)

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Research

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11 pages, 2653 KiB  
Article
Intensity Interrogation-Based High-Sensitivity Surface Plasmon Resonance Imaging Biosensor for Apoptosis Detection in Cancer
by Xin Yuan, Zhenxiao Niu, Lang Liu, Youjun Zeng, Lin Ma, Zhaogang Nie, Zhen Tian, Dongyun Kai, Fangteng Zhang, Guanyu Liu, Siwei Li and Zhengqiang Yuan
Biosensors 2023, 13(10), 946; https://doi.org/10.3390/bios13100946 - 23 Oct 2023
Cited by 4 | Viewed by 2147
Abstract
Intensity interrogation-based surface plasmon resonance imaging (ISPRi) sensing has a simple schematic design and is the most widely used surface plasmon resonance technology at present. In this study, we report the successful development of a novel high-sensitivity ISPRi biosensor and its application for [...] Read more.
Intensity interrogation-based surface plasmon resonance imaging (ISPRi) sensing has a simple schematic design and is the most widely used surface plasmon resonance technology at present. In this study, we report the successful development of a novel high-sensitivity ISPRi biosensor and its application for apoptosis detection in cancer cells. By optimizing the excitation wavelength and excitation angle, we achieved a refractive index resolution (RIR) of 5.20 × 10−6 RIU. Importantly, the biosensor has been tested and validated for high-throughput and label-free detection of activated caspase-3 with its specific inhibitor Z-DEVD-FMK in apoptotic cells. Therefore, this study describes a novel molecular imaging system to monitor apoptosis in cancers for disease diagnosis and/or evaluation of therapeutic efficacy of anti-cancer drugs. Full article
(This article belongs to the Special Issue Nano Biosensor and Its Application for In Vivo/Vitro Diagnosis)
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14 pages, 3124 KiB  
Article
Prostate-Specific Antigen Monitoring Using Nano Zinc(II) Metal–Organic Framework-Based Optical Biosensor
by Said M. El-Sheikh, Sheta M. Sheta, Salem R. Salem, Mohkles M. Abd-Elzaher, Amal S. Basaleh and Ammar A. Labib
Biosensors 2022, 12(11), 931; https://doi.org/10.3390/bios12110931 - 27 Oct 2022
Cited by 6 | Viewed by 2376
Abstract
Background: The prostate-specific antigen (PSA) is an important cancer biomarker that is commonly utilized in the diagnosis of prostate cancer. The development of a PSA determination technique that is rapid, simple, and inexpensive, in addition to highly accurate, sensitive, and selective, remains a [...] Read more.
Background: The prostate-specific antigen (PSA) is an important cancer biomarker that is commonly utilized in the diagnosis of prostate cancer. The development of a PSA determination technique that is rapid, simple, and inexpensive, in addition to highly accurate, sensitive, and selective, remains a formidable obstacle. Methods: In this study, we developed a practical biosensor based on Zn(II) metal–organic framework nanoparticles (Zn-MOFs-NPs). Many spectroscopic and microanalytical tools are used to determine the structure, morphology, and physicochemical properties of the prepared MOF. Results: According to the results, Zn-MOFs-NPs are sensitive to PSA, selective to an extremely greater extent, and stable in terms of chemical composition. Furthermore, the Zn-MOFs-NPs did not exhibit any interferences from other common analytes that might cause interference. The detection limit for PSA was calculated and was 0.145 fg/mL throughout a wide linear concentration range (0.1 fg/mL–20 pg/mL). Conclusions: Zn-MOFs-NPs were successfully used as a growing biosensor for the monitoring and measurement of PSA in biological real samples. Full article
(This article belongs to the Special Issue Nano Biosensor and Its Application for In Vivo/Vitro Diagnosis)
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Review

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30 pages, 4958 KiB  
Review
Recent Advances in Aptamer-Based Biosensors for Bacterial Detection
by Vincent Léguillier, Brahim Heddi and Jasmina Vidic
Biosensors 2024, 14(5), 210; https://doi.org/10.3390/bios14050210 - 23 Apr 2024
Cited by 4 | Viewed by 4643
Abstract
The rapid and sensitive detection of pathogenic bacteria is becoming increasingly important for the timely prevention of contamination and the treatment of infections. Biosensors based on nucleic acid aptamers, integrated with optical, electrochemical, and mass-sensitive analytical techniques, have garnered intense interest because of [...] Read more.
The rapid and sensitive detection of pathogenic bacteria is becoming increasingly important for the timely prevention of contamination and the treatment of infections. Biosensors based on nucleic acid aptamers, integrated with optical, electrochemical, and mass-sensitive analytical techniques, have garnered intense interest because of their versatility, cost-efficiency, and ability to exhibit high affinity and specificity in binding bacterial biomarkers, toxins, and whole cells. This review highlights the development of aptamers, their structural characterization, and the chemical modifications enabling optimized recognition properties and enhanced stability in complex biological matrices. Furthermore, recent examples of aptasensors for the detection of bacterial cells, biomarkers, and toxins are discussed. Finally, we explore the barriers to and discuss perspectives on the application of aptamer-based bacterial detection. Full article
(This article belongs to the Special Issue Nano Biosensor and Its Application for In Vivo/Vitro Diagnosis)
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