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Biosensors
Special Issues
Emerging Biosensing Technologies for Healthcare Applications
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Emerging Biosensing Technologies for Healthcare Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (18 October 2023) | Viewed by 16408

Special Issue Editors

Prof. Dr. Suna Timur

E-Mail Website
Guest Editor
Biochemistry Department, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey
Interests: biosensors; point of care diagnostics; immunosensors; lateral flow assays
Dr. Tutku Beduk

E-Mail Website
Guest Editor
Silicon Austria Labs GmbH: Sensor Systems, 9524 Villach, Austria
Interests: biosensors; flexible electronics; molecularly imprinting; laser-scribed graphene; point of care diagnostics

Special Issue Information

Dear Colleagues,

Biosensors are powerful diagnostic tools that can serve as an alternative to traditional detection methods. Various studies have been conducted to provide efficient diagnosis for various diseases, such as cardiovascular diseases, bacterial or viral infections, inflammatory diseases, etc. With emerging point-of-care (PoC) diagnostic systems, patients have the possibility to test themselves and take necessary actions. Recent innovative developments of diagnostic devices have allowed enhanced analytical performance, miniaturized sensors, multiplex analysis, and readout signal enhancement. Whether electrochemical or optical, new sensing technologies play an important role in the healthcare field as portable, wearable, or implantable devices. In addition, the use of smartphones for operation and readout offers tremendous possibilities for on-site detection analysis due to their portability, high accessibility, fast sample processing, and robust imaging capabilities. Straightforward digital analysis and convenient user interfaces support networked healthcare systems and individualized health monitoring.

Prof. Dr. Suna Timur
Dr. Tutku Beduk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • point-of-care diagnostics
  • personalized medicine
  • electrochemical sensor
  • clinical diagnosis
  • biomarkers
  • biosensors
  • optical sensor

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Published Papers (5 papers)

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Research

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16 pages, 3496 KiB  
Article
Evaluating the Potential of an Oral-Based Bioguard to Estimate Heart Rate Using Photoplethysmography
by Leonardo de Almeida e Bueno, Victoria C. Walls and Jeroen H. M. Bergmann
Biosensors 2023, 13(5), 533; https://doi.org/10.3390/bios13050533 - 10 May 2023
Cited by 1 | Viewed by 2007
Abstract
The reliable monitoring of heart rate during intense exercise is imperative to effectively manage training loads while providing insights from a healthcare perspective. However, current technologies perform poorly in contact sports settings. This study aims to evaluate the best approach for heart rate [...] Read more.
The reliable monitoring of heart rate during intense exercise is imperative to effectively manage training loads while providing insights from a healthcare perspective. However, current technologies perform poorly in contact sports settings. This study aims to evaluate the best approach for heart rate tracking using photoplethysmography sensors embedded into an instrumented mouthguard (iMG). Seven adults wore iMGs and a reference heart rate monitor. Several sensor placements, light sources and signal intensities were explored for the iMG. A novel metric related to the positioning of the sensor in the gum was introduced. The error between the iMG heart rate and the reference data was assessed to obtain insights into the effect of specific iMG configurations on measurement errors. Signal intensity was found to be the most important variable for error prediction, followed by the sensor light source, sensor placement and positioning. A generalized linear model combining an infrared light source, at an intensity of 5.08 mA, and a frontal placement high in the gum area resulted in a heart rate minimum error of 16.33%. This research shows promising preliminary results for the use of oral-based heart rate monitoring, but highlights the need for the careful consideration of sensor configurations within these systems. Full article
(This article belongs to the Special Issue Emerging Biosensing Technologies for Healthcare Applications)
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14 pages, 3743 KiB  
Article
Electro-Nano Diagnostic Platform Based on Antibody–Antigen Interaction: An Electrochemical Immunosensor for Influenza A Virus Detection
by Yudum Tepeli Büyüksünetçi and Ülkü Anık
Biosensors 2023, 13(2), 176; https://doi.org/10.3390/bios13020176 - 23 Jan 2023
Cited by 7 | Viewed by 2658
Abstract
H1N1 is a kind of influenza A virus that causes serious health issues throughout the world. Its symptoms are more serious than seasonal flu and can sometimes be lethal. For this reason, rapid, accurate, and effective diagnostic tests are needed. In this study, [...] Read more.
H1N1 is a kind of influenza A virus that causes serious health issues throughout the world. Its symptoms are more serious than seasonal flu and can sometimes be lethal. For this reason, rapid, accurate, and effective diagnostic tests are needed. In this study, an electrochemical immunosensor for the sensitive, selective, and practical detection of the H1N1 virus was developed. The sensor platform included multi-walled carbon nanotube gold-platinum (MWCNT-Au-Pt) hybrid nanomaterial and anti-hemagglutinin (anti-H1) monoclonal antibody. For the construction of this biosensor, a gold screen-printed electrode (AuSPE) was used as a transducer. Firstly, AuSPE was modified with MWCNT-Au-Pt hybrid nanomaterial via drop casting. Anti-H1 antibody was immobilized onto the electrode surface after the modification process with cysteamine was applied. Then, the effect of the interaction time with cysteamine for surface modification was investigated. Following that, the experimental parameters, such as the amount of hybrid nanomaterial and the concentration of anti-H1 were optimized. Under the optimized conditions, the analytical characteristics of the developed electrochemical immunosensor were investigated for the H1N1 virus by using electrochemical impedance spectroscopy. As a result, a linear range was obtained between 2.5–25.0 µg/mL with a limit of the detection value of 3.54 µg/mL. The relative standard deviation value for 20 µg/mL of the H1N1 virus was also calculated and found as 0.45% (n = 3). In order to determine the selectivity of the developed anti-H1-based electrochemical influenza A immunosensor, the response of this system towards the H3N2 virus was investigated. The matrix effect was also investigated by using synthetic saliva supplemented with H1N1 virus. Full article
(This article belongs to the Special Issue Emerging Biosensing Technologies for Healthcare Applications)
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Review

Jump to: Research

16 pages, 2491 KiB  
Review
Design of Polymeric Surfaces as Platforms for Streamlined Cancer Diagnostics in Liquid Biopsies
by Faezeh Ghorbanizamani, Hichem Moulahoum, Emine Guler Celik, Figen Zihnioglu, Tutku Beduk, Tuncay Goksel, Kutsal Turhan and Suna Timur
Biosensors 2023, 13(3), 400; https://doi.org/10.3390/bios13030400 - 18 Mar 2023
Cited by 3 | Viewed by 2282
Abstract
Minimally invasive approaches for cancer diagnosis are an integral step in the quest to improve cancer survival. Liquid biopsies such as blood samples are matrices explored to extract valuable information about the tumor and its state through various indicators, such as proteins, peptides, [...] Read more.
Minimally invasive approaches for cancer diagnosis are an integral step in the quest to improve cancer survival. Liquid biopsies such as blood samples are matrices explored to extract valuable information about the tumor and its state through various indicators, such as proteins, peptides, tumor DNA, or circulating tumor cells. Although these markers are scarce, making their isolation and detection in complex matrices challenging, the development in polymer chemistry producing interesting structures, including molecularly imprinted polymers, branched polymers, nanopolymer composites, and hybrids, allowed the development of enhanced platforms with impressive performance for liquid biopsies analysis. This review describes the latest advances and developments in polymer synthesis and their application for minimally invasive cancer diagnosis. The polymer structures improve the operational performances of biosensors through various processes, such as increased affinity for enhanced sensitivity, improved binding, and avoidance of non-specific interactions for enhanced specificity. Furthermore, polymer-based materials can be a tremendous help in signal amplification of usually low-concentrated targets in the sample. The pros and cons of these materials, how the synthesis process affects their performance, and the device applications for liquid biopsies diagnosis will be critically reviewed to show the essentiality of this technology in oncology and clinical biomedicine. Full article
(This article belongs to the Special Issue Emerging Biosensing Technologies for Healthcare Applications)
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17 pages, 2904 KiB  
Review
Approaches and Challenges for Biosensors for Acute and Chronic Heart Failure
by Sariye Irem Kaya, Ahmet Cetinkaya, Goksu Ozcelikay, Seyda Nur Samanci and Sibel A. Ozkan
Biosensors 2023, 13(2), 282; https://doi.org/10.3390/bios13020282 - 16 Feb 2023
Cited by 7 | Viewed by 2915
Abstract
Heart failure (HF) is a cardiovascular disease defined by several symptoms that occur when the heart cannot supply the blood needed by the tissues. HF, which affects approximately 64 million people worldwide and whose incidence and prevalence are increasing, has an important place [...] Read more.
Heart failure (HF) is a cardiovascular disease defined by several symptoms that occur when the heart cannot supply the blood needed by the tissues. HF, which affects approximately 64 million people worldwide and whose incidence and prevalence are increasing, has an important place in terms of public health and healthcare costs. Therefore, developing and enhancing diagnostic and prognostic sensors is an urgent need. Using various biomarkers for this purpose is a significant breakthrough. It is possible to classify the biomarkers used in HF: associated with myocardial and vascular stretch (B-type natriuretic peptide (BNP), N-terminal proBNP and troponin), related to neurohormonal pathways (aldosterone and plasma renin activity), and associated with myocardial fibrosis and hypertrophy (soluble suppression of tumorigenicity 2 and galactin 3). There is an increasing demand for the design of fast, portable, and low-cost biosensing devices for the biomarkers related to HF. Biosensors play a significant role in early diagnosis as an alternative to time-consuming and expensive laboratory analysis. In this review, the most influential and novel biosensor applications for acute and chronic HF will be discussed in detail. These studies will be evaluated in terms of advantages, disadvantages, sensitivity, applicability, user-friendliness, etc. Full article
(This article belongs to the Special Issue Emerging Biosensing Technologies for Healthcare Applications)
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32 pages, 4461 KiB  
Review
Engineered Biosensors for Diagnosing Multidrug Resistance in Microbial and Malignant Cells
by Niharika G. Jha, Daphika S. Dkhar, Sumit K. Singh, Shweta J. Malode, Nagaraj P. Shetti and Pranjal Chandra
Biosensors 2023, 13(2), 235; https://doi.org/10.3390/bios13020235 - 7 Feb 2023
Cited by 7 | Viewed by 3431
Abstract
To curtail pathogens or tumors, antimicrobial or antineoplastic drugs have been developed. These drugs target microbial/cancer growth and survival, thereby improving the host’s health. In attempts to evade the detrimental effects of such drugs, these cells have evolved several mechanisms over time. Some [...] Read more.
To curtail pathogens or tumors, antimicrobial or antineoplastic drugs have been developed. These drugs target microbial/cancer growth and survival, thereby improving the host’s health. In attempts to evade the detrimental effects of such drugs, these cells have evolved several mechanisms over time. Some variants of the cells have developed resistances against multiple drugs or antimicrobial agents. Such microorganisms or cancer cells are said to exhibit multidrug resistance (MDR). The drug resistance status of a cell can be determined by analyzing several genotypic and phenotypic changes, which are brought about by significant physiological and biochemical alterations. Owing to their resilient nature, treatment and management of MDR cases in clinics is arduous and requires a meticulous approach. Currently, techniques such as plating and culturing, biopsy, gene sequencing, and magnetic resonance imaging are prevalent in clinical practices for determining drug resistance status. However, the major drawbacks of using these methods lie in their time-consuming nature and the problem of translating them into point-of-care or mass-detection tools. To overcome the shortcomings of conventional techniques, biosensors with a low detection limit have been engineered to provide quick and reliable results conveniently. These devices are highly versatile in terms of analyte range and quantities that can be detected to report drug resistance in a given sample. A brief introduction to MDR, along with a detailed insight into recent biosensor design trends and use for identifying multidrug-resistant microorganisms and tumors, is presented in this review. Full article
(This article belongs to the Special Issue Emerging Biosensing Technologies for Healthcare Applications)
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