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Biosensors
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Noble Metal Nanoparticle-Based Nanoplatforms for Biosensors
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Noble Metal Nanoparticle-Based Nanoplatforms for Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 6818

Special Issue Editors

Dr. Hongya Geng

E-Mail Website
Guest Editor
Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
Interests: hydrogels; tissue engineering; theranostics
Special Issues, Collections and Topics in MDPI journals
Dr. Haipeng Li

E-Mail Website
Guest Editor
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17165 Stockholm, Sweden
Interests: Surface enhanced Raman scattering/spectroscopy (SERS), nano-sensor technology, and their applications in food safety diagnostics and biosensing.

Special Issue Information

Dear Colleagues,

Noble metal nanoparticles, particularly gold, silver, and platinum nanoparticles, are widely employed in diagnosis due to their unique optical and catalytic properties. The collective oscillation of free electrons under light irradiation results in tunable light–matter interactions, surface-enhanced Raman scattering, and photothermal conversions for multiplexed detection and photoacoustic imaging. The enzyme-like catalytic properties, on the other hand, are widely highlighted to achieve significant signal amplification for developing high-performance in vitro diagnostic devices. The customizability of noble metal nanoparticles via mechanisms including aggregation/dispersion and etching endows them with the capability to quantitatively detect analytes from physiological fluids for point-of-care diagnosis of various diseases. Furthermore, size-, shape-, and surface-dependent properties are critical for improving their performance in high-profile disease detection. The field of noble metal nanoparticles is largely dependent on methodologies of fabrication and engineering to greatly promote sensing performance.

This Special Issue entitled “Noble Metal Nanoparticle-Based Nanoplatforms for Biosensors” is devoted to recent advancements in noble metal nanoparticles, which address the challenge of diagnostic agents. We invite up-to-date manuscripts in engineering and fabrication of noble metal nanoparticles for biomedical applications. This issue will showcase recent developments in chemistry to prepare and modify different noble metal nanoparticles and highlight emerging biosensors.

Dr. Hongya Geng
Dr. Haipeng Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • noble metal nanoparticles
  • imaging
  • diagnosis
  • sensing
  • photothermal
  • catalysis
  • point-of-care diagnosis
  • biosensors

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Published Papers (4 papers)

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Research

16 pages, 3742 KiB  
Article
Comparison of Survivin Determination by Surface-Enhanced Fluorescence and Raman Spectroscopy on Nanostructured Silver Substrates
by Georgia Geka, Anastasia Kanioura, Ioannis Kochylas, Vlassis Likodimos, Spiros Gardelis, Anastasios Dimitriou, Nikolaos Papanikolaou, Anastasios Economou, Sotirios Kakabakos and Panagiota Petrou
Biosensors 2024, 14(10), 479; https://doi.org/10.3390/bios14100479 - 6 Oct 2024
Viewed by 937
Abstract
Survivin belongs to a family of proteins that promote cellular proliferation and inhibit cellular apoptosis. Its overexpression in various cancer types has led to its recognition as an important marker for cancer diagnosis and treatment. In this work, we compare two approaches for [...] Read more.
Survivin belongs to a family of proteins that promote cellular proliferation and inhibit cellular apoptosis. Its overexpression in various cancer types has led to its recognition as an important marker for cancer diagnosis and treatment. In this work, we compare two approaches for the immunochemical detection of survivin through surface-enhanced fluorescence or Raman spectroscopy using surfaces with nanowires decorated with silver nanoparticles in the form of dendrites or aggregates as immunoassays substrates. In both substrates, a two-step non-competitive immunoassay was developed using a pair of specific monoclonal antibodies, one for detection and the other for capture. The detection antibody was biotinylated and combined with streptavidin labeled with rhodamine for the detection of surface-enhanced fluorescence, while, for the detection via Raman spectroscopy, streptavidin labeled with peroxidase was used and the signal was obtained after the application of 3,3′,5,5′-tetramethylbenzidine (TMB) precipitating substrate. It was found that the substrate with the silver dendrites provided higher fluorescence signal intensity compared to the substrate with the silver aggregates, while the opposite was observed for the Raman signal. Thus, the best substrate was used for each detection method. A detection limit of 12.5 pg/mL was achieved with both detection approaches along with a linear dynamic range up to 500 pg/mL, enabling survivin determination in human serum samples from both healthy and ovarian cancer patients for cancer diagnosis and monitoring purposes. Full article
(This article belongs to the Special Issue Noble Metal Nanoparticle-Based Nanoplatforms for Biosensors)
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12 pages, 3346 KiB  
Article
Development of a “Signal-On” Fluorescent Aptasensor for Highly Selective and Sensitive Detection of ZEN in Cereal Products Using Nitrogen-Doped Carbon Dots Based on the Inner Filter Effect
by Qi Sun, Yuting Zhou, Miaomiao Ma, Fuyan Zhang, Shuang Li, Zhuoer Chen, Yu Fang, Tao Le and Fuguo Xing
Biosensors 2024, 14(7), 347; https://doi.org/10.3390/bios14070347 - 17 Jul 2024
Viewed by 1104
Abstract
This study aimed to develop a novel fluorescent aptasensor for the quantitative detection of zearalenone (ZEN), addressing the limitations of conventional detection techniques in terms of speed, sensitivity, and ease of use. Nitrogen-doped carbon dots (N-CDs) were synthesized via the hydrothermal method, resulting [...] Read more.
This study aimed to develop a novel fluorescent aptasensor for the quantitative detection of zearalenone (ZEN), addressing the limitations of conventional detection techniques in terms of speed, sensitivity, and ease of use. Nitrogen-doped carbon dots (N-CDs) were synthesized via the hydrothermal method, resulting in spherical particles with a diameter of 3.25 nm. These N-CDs demonstrated high water solubility and emitted a bright blue light at 440 nm when excited at 355 nm. The fluorescence of N-CDs was quenched by dispersed gold nanoparticles (AuNPs) through the inner filter effect, while aggregated AuNPs induced by NaCl did not affect the fluorescence of N-CDs. The aptamer could protect AuNPs from NaCl-induced aggregation, but the presence of ZEN weakened this protective effect. Based on this principle, optimal conditions for ZEN detection included 57 mM NaCl, 12.5 nM aptamer concentration, incubation of AuNPs with NaCl for 15 min in Tris-EDTA(TE) buffer, and incubation of aptamer with ZEN and NaCl for 30 min. Under these optimized conditions, the “signal-on” fluorescent aptasensor for ZEN detection showed a linear range of 0.25 to 200 ng/mL with a low detection limit of 0.0875 ng/mL. Furthermore, the developed aptasensor exhibited excellent specificity and could rapidly detect ZEN in corn flour samples or corn oil, achieving satisfactory recovery rates ranging from 84.7% to 108.6%. Therefore, this study presents an economical, convenient, sensitive, and rapid method for accurately quantifying ZEN in cereal products. Full article
(This article belongs to the Special Issue Noble Metal Nanoparticle-Based Nanoplatforms for Biosensors)
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12 pages, 3035 KiB  
Article
Weak Value Amplification-Based Biochip for Highly Sensitive Detection and Identification of Breast Cancer Exosomes
by Jingru Zhao, Xiaotian Guan, Sihao Zhang, Zhou Sha and Shuqing Sun
Biosensors 2024, 14(4), 198; https://doi.org/10.3390/bios14040198 - 17 Apr 2024
Viewed by 1703
Abstract
Exosomes constitute an emerging biomarker for cancer diagnosis because they carry multiple proteins that reflect the origins of the parent cell. The highly sensitive detection of exosomes is a crucial prerequisite for the diagnosis of cancer. In this study, we report an exosome [...] Read more.
Exosomes constitute an emerging biomarker for cancer diagnosis because they carry multiple proteins that reflect the origins of the parent cell. The highly sensitive detection of exosomes is a crucial prerequisite for the diagnosis of cancer. In this study, we report an exosome detection system based on quantum weak value amplification (WVA). The WVA detection system consists of a reflection detection light path and a Zr-ionized biochip. Zr-ionized biochips effectively capture exosomes through the specific interaction between zirconium dioxide and the phosphate groups on the lipid bilayer of exosomes. Aptamer-modified gold nanoparticles (Au NPs) are then used to specifically recognize proteins on exosomes to enhance the detection signal. The sensitivity and resolution of the detection system are 2944.07 nm/RIU and 1.22 × 10−5 RIU, respectively. The concentration of exosomes can be directly quantified by the WVA system, ranging from 105–107 particles/mL with the detection limit of 3 × 104 particles/mL. The use of Au NPs-EpCAM for the specific enhancement of breast cancer MDA-MB-231 exosomes is demonstrated. The results indicate that the WVA detection system can be a promising candidate for the detection of exosomes as tumor markers. Full article
(This article belongs to the Special Issue Noble Metal Nanoparticle-Based Nanoplatforms for Biosensors)
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13 pages, 3445 KiB  
Article
Simple, Visual, Point-of-Care SARS-CoV-2 Detection Incorporating Recombinase Polymerase Amplification and Target DNA–Protein Crosslinking Enhanced Chemiluminescence
by Hui Chen, Zhiyuan Zhuang, Naihan Xu, Ying Feng, Kaixin Fang, Chunyan Tan and Ying Tan
Biosensors 2024, 14(3), 135; https://doi.org/10.3390/bios14030135 - 6 Mar 2024
Cited by 2 | Viewed by 2199
Abstract
The ongoing COVID-19 pandemic, driven by persistent SARS-CoV-2 transmission, threatens human health worldwide, underscoring the urgent need for an efficient, low-cost, rapid SARS-CoV-2 detection method. Herein, we developed a point-of-care SARS-CoV-2 detection method incorporating recombinase polymerase amplification (RPA) and DNA–protein crosslinking chemiluminescence (DPCL) [...] Read more.
The ongoing COVID-19 pandemic, driven by persistent SARS-CoV-2 transmission, threatens human health worldwide, underscoring the urgent need for an efficient, low-cost, rapid SARS-CoV-2 detection method. Herein, we developed a point-of-care SARS-CoV-2 detection method incorporating recombinase polymerase amplification (RPA) and DNA–protein crosslinking chemiluminescence (DPCL) (RPADPCL). RPADPCL involves the crosslinking of biotinylated double-stranded RPA DNA products with horseradish peroxidase (HRP)-labeled streptavidin (SA-HRP). Modified products are captured using SA-labeled magnetic beads, and then analyzed using a chemiluminescence detector and smartphone after the addition of a chemiluminescent substrate. Under optimal conditions, the RPADPCL limit of detection (LOD) was observed to be 6 copies (within the linear detection range of 1–300 copies) for a plasmid containing the SARS-CoV-2 N gene and 15 copies (within the linear range of 10–500 copies) for in vitro transcribed (IVT) SARS-CoV-2 RNA. The proposed method is convenient, specific, visually intuitive, easy to use, and does not require external excitation. The effective RPADPCL detection of SARS-CoV-2 in complex matrix systems was verified by testing simulated clinical samples containing 10% human saliva or a virus transfer medium (VTM) spiked with a plasmid containing a SARS-CoV-2 N gene sequence or SARS-CoV-2 IVT RNA. Consequently, this method has great potential for detecting targets in clinical samples. Full article
(This article belongs to the Special Issue Noble Metal Nanoparticle-Based Nanoplatforms for Biosensors)
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